The association of smoothness index of central blood pressure with ambulatory carotid femoral pulse wave velocity after 20-week treatment with losartan in combination with amlodipine versus hydrochlorothiazide

Jinho Shin, Hae Young Lee, Wook Jin Chung, Ho Joong Youn, Eun Joo Cho, Ki Chul Sung, Shung Chull Chae, Byung Su Yoo, Chang Gyu Park, Soon Jun Hong, Taek Jong Hong, Dong Ju Choi, Jong Won Ha, Young Jo Kim, Young Keun Ahn, Myeong Chan Cho, Soon Kil Kim, Sungha Park, Il Suk Sohn, Chong Jin Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVES: The aim of this study was to identify associations between the smoothness index of central SBP (CSBP) and changes of ambulatory carotid femoral pulse wave velocity in response to 20-week treatments with losartan and amlodipine vs. losartan and hydrochlorthiazide combinations. METHODS: For 142 (losartan and hydrochlorthiazide: 72, losartan and hydrochlorthiazide: 70) patients examined with ambulatory central blood pressure (BP) monitoring device, we calculated smoothness indices and trough-to-peak ratios of brachial SBP, CSBP, ambulatory pulse pressure amplification (APPA), ambulatory augmentation index at heart rate 75 beats per minute (AAIx75) and ambulatory carotid femoral pulse wave velocity (AcfPWV). RESULTS: Mean age was 58.9 ± 12.3 years, and women accounted for 25.9%. Changes in office SBP/DBP were not different between groups (losartan and hydrochlorthiazide: -15.2 ± 15.0/-7.8 ± 8.0 vs. losartan and amlodipine: -14.9 ± 13.7/-9.2 ± 7.5 mmHg). Reduction of 24-h CSBP was not significantly different (losartan and hydrochlorthiazide: 6.4 ± 1.1 vs. losartan and amlodipine: 9.2 ± 1.1 mmHg, P = 0.074). Reduction in nocturnal AcfPWV was greater in the losartan and amlodipine group (losartan and hydrochlorthiazide: 0.09 ± 0.05 vs. losartan and amlodipine: 0.26 ± 0.05 m/s, P = 0.0216). Intraindividual SIs for CSBP were higher in the losartan and amlodipine group (0.40 ± 0.57 vs. 0.65 ± 0.74, P = 0.022). In multivariable regression analysis, smoothness index of CSBP was independently associated with the losartan and amlodipine group. In model additionally considering the changes in arterial stiffness, decrease in AcfPWV instead of the treatment group was independently associated with smoothness indices. In mediation analysis, smoothness index was fully mediated by reduction in night-time AcfPWV. CONCLUSION: Losartan and amlodipine combination was superior to the losartan and hydrochlorthiazide combination in terms of achieving higher smoothness index for CSBP after 20-week treatments. The effect of losartan and amlodipine on smoothness index was fully mediated by reduction of night-time AcfPWV.

Original languageEnglish
Pages (from-to)2490-2497
Number of pages8
JournalJournal of hypertension
Volume37
Issue number12
DOIs
Publication statusPublished - 2019 Dec 1

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Amlodipine
Pulse Wave Analysis
Hydrochlorothiazide
Losartan
Thigh
Blood Pressure
Therapeutics
Ambulatory Blood Pressure Monitoring
Vascular Stiffness

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Shin, Jinho ; Lee, Hae Young ; Chung, Wook Jin ; Youn, Ho Joong ; Cho, Eun Joo ; Sung, Ki Chul ; Chae, Shung Chull ; Yoo, Byung Su ; Park, Chang Gyu ; Hong, Soon Jun ; Hong, Taek Jong ; Choi, Dong Ju ; Ha, Jong Won ; Kim, Young Jo ; Ahn, Young Keun ; Cho, Myeong Chan ; Kim, Soon Kil ; Park, Sungha ; Sohn, Il Suk ; Kim, Chong Jin. / The association of smoothness index of central blood pressure with ambulatory carotid femoral pulse wave velocity after 20-week treatment with losartan in combination with amlodipine versus hydrochlorothiazide. In: Journal of hypertension. 2019 ; Vol. 37, No. 12. pp. 2490-2497.
@article{c1a64a59f29041c8b1dc50abe5983eb9,
title = "The association of smoothness index of central blood pressure with ambulatory carotid femoral pulse wave velocity after 20-week treatment with losartan in combination with amlodipine versus hydrochlorothiazide",
abstract = "OBJECTIVES: The aim of this study was to identify associations between the smoothness index of central SBP (CSBP) and changes of ambulatory carotid femoral pulse wave velocity in response to 20-week treatments with losartan and amlodipine vs. losartan and hydrochlorthiazide combinations. METHODS: For 142 (losartan and hydrochlorthiazide: 72, losartan and hydrochlorthiazide: 70) patients examined with ambulatory central blood pressure (BP) monitoring device, we calculated smoothness indices and trough-to-peak ratios of brachial SBP, CSBP, ambulatory pulse pressure amplification (APPA), ambulatory augmentation index at heart rate 75 beats per minute (AAIx75) and ambulatory carotid femoral pulse wave velocity (AcfPWV). RESULTS: Mean age was 58.9 ± 12.3 years, and women accounted for 25.9{\%}. Changes in office SBP/DBP were not different between groups (losartan and hydrochlorthiazide: -15.2 ± 15.0/-7.8 ± 8.0 vs. losartan and amlodipine: -14.9 ± 13.7/-9.2 ± 7.5 mmHg). Reduction of 24-h CSBP was not significantly different (losartan and hydrochlorthiazide: 6.4 ± 1.1 vs. losartan and amlodipine: 9.2 ± 1.1 mmHg, P = 0.074). Reduction in nocturnal AcfPWV was greater in the losartan and amlodipine group (losartan and hydrochlorthiazide: 0.09 ± 0.05 vs. losartan and amlodipine: 0.26 ± 0.05 m/s, P = 0.0216). Intraindividual SIs for CSBP were higher in the losartan and amlodipine group (0.40 ± 0.57 vs. 0.65 ± 0.74, P = 0.022). In multivariable regression analysis, smoothness index of CSBP was independently associated with the losartan and amlodipine group. In model additionally considering the changes in arterial stiffness, decrease in AcfPWV instead of the treatment group was independently associated with smoothness indices. In mediation analysis, smoothness index was fully mediated by reduction in night-time AcfPWV. CONCLUSION: Losartan and amlodipine combination was superior to the losartan and hydrochlorthiazide combination in terms of achieving higher smoothness index for CSBP after 20-week treatments. The effect of losartan and amlodipine on smoothness index was fully mediated by reduction of night-time AcfPWV.",
author = "Jinho Shin and Lee, {Hae Young} and Chung, {Wook Jin} and Youn, {Ho Joong} and Cho, {Eun Joo} and Sung, {Ki Chul} and Chae, {Shung Chull} and Yoo, {Byung Su} and Park, {Chang Gyu} and Hong, {Soon Jun} and Hong, {Taek Jong} and Choi, {Dong Ju} and Ha, {Jong Won} and Kim, {Young Jo} and Ahn, {Young Keun} and Cho, {Myeong Chan} and Kim, {Soon Kil} and Sungha Park and Sohn, {Il Suk} and Kim, {Chong Jin}",
year = "2019",
month = "12",
day = "1",
doi = "10.1097/HJH.0000000000002202",
language = "English",
volume = "37",
pages = "2490--2497",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

Shin, J, Lee, HY, Chung, WJ, Youn, HJ, Cho, EJ, Sung, KC, Chae, SC, Yoo, BS, Park, CG, Hong, SJ, Hong, TJ, Choi, DJ, Ha, JW, Kim, YJ, Ahn, YK, Cho, MC, Kim, SK, Park, S, Sohn, IS & Kim, CJ 2019, 'The association of smoothness index of central blood pressure with ambulatory carotid femoral pulse wave velocity after 20-week treatment with losartan in combination with amlodipine versus hydrochlorothiazide', Journal of hypertension, vol. 37, no. 12, pp. 2490-2497. https://doi.org/10.1097/HJH.0000000000002202

The association of smoothness index of central blood pressure with ambulatory carotid femoral pulse wave velocity after 20-week treatment with losartan in combination with amlodipine versus hydrochlorothiazide. / Shin, Jinho; Lee, Hae Young; Chung, Wook Jin; Youn, Ho Joong; Cho, Eun Joo; Sung, Ki Chul; Chae, Shung Chull; Yoo, Byung Su; Park, Chang Gyu; Hong, Soon Jun; Hong, Taek Jong; Choi, Dong Ju; Ha, Jong Won; Kim, Young Jo; Ahn, Young Keun; Cho, Myeong Chan; Kim, Soon Kil; Park, Sungha; Sohn, Il Suk; Kim, Chong Jin.

In: Journal of hypertension, Vol. 37, No. 12, 01.12.2019, p. 2490-2497.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association of smoothness index of central blood pressure with ambulatory carotid femoral pulse wave velocity after 20-week treatment with losartan in combination with amlodipine versus hydrochlorothiazide

AU - Shin, Jinho

AU - Lee, Hae Young

AU - Chung, Wook Jin

AU - Youn, Ho Joong

AU - Cho, Eun Joo

AU - Sung, Ki Chul

AU - Chae, Shung Chull

AU - Yoo, Byung Su

AU - Park, Chang Gyu

AU - Hong, Soon Jun

AU - Hong, Taek Jong

AU - Choi, Dong Ju

AU - Ha, Jong Won

AU - Kim, Young Jo

AU - Ahn, Young Keun

AU - Cho, Myeong Chan

AU - Kim, Soon Kil

AU - Park, Sungha

AU - Sohn, Il Suk

AU - Kim, Chong Jin

PY - 2019/12/1

Y1 - 2019/12/1

N2 - OBJECTIVES: The aim of this study was to identify associations between the smoothness index of central SBP (CSBP) and changes of ambulatory carotid femoral pulse wave velocity in response to 20-week treatments with losartan and amlodipine vs. losartan and hydrochlorthiazide combinations. METHODS: For 142 (losartan and hydrochlorthiazide: 72, losartan and hydrochlorthiazide: 70) patients examined with ambulatory central blood pressure (BP) monitoring device, we calculated smoothness indices and trough-to-peak ratios of brachial SBP, CSBP, ambulatory pulse pressure amplification (APPA), ambulatory augmentation index at heart rate 75 beats per minute (AAIx75) and ambulatory carotid femoral pulse wave velocity (AcfPWV). RESULTS: Mean age was 58.9 ± 12.3 years, and women accounted for 25.9%. Changes in office SBP/DBP were not different between groups (losartan and hydrochlorthiazide: -15.2 ± 15.0/-7.8 ± 8.0 vs. losartan and amlodipine: -14.9 ± 13.7/-9.2 ± 7.5 mmHg). Reduction of 24-h CSBP was not significantly different (losartan and hydrochlorthiazide: 6.4 ± 1.1 vs. losartan and amlodipine: 9.2 ± 1.1 mmHg, P = 0.074). Reduction in nocturnal AcfPWV was greater in the losartan and amlodipine group (losartan and hydrochlorthiazide: 0.09 ± 0.05 vs. losartan and amlodipine: 0.26 ± 0.05 m/s, P = 0.0216). Intraindividual SIs for CSBP were higher in the losartan and amlodipine group (0.40 ± 0.57 vs. 0.65 ± 0.74, P = 0.022). In multivariable regression analysis, smoothness index of CSBP was independently associated with the losartan and amlodipine group. In model additionally considering the changes in arterial stiffness, decrease in AcfPWV instead of the treatment group was independently associated with smoothness indices. In mediation analysis, smoothness index was fully mediated by reduction in night-time AcfPWV. CONCLUSION: Losartan and amlodipine combination was superior to the losartan and hydrochlorthiazide combination in terms of achieving higher smoothness index for CSBP after 20-week treatments. The effect of losartan and amlodipine on smoothness index was fully mediated by reduction of night-time AcfPWV.

AB - OBJECTIVES: The aim of this study was to identify associations between the smoothness index of central SBP (CSBP) and changes of ambulatory carotid femoral pulse wave velocity in response to 20-week treatments with losartan and amlodipine vs. losartan and hydrochlorthiazide combinations. METHODS: For 142 (losartan and hydrochlorthiazide: 72, losartan and hydrochlorthiazide: 70) patients examined with ambulatory central blood pressure (BP) monitoring device, we calculated smoothness indices and trough-to-peak ratios of brachial SBP, CSBP, ambulatory pulse pressure amplification (APPA), ambulatory augmentation index at heart rate 75 beats per minute (AAIx75) and ambulatory carotid femoral pulse wave velocity (AcfPWV). RESULTS: Mean age was 58.9 ± 12.3 years, and women accounted for 25.9%. Changes in office SBP/DBP were not different between groups (losartan and hydrochlorthiazide: -15.2 ± 15.0/-7.8 ± 8.0 vs. losartan and amlodipine: -14.9 ± 13.7/-9.2 ± 7.5 mmHg). Reduction of 24-h CSBP was not significantly different (losartan and hydrochlorthiazide: 6.4 ± 1.1 vs. losartan and amlodipine: 9.2 ± 1.1 mmHg, P = 0.074). Reduction in nocturnal AcfPWV was greater in the losartan and amlodipine group (losartan and hydrochlorthiazide: 0.09 ± 0.05 vs. losartan and amlodipine: 0.26 ± 0.05 m/s, P = 0.0216). Intraindividual SIs for CSBP were higher in the losartan and amlodipine group (0.40 ± 0.57 vs. 0.65 ± 0.74, P = 0.022). In multivariable regression analysis, smoothness index of CSBP was independently associated with the losartan and amlodipine group. In model additionally considering the changes in arterial stiffness, decrease in AcfPWV instead of the treatment group was independently associated with smoothness indices. In mediation analysis, smoothness index was fully mediated by reduction in night-time AcfPWV. CONCLUSION: Losartan and amlodipine combination was superior to the losartan and hydrochlorthiazide combination in terms of achieving higher smoothness index for CSBP after 20-week treatments. The effect of losartan and amlodipine on smoothness index was fully mediated by reduction of night-time AcfPWV.

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