The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients

Wan Sub Shim, Hae Jin Kim, Eun Seok Kang, Chul Woo Ahn, Sungkil Lim, Hyun Chul Lee, Bong Soo Cha

Research output: Contribution to journalArticle

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Abstract

Aims: We investigated the relation between total and differential white blood cell (WBC) count and metabolic syndrome (MS) in type 2 diabetic patients. Methods: Eight-hundred and twenty-two patients (males 430, females 392, BMI 25.4 ± 3.2 kg/m2, duration of diabetes 5.7 ± 6.8 years) were enrolled in this study. We measured total WBC count and differential count, anthropometry, blood pressure, fasting glucose, insulin and lipid profiles. Results: The number of components of MS and prevalence of MS were increased from 1st quartile to 4th quartile of WBC count. Total WBC, neutrophil, lymphocyte, monocyte and eosinophil counts were increased with the increase of number of components of MS except basophil count. Total WBC, neutrophil, lymphocyte, monocyte and eosinophil counts were higher in the patients with MS features than those without MS features. WBC count was positively correlated with waist circumference (γ = 0.134), systolic blood pressure (γ = 0.082), diastolic blood pressure (γ = 0.083), triglyceride (γ = 0.241), insulin (γ = 0.222), and HOMA-IR (γ = 0.225), and negatively with HDL cholesterol (γ = -0.146) (p < 0.05, respectively). Conclusions: Chronic inflammation, as indicated by a higher WBC count, may be related with the increased number of components of MS in type 2 diabetic patients.

Original languageEnglish
Pages (from-to)284-291
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume73
Issue number3
DOIs
Publication statusPublished - 2006 Sep 1

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Leukocyte Count
Blood Pressure
Eosinophils
Monocytes
Neutrophils
Leukocytes
Lymphocytes
Insulin
Anthropometry
Basophils
Waist Circumference
HDL Cholesterol
Fasting
Triglycerides
Inflammation
Lipids
Glucose

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Shim, Wan Sub ; Kim, Hae Jin ; Kang, Eun Seok ; Ahn, Chul Woo ; Lim, Sungkil ; Lee, Hyun Chul ; Cha, Bong Soo. / The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients. In: Diabetes Research and Clinical Practice. 2006 ; Vol. 73, No. 3. pp. 284-291.
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The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients. / Shim, Wan Sub; Kim, Hae Jin; Kang, Eun Seok; Ahn, Chul Woo; Lim, Sungkil; Lee, Hyun Chul; Cha, Bong Soo.

In: Diabetes Research and Clinical Practice, Vol. 73, No. 3, 01.09.2006, p. 284-291.

Research output: Contribution to journalArticle

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N2 - Aims: We investigated the relation between total and differential white blood cell (WBC) count and metabolic syndrome (MS) in type 2 diabetic patients. Methods: Eight-hundred and twenty-two patients (males 430, females 392, BMI 25.4 ± 3.2 kg/m2, duration of diabetes 5.7 ± 6.8 years) were enrolled in this study. We measured total WBC count and differential count, anthropometry, blood pressure, fasting glucose, insulin and lipid profiles. Results: The number of components of MS and prevalence of MS were increased from 1st quartile to 4th quartile of WBC count. Total WBC, neutrophil, lymphocyte, monocyte and eosinophil counts were increased with the increase of number of components of MS except basophil count. Total WBC, neutrophil, lymphocyte, monocyte and eosinophil counts were higher in the patients with MS features than those without MS features. WBC count was positively correlated with waist circumference (γ = 0.134), systolic blood pressure (γ = 0.082), diastolic blood pressure (γ = 0.083), triglyceride (γ = 0.241), insulin (γ = 0.222), and HOMA-IR (γ = 0.225), and negatively with HDL cholesterol (γ = -0.146) (p < 0.05, respectively). Conclusions: Chronic inflammation, as indicated by a higher WBC count, may be related with the increased number of components of MS in type 2 diabetic patients.

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