The beneficial effect of alpha-blockers for ureteral stent-related discomfort: Systematic review and network meta-analysis for alfuzosin versus tamsulosin versus placebo Endourology and technology

Jong Kyou Kwon, Kang Su Cho, Cheol Kyu Oh, Dong Hyuk Kang, Hyungmin Lee, Won Sik Ham, Young Deuk Choi, Joo Yong Lee

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Background: This study was carried out a network meta-analysis of evidence from randomized controlled trials (RCTs) to evaluate stent-related discomfort in patients with alfuzosin or tamsulosin versus placebo. Methods: Relevant RCTs were identified from electronic databases. The proceedings of appropriate meetings were also searched. Seven articles on the basis of RCTs were included in our meta-analysis. Using pairwise and network meta-analyses, comparisons were made by qualitative and quantitative syntheses. Evaluation was performed with the Ureteric Stent Symptoms Questionnaire to assess the urinary symptom score (USS) and body pain score (BPS). Results: One of the seven RCTs was at moderate risk of bias for all quality criteria; two studies had a high risk of bias. In the network meta-analysis, both alfuzosin (mean difference [MD];-4.85, 95 % confidence interval [CI];-8.53 - 1.33) and tamsulosin (MD;-8.84, 95 % CI;-13.08 - 4.31) showed lower scores compared with placebo; however, the difference in USS for alfuzosin versus tamsulosin was not significant (MD; 3.99, 95 % CI;-1.23-9.04). Alfuzosin (MD;-5.71, 95 % CI;-11.32 - 0.52) and tamsulosin (MD;-7.77, 95 % CI;-13.68 - 2.14) showed lower scores for BPS compared with placebo; however, the MD between alfuzosin and tamsulosin was not significant (MD; 2.12, 95 % CI;-4.62-8.72). In the rank-probability test, tamsulosin ranked highest for USS and BPS, and alfuzosin was second. Conclusion: The alpha-blockers significantly decreased USS and BPS in comparison with placebo. Tamsulosin might be more effective than alfuzosin.

Original languageEnglish
Article number55
JournalBMC Urology
Volume15
Issue number1
DOIs
Publication statusPublished - 2015 Jun 24

Bibliographical note

Publisher Copyright:
© 2015 Kwon et al.

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Urology

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