The benefit of post-mastectomy radiotherapy in ypNO patients after neoadjuvant chemotherapy according to molecular subtypes

Wonkyung Cho, Won Park, Doo Ho Choi, Yong Bae Kim, Jin Ho Kim, Su Ssan Kim, Kyubo Kim, Jin Hee Kim, Sung Ja Ahn, Sun Young Lee, Jeongshim Lee, Sang Won Kim, Jeanny Kwon, Ki Jung Ahn

Research output: Contribution to journalArticle

Abstract

Purpose: The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods: We identified patients initially suspected with axillary disease who achieved ypN0 following NAC. From 13 institutions of the Korean Radiation Oncology Group between 2005 and 2011, a total of 189 patients were included in the analysis. Effects of PMRT on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) were evaluated for different molecular subtypes. Results: In all patients, the prognostic effect of PMRT on LRC, DFS, or OS was not significant. Subgroups analysis showed that the effect of PMRT on LRC was different according to molecular subtype (p for interaction = 0.019). PMRT was associated with greater LRC in the luminal subtype (p = 0.046), but not in other subtypes. Conclusion: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype.

Original languageEnglish
Pages (from-to)285-296
Number of pages12
JournalJournal of Breast Cancer
Volume22
Issue number2
DOIs
Publication statusPublished - 2019 Jun

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Mastectomy
Radiotherapy
Drug Therapy
Disease-Free Survival
Survival
Radiation Oncology
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Cho, Wonkyung ; Park, Won ; Choi, Doo Ho ; Kim, Yong Bae ; Kim, Jin Ho ; Kim, Su Ssan ; Kim, Kyubo ; Kim, Jin Hee ; Ahn, Sung Ja ; Lee, Sun Young ; Lee, Jeongshim ; Kim, Sang Won ; Kwon, Jeanny ; Ahn, Ki Jung. / The benefit of post-mastectomy radiotherapy in ypNO patients after neoadjuvant chemotherapy according to molecular subtypes. In: Journal of Breast Cancer. 2019 ; Vol. 22, No. 2. pp. 285-296.
@article{51c01e985b514fed93f20eea49a8c8ac,
title = "The benefit of post-mastectomy radiotherapy in ypNO patients after neoadjuvant chemotherapy according to molecular subtypes",
abstract = "Purpose: The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods: We identified patients initially suspected with axillary disease who achieved ypN0 following NAC. From 13 institutions of the Korean Radiation Oncology Group between 2005 and 2011, a total of 189 patients were included in the analysis. Effects of PMRT on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) were evaluated for different molecular subtypes. Results: In all patients, the prognostic effect of PMRT on LRC, DFS, or OS was not significant. Subgroups analysis showed that the effect of PMRT on LRC was different according to molecular subtype (p for interaction = 0.019). PMRT was associated with greater LRC in the luminal subtype (p = 0.046), but not in other subtypes. Conclusion: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype.",
author = "Wonkyung Cho and Won Park and Choi, {Doo Ho} and Kim, {Yong Bae} and Kim, {Jin Ho} and Kim, {Su Ssan} and Kyubo Kim and Kim, {Jin Hee} and Ahn, {Sung Ja} and Lee, {Sun Young} and Jeongshim Lee and Kim, {Sang Won} and Jeanny Kwon and Ahn, {Ki Jung}",
year = "2019",
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Cho, W, Park, W, Choi, DH, Kim, YB, Kim, JH, Kim, SS, Kim, K, Kim, JH, Ahn, SJ, Lee, SY, Lee, J, Kim, SW, Kwon, J & Ahn, KJ 2019, 'The benefit of post-mastectomy radiotherapy in ypNO patients after neoadjuvant chemotherapy according to molecular subtypes', Journal of Breast Cancer, vol. 22, no. 2, pp. 285-296. https://doi.org/10.4048/jbc.2019.22.e25

The benefit of post-mastectomy radiotherapy in ypNO patients after neoadjuvant chemotherapy according to molecular subtypes. / Cho, Wonkyung; Park, Won; Choi, Doo Ho; Kim, Yong Bae; Kim, Jin Ho; Kim, Su Ssan; Kim, Kyubo; Kim, Jin Hee; Ahn, Sung Ja; Lee, Sun Young; Lee, Jeongshim; Kim, Sang Won; Kwon, Jeanny; Ahn, Ki Jung.

In: Journal of Breast Cancer, Vol. 22, No. 2, 06.2019, p. 285-296.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The benefit of post-mastectomy radiotherapy in ypNO patients after neoadjuvant chemotherapy according to molecular subtypes

AU - Cho, Wonkyung

AU - Park, Won

AU - Choi, Doo Ho

AU - Kim, Yong Bae

AU - Kim, Jin Ho

AU - Kim, Su Ssan

AU - Kim, Kyubo

AU - Kim, Jin Hee

AU - Ahn, Sung Ja

AU - Lee, Sun Young

AU - Lee, Jeongshim

AU - Kim, Sang Won

AU - Kwon, Jeanny

AU - Ahn, Ki Jung

PY - 2019/6

Y1 - 2019/6

N2 - Purpose: The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods: We identified patients initially suspected with axillary disease who achieved ypN0 following NAC. From 13 institutions of the Korean Radiation Oncology Group between 2005 and 2011, a total of 189 patients were included in the analysis. Effects of PMRT on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) were evaluated for different molecular subtypes. Results: In all patients, the prognostic effect of PMRT on LRC, DFS, or OS was not significant. Subgroups analysis showed that the effect of PMRT on LRC was different according to molecular subtype (p for interaction = 0.019). PMRT was associated with greater LRC in the luminal subtype (p = 0.046), but not in other subtypes. Conclusion: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype.

AB - Purpose: The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods: We identified patients initially suspected with axillary disease who achieved ypN0 following NAC. From 13 institutions of the Korean Radiation Oncology Group between 2005 and 2011, a total of 189 patients were included in the analysis. Effects of PMRT on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) were evaluated for different molecular subtypes. Results: In all patients, the prognostic effect of PMRT on LRC, DFS, or OS was not significant. Subgroups analysis showed that the effect of PMRT on LRC was different according to molecular subtype (p for interaction = 0.019). PMRT was associated with greater LRC in the luminal subtype (p = 0.046), but not in other subtypes. Conclusion: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype.

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