The biocompatibility of nanostructured calcium phosphate coated on micro-arc oxidized titanium

Yan Li, In Seop Lee, Fu Zhai Cui, Seong Ho Choi

Research output: Contribution to journalArticlepeer-review

150 Citations (Scopus)


To achieve improved osseointegration, there have been many efforts to modify the surface composition and topography of dental implants. Recently, the anodic oxidation treatment of titanium (Ti) has attracted a great deal of attention. Meanwhile, calcium phosphate is commonly applied to metallic implants as a coating material for fast fixation and firm implant-bone attachment on the account of its demonstrated bioactive and osteoconductive properties. In the present study, anodized surface and calcium phosphate deposition by electron beam evaporation were combined. Nanostructured calcium phosphate film was deposited on the micro-arc oxidized Ti. New apatite layer formed easily on the coated film when incubating in DPBS solution at 37 °C. By adding basic fibroblast growth factor (bFGF) in the DPBS solution, the bFGF could be immobilized in the newly formed apatite layer. The coated film enhanced osseointegration of Ti implants in vivo.

Original languageEnglish
Pages (from-to)2025-2032
Number of pages8
Issue number13
Publication statusPublished - 2008 May

Bibliographical note

Funding Information:
This work was supported by a grant (code #: 07K1501-01620) from Center for Nanostructured Materials Technology under 21st Century Frontier R&D Program of the Ministry of Science and Technology, Korea.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Ceramics and Composites
  • Biomaterials
  • Mechanics of Materials


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