The biological activities of (1,3)-(1,6)-β-D-glucan and porous electrospun PLGA membranes containing β-glucan in human dermal fibroblasts and adipose tissue-derived stem cells

Yeon I. Woo, Bong Joo Park, Hye Lee Kim, Mi Hee Lee, Jungsung Kim, Young Il Yang, Jung Koo Kim, Kazufumi Tsubaki, Dong Wook Han, Jong Chul Park

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29 Citations (Scopus)

Abstract

In this study, we investigated the possible roles of (1,3)-(1,6)-β-D- glucan (β-glucan) and porous electrospun poly-lactide-co-glycolide (PLGA) membranes containing β-glucan for skin wound healing, especially their effect on adult human dermal fibroblast (aHDF) and adipose tissue-derived stem cell (ADSC) activation, proliferation, migration, collagen gel contraction and biological safety tests of the prepared membrane. This study demonstrated that β-glucan and porous PLGA membranes containing β-glucan have enhanced the cellular responses, proliferation and migration, of aHDFs and ADSCs and the result of a collagen gel contraction assay also revealed that collagen gels contract strongly after 4 h post-gelation incubation with β-glucan. Furthermore, we confirmed that porous PLGA membranes containing β-glucan are biologically safe for wound healing study. These results indicate that the porous PLGA membranes containing β-glucan interacted favorably with the membrane and the topical administration of β-glucan was useful in promoting wound healing. Therefore, our study suggests that β-glucan and porous PLGA membranes containing β-glucan may be useful as a material for enhancing wound healing.

Original languageEnglish
Article number044109
JournalBiomedical Materials
Volume5
Issue number4
DOIs
Publication statusPublished - 2010 Aug

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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