The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects

Yun Young Chang, Surangi Dissanayake, Jeong Ho Yun, Ui Won Jung, Chang Sung Kim, Kyeong Jun Park, Jung Kiu Chai, Seong Ho Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. Methods: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group). Results: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing. Conclusions: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalJournal of Periodontal and Implant Science
Volume41
Issue number3
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

Cyanoacrylates
Rabbits
calcium phosphate
Control Groups
Architectural Accessibility
Porifera
Osteogenesis
Collagen

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Periodontics

Cite this

Chang, Yun Young ; Dissanayake, Surangi ; Yun, Jeong Ho ; Jung, Ui Won ; Kim, Chang Sung ; Park, Kyeong Jun ; Chai, Jung Kiu ; Choi, Seong Ho. / The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects. In: Journal of Periodontal and Implant Science. 2011 ; Vol. 41, No. 3. pp. 123-130.
@article{23bbd4166d1849f28bdbdbc138382d6d,
title = "The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects",
abstract = "Purpose: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. Methods: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group). Results: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing. Conclusions: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved.",
author = "Chang, {Yun Young} and Surangi Dissanayake and Yun, {Jeong Ho} and Jung, {Ui Won} and Kim, {Chang Sung} and Park, {Kyeong Jun} and Chai, {Jung Kiu} and Choi, {Seong Ho}",
year = "2011",
month = "6",
day = "1",
doi = "10.5051/jpis.2011.41.3.123",
language = "English",
volume = "41",
pages = "123--130",
journal = "Journal of Periodontal and Implant Science",
issn = "2093-2278",
publisher = "Korean Academy of Periodontology",
number = "3",

}

The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects. / Chang, Yun Young; Dissanayake, Surangi; Yun, Jeong Ho; Jung, Ui Won; Kim, Chang Sung; Park, Kyeong Jun; Chai, Jung Kiu; Choi, Seong Ho.

In: Journal of Periodontal and Implant Science, Vol. 41, No. 3, 01.06.2011, p. 123-130.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects

AU - Chang, Yun Young

AU - Dissanayake, Surangi

AU - Yun, Jeong Ho

AU - Jung, Ui Won

AU - Kim, Chang Sung

AU - Park, Kyeong Jun

AU - Chai, Jung Kiu

AU - Choi, Seong Ho

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Purpose: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. Methods: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group). Results: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing. Conclusions: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved.

AB - Purpose: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. Methods: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group). Results: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing. Conclusions: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved.

UR - http://www.scopus.com/inward/record.url?scp=84859763686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859763686&partnerID=8YFLogxK

U2 - 10.5051/jpis.2011.41.3.123

DO - 10.5051/jpis.2011.41.3.123

M3 - Article

C2 - 21811687

AN - SCOPUS:84859763686

VL - 41

SP - 123

EP - 130

JO - Journal of Periodontal and Implant Science

JF - Journal of Periodontal and Implant Science

SN - 2093-2278

IS - 3

ER -