TY - JOUR
T1 - The biomimetic apatite-cefalotin coatings on modifed titanium
AU - Kang, Min Kyung
AU - Lee, Sang Bae
AU - Moon, Seung Kyun
AU - Kim, Kwang Mahn
AU - Kim, Kyoung Nam
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/1/21
Y1 - 2012/1/21
N2 - Dental implant failure often occurs due to oral bacterial infection. The aim of this study was to demonstrate that antibiotic effcacy could be enhanced with modifed titanium. First, the titanium was modifed by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. Release of antibiotic was evaluated by UV/VIS spectrometry, and the antibacterial effect was evaluated on Streptococcus mutans. After the second coating step, we observed a thick homogeneous apatite layer that contained the antibiotic, cefalotin. The titanium formed a rutile phase after the heat treatment, and a carbonated apatite phase appeared after biomimetic coating. We found that the modifed titanium increased the loading of cefalotin onto the hydroxyapatite coated surface. The results suggested that modifed titanium coated with a cefalotin using biomimetic coating method might be useful for preventing local post-surgical implant infections.
AB - Dental implant failure often occurs due to oral bacterial infection. The aim of this study was to demonstrate that antibiotic effcacy could be enhanced with modifed titanium. First, the titanium was modifed by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. Release of antibiotic was evaluated by UV/VIS spectrometry, and the antibacterial effect was evaluated on Streptococcus mutans. After the second coating step, we observed a thick homogeneous apatite layer that contained the antibiotic, cefalotin. The titanium formed a rutile phase after the heat treatment, and a carbonated apatite phase appeared after biomimetic coating. We found that the modifed titanium increased the loading of cefalotin onto the hydroxyapatite coated surface. The results suggested that modifed titanium coated with a cefalotin using biomimetic coating method might be useful for preventing local post-surgical implant infections.
UR - http://www.scopus.com/inward/record.url?scp=84863022728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863022728&partnerID=8YFLogxK
U2 - 10.4012/dmj.2011-131
DO - 10.4012/dmj.2011-131
M3 - Article
C2 - 22277612
AN - SCOPUS:84863022728
VL - 31
SP - 98
EP - 105
JO - Dental Materials Journal
JF - Dental Materials Journal
SN - 0287-4547
IS - 1
ER -