The biomimetic apatite-cefalotin coatings on modifed titanium

Dental implant failure often occurs due to oral bacterial infection. The aim of this study was to demonstrate that antibiotic effcacy could be enhanced with modifed titanium. First, the titanium was modifed by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. Release of antibiotic was evaluated by UV/VIS spectrometry, and the antibacterial effect was evaluated on Streptococcus mutans. After the second coating step, we observed a thick homogeneous apatite layer that contained the antibiotic, cefalotin. The titanium formed a rutile phase after the heat treatment, and a carbonated apatite phase appeared after biomimetic coating. We found that the modifed titanium increased the loading of cefalotin onto the hydroxyapatite coated surface. The results suggested that modifed titanium coated with a cefalotin using biomimetic coating method might be useful for preventing local post-surgical implant infections.