The brain-enriched microRNA miR-9-3p regulates synaptic plasticity and memory

Su Eon Sim, Chae Seok Lim, Jae Ick Kim, Daekwan Seo, Heejung Chun, Nam Kyung Yu, Jaehyun Lee, Sukjae Joshua Kang, Hyoung Gon Ko, Jun Hyeok Choi, Tae Hyun Kim, Eun Hae Jang, Joohyun Han, Myeong Seong Bak, Jong Eun Park, Deok Jin Jang, Daehyun Baek, Yong Seok Lee, Bong Kiun Kaang

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression in many tissues. Although a number of brain-enriched miRNAs have been identified, only a few specific miRNAs have been revealed as critical regulators of synaptic plasticity, learning, and memory. miR-9-5p/3p are brain-enriched miRNAs known to regulate development and their changes have been implicated in several neurological disorders, yet their role in mature neurons in mice is largely unknown. Here, we report that inhibition of miR-9-3p, but not miR-9-5p, impaired hippocampal long-term potentiation (LTP) without affecting basal synaptic transmission. Moreover, inhibition of miR-9-3p in the hippocampus resulted in learning and memory deficits. Furthermore, miR-9-3p inhibition increased the expression of the LTP-related genes Dmd and SAP97, the expression levels of which are negatively correlated with LTP. These results suggest that miR-9-3p-mediated gene regulation plays important roles in synaptic plasticity and hippocampus-dependent memory.

Original languageEnglish
Pages (from-to)8541-8552
Number of pages12
JournalJournal of Neuroscience
Volume36
Issue number33
DOIs
Publication statusPublished - 2016 Aug 17

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea funded by the Korean government (Grant 2012R1A3A1050385 to B.-K.K.) and the Ministry of Health and Welfare of the Republic of Korea (Grant HI14C-1922-010014 to Y.-S.L.). We thank Dr. V. Narry Kim for helpful discussion.

Publisher Copyright:
© 2016 the authors.

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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