The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease

M. K. Sunwoo, S. Jeon, J. H. Ham, J. Y. Hong, J. E. Lee, J. M. Lee, Y. H. Sohn, philhyu Lee

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background and purpose: To evaluate whether white matter hyperintensities (WMHs) may act as an independent predictor for progression of cognitive status, the authors analyzed the longitudinal effects of WMHs on cognitive dysfunction in non-demented patients with Parkinson's disease (PD). Methods: A total of 111 patients with PD were enrolled, including subjects with mild cognitive impairment (MCI, n = 65) and cognitively normal subjects (CN, n = 46). These individuals were classified as MCI converters (n = 22) or MCI non-converters (n = 43) and CN converters (n = 18) or CN non-converters (n = 28) based on whether they were subsequently diagnosed with PD dementia or PD-MCI during a minimum 24-month follow-up. The WMH burden and the Cholinergic Pathway Hyperintensities Scale (CHIPS) and their relationships to longitudinal changes in cognitive performance were examined. Results: PD-MCI converters had larger WMH volume (14421.0 vs. 5180.4, P < 0.001) and higher CHIPS score (22.6 vs. 11.2, P = 0.001) compared with PD-MCI non-converters. Logistic regression analysis revealed in patients with PD-MCI that WMH volume (odds ratio 1.616, P = 0.009) and CHIPS score (odds ratio 1.084, P = 0.007) were independently associated with PD dementia conversion. However, WMH volume and CHIPS score did not differ between PD-CN converters and PD-CN non-converters. In patients with PD-MCI, both WMH volume and CHIPS score were closely associated with longitudinal decline in general cognition, semantic fluency and Stroop test scores. Conclusions: The present study demonstrates that WMH burden is a significant predictor of conversion from PD-MCI to PD dementia and is related to ongoing decline in frontal-lobe-based cognitive performance.

Original languageEnglish
JournalEuropean Journal of Neurology
Volume21
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Parkinson Disease
Cholinergic Agents
Dementia
Cognitive Dysfunction
White Matter
Odds Ratio
Stroop Test
Frontal Lobe
Semantics
Cognition
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Sunwoo, M. K. ; Jeon, S. ; Ham, J. H. ; Hong, J. Y. ; Lee, J. E. ; Lee, J. M. ; Sohn, Y. H. ; Lee, philhyu. / The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease. In: European Journal of Neurology. 2014 ; Vol. 21, No. 6.
@article{dda111e89eb743d7bd224d7d9fe8647e,
title = "The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease",
abstract = "Background and purpose: To evaluate whether white matter hyperintensities (WMHs) may act as an independent predictor for progression of cognitive status, the authors analyzed the longitudinal effects of WMHs on cognitive dysfunction in non-demented patients with Parkinson's disease (PD). Methods: A total of 111 patients with PD were enrolled, including subjects with mild cognitive impairment (MCI, n = 65) and cognitively normal subjects (CN, n = 46). These individuals were classified as MCI converters (n = 22) or MCI non-converters (n = 43) and CN converters (n = 18) or CN non-converters (n = 28) based on whether they were subsequently diagnosed with PD dementia or PD-MCI during a minimum 24-month follow-up. The WMH burden and the Cholinergic Pathway Hyperintensities Scale (CHIPS) and their relationships to longitudinal changes in cognitive performance were examined. Results: PD-MCI converters had larger WMH volume (14421.0 vs. 5180.4, P < 0.001) and higher CHIPS score (22.6 vs. 11.2, P = 0.001) compared with PD-MCI non-converters. Logistic regression analysis revealed in patients with PD-MCI that WMH volume (odds ratio 1.616, P = 0.009) and CHIPS score (odds ratio 1.084, P = 0.007) were independently associated with PD dementia conversion. However, WMH volume and CHIPS score did not differ between PD-CN converters and PD-CN non-converters. In patients with PD-MCI, both WMH volume and CHIPS score were closely associated with longitudinal decline in general cognition, semantic fluency and Stroop test scores. Conclusions: The present study demonstrates that WMH burden is a significant predictor of conversion from PD-MCI to PD dementia and is related to ongoing decline in frontal-lobe-based cognitive performance.",
author = "Sunwoo, {M. K.} and S. Jeon and Ham, {J. H.} and Hong, {J. Y.} and Lee, {J. E.} and Lee, {J. M.} and Sohn, {Y. H.} and philhyu Lee",
year = "2014",
month = "1",
day = "1",
doi = "10.1111/ene.12412",
language = "English",
volume = "21",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "6",

}

The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease. / Sunwoo, M. K.; Jeon, S.; Ham, J. H.; Hong, J. Y.; Lee, J. E.; Lee, J. M.; Sohn, Y. H.; Lee, philhyu.

In: European Journal of Neurology, Vol. 21, No. 6, 01.01.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease

AU - Sunwoo, M. K.

AU - Jeon, S.

AU - Ham, J. H.

AU - Hong, J. Y.

AU - Lee, J. E.

AU - Lee, J. M.

AU - Sohn, Y. H.

AU - Lee, philhyu

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background and purpose: To evaluate whether white matter hyperintensities (WMHs) may act as an independent predictor for progression of cognitive status, the authors analyzed the longitudinal effects of WMHs on cognitive dysfunction in non-demented patients with Parkinson's disease (PD). Methods: A total of 111 patients with PD were enrolled, including subjects with mild cognitive impairment (MCI, n = 65) and cognitively normal subjects (CN, n = 46). These individuals were classified as MCI converters (n = 22) or MCI non-converters (n = 43) and CN converters (n = 18) or CN non-converters (n = 28) based on whether they were subsequently diagnosed with PD dementia or PD-MCI during a minimum 24-month follow-up. The WMH burden and the Cholinergic Pathway Hyperintensities Scale (CHIPS) and their relationships to longitudinal changes in cognitive performance were examined. Results: PD-MCI converters had larger WMH volume (14421.0 vs. 5180.4, P < 0.001) and higher CHIPS score (22.6 vs. 11.2, P = 0.001) compared with PD-MCI non-converters. Logistic regression analysis revealed in patients with PD-MCI that WMH volume (odds ratio 1.616, P = 0.009) and CHIPS score (odds ratio 1.084, P = 0.007) were independently associated with PD dementia conversion. However, WMH volume and CHIPS score did not differ between PD-CN converters and PD-CN non-converters. In patients with PD-MCI, both WMH volume and CHIPS score were closely associated with longitudinal decline in general cognition, semantic fluency and Stroop test scores. Conclusions: The present study demonstrates that WMH burden is a significant predictor of conversion from PD-MCI to PD dementia and is related to ongoing decline in frontal-lobe-based cognitive performance.

AB - Background and purpose: To evaluate whether white matter hyperintensities (WMHs) may act as an independent predictor for progression of cognitive status, the authors analyzed the longitudinal effects of WMHs on cognitive dysfunction in non-demented patients with Parkinson's disease (PD). Methods: A total of 111 patients with PD were enrolled, including subjects with mild cognitive impairment (MCI, n = 65) and cognitively normal subjects (CN, n = 46). These individuals were classified as MCI converters (n = 22) or MCI non-converters (n = 43) and CN converters (n = 18) or CN non-converters (n = 28) based on whether they were subsequently diagnosed with PD dementia or PD-MCI during a minimum 24-month follow-up. The WMH burden and the Cholinergic Pathway Hyperintensities Scale (CHIPS) and their relationships to longitudinal changes in cognitive performance were examined. Results: PD-MCI converters had larger WMH volume (14421.0 vs. 5180.4, P < 0.001) and higher CHIPS score (22.6 vs. 11.2, P = 0.001) compared with PD-MCI non-converters. Logistic regression analysis revealed in patients with PD-MCI that WMH volume (odds ratio 1.616, P = 0.009) and CHIPS score (odds ratio 1.084, P = 0.007) were independently associated with PD dementia conversion. However, WMH volume and CHIPS score did not differ between PD-CN converters and PD-CN non-converters. In patients with PD-MCI, both WMH volume and CHIPS score were closely associated with longitudinal decline in general cognition, semantic fluency and Stroop test scores. Conclusions: The present study demonstrates that WMH burden is a significant predictor of conversion from PD-MCI to PD dementia and is related to ongoing decline in frontal-lobe-based cognitive performance.

UR - http://www.scopus.com/inward/record.url?scp=84899911663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899911663&partnerID=8YFLogxK

U2 - 10.1111/ene.12412

DO - 10.1111/ene.12412

M3 - Article

C2 - 24661277

AN - SCOPUS:84899911663

VL - 21

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 6

ER -