The Caenorhabditis elegans XPA homolog of human XPA

Hye Kyung Park, Jong Sung Yook, Hyeon Sook Koo, In Soon Choi, Byungchan Ahn

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The Xeroderma pigmentosum complementation group A (XPA) protein that is indispensable for nucleotide excision repair of DNA damage in eukaryotes participates in photoproduct recognition. A search of the current Caenorhabditis elegans database allowed us to identify a good candidate for the XPA protein homolog. We cloned a complete cDNA of C. elegans XPA (Ce-XPA) by using RT-PCR. Northern blot analysis showed that the Ce-xpa gene is expressed in all of the stages, including embryos. Ce-XPA encodes a 241-amino acid protein that is homologous to all known eukaryotic XPA. Ce-XPA RNAi caused embryonic lethality and survival lethality to UV radiation. This result suggests that Ce-XPA is involved in the repair of UV-damaged DNA in C. elegans.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalMolecules and cells
Volume14
Issue number1
Publication statusPublished - 2002 Aug

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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    Park, H. K., Yook, J. S., Koo, H. S., Choi, I. S., & Ahn, B. (2002). The Caenorhabditis elegans XPA homolog of human XPA. Molecules and cells, 14(1), 50-55.