The Characteristics of Bone Metastasis in Patients with Colorectal Cancer: A Long-Term Report from a Single Institution

Se Jin Baek, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Namkyu Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Bone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC. Materials and methods: We performed a chart review of 63 patients (1.1 %) with bone metastasis among 5479 patients who underwent surgery for CRC. Results: Most patients were stage 3 (17.5 %) or 4 (73.0 %), and 32 patients (50.8 %) were diagnosed with bone metastasis at initial diagnoses of CRC. Thirty-one patients developed bone metastasis during the follow-up period with median 10.1-month interval. PET-CT was most frequently used for the diagnosis of bone metastasis (71.4 %), and the spine was the most commonly involved site (77.8 %). Most patients had multiple bone metastases (73.0 %) and other metastases (87.3 %). Bone pain was the most common skeletal-related event (25.4 %), and patients were treated with radiation (25.4 %), surgery (14.3 %), or bisphosphonate (6.3 %). The median survival time was 17.8 months, and the 5-year survival rate was 5.7 %. In the multivariate analysis, the risk factors for survival included initial bone metastasis (hazard ratio [HR] 3.03; P < 0.001) and bone metastasis from colon cancer (HR 1.87; P = 0.04). Conclusion: Bone metastasis in patients with CRC is extremely rare and shows poor prognosis.

Original languageEnglish
Pages (from-to)982-986
Number of pages5
JournalWorld Journal of Surgery
Volume40
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

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Colorectal Neoplasms
Neoplasm Metastasis
Bone and Bones
Survival
Diphosphonates
Colonic Neoplasms
Spine
Multivariate Analysis
Survival Rate
Radiation
Pain

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Baek, Se Jin ; Hur, Hyuk ; Min, Byung Soh ; Baik, Seung Hyuk ; Lee, Kang Young ; Kim, Namkyu. / The Characteristics of Bone Metastasis in Patients with Colorectal Cancer : A Long-Term Report from a Single Institution. In: World Journal of Surgery. 2016 ; Vol. 40, No. 4. pp. 982-986.
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title = "The Characteristics of Bone Metastasis in Patients with Colorectal Cancer: A Long-Term Report from a Single Institution",
abstract = "Background: Bone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC. Materials and methods: We performed a chart review of 63 patients (1.1 {\%}) with bone metastasis among 5479 patients who underwent surgery for CRC. Results: Most patients were stage 3 (17.5 {\%}) or 4 (73.0 {\%}), and 32 patients (50.8 {\%}) were diagnosed with bone metastasis at initial diagnoses of CRC. Thirty-one patients developed bone metastasis during the follow-up period with median 10.1-month interval. PET-CT was most frequently used for the diagnosis of bone metastasis (71.4 {\%}), and the spine was the most commonly involved site (77.8 {\%}). Most patients had multiple bone metastases (73.0 {\%}) and other metastases (87.3 {\%}). Bone pain was the most common skeletal-related event (25.4 {\%}), and patients were treated with radiation (25.4 {\%}), surgery (14.3 {\%}), or bisphosphonate (6.3 {\%}). The median survival time was 17.8 months, and the 5-year survival rate was 5.7 {\%}. In the multivariate analysis, the risk factors for survival included initial bone metastasis (hazard ratio [HR] 3.03; P < 0.001) and bone metastasis from colon cancer (HR 1.87; P = 0.04). Conclusion: Bone metastasis in patients with CRC is extremely rare and shows poor prognosis.",
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The Characteristics of Bone Metastasis in Patients with Colorectal Cancer : A Long-Term Report from a Single Institution. / Baek, Se Jin; Hur, Hyuk; Min, Byung Soh; Baik, Seung Hyuk; Lee, Kang Young; Kim, Namkyu.

In: World Journal of Surgery, Vol. 40, No. 4, 01.04.2016, p. 982-986.

Research output: Contribution to journalArticle

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AU - Lee, Kang Young

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N2 - Background: Bone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC. Materials and methods: We performed a chart review of 63 patients (1.1 %) with bone metastasis among 5479 patients who underwent surgery for CRC. Results: Most patients were stage 3 (17.5 %) or 4 (73.0 %), and 32 patients (50.8 %) were diagnosed with bone metastasis at initial diagnoses of CRC. Thirty-one patients developed bone metastasis during the follow-up period with median 10.1-month interval. PET-CT was most frequently used for the diagnosis of bone metastasis (71.4 %), and the spine was the most commonly involved site (77.8 %). Most patients had multiple bone metastases (73.0 %) and other metastases (87.3 %). Bone pain was the most common skeletal-related event (25.4 %), and patients were treated with radiation (25.4 %), surgery (14.3 %), or bisphosphonate (6.3 %). The median survival time was 17.8 months, and the 5-year survival rate was 5.7 %. In the multivariate analysis, the risk factors for survival included initial bone metastasis (hazard ratio [HR] 3.03; P < 0.001) and bone metastasis from colon cancer (HR 1.87; P = 0.04). Conclusion: Bone metastasis in patients with CRC is extremely rare and shows poor prognosis.

AB - Background: Bone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC. Materials and methods: We performed a chart review of 63 patients (1.1 %) with bone metastasis among 5479 patients who underwent surgery for CRC. Results: Most patients were stage 3 (17.5 %) or 4 (73.0 %), and 32 patients (50.8 %) were diagnosed with bone metastasis at initial diagnoses of CRC. Thirty-one patients developed bone metastasis during the follow-up period with median 10.1-month interval. PET-CT was most frequently used for the diagnosis of bone metastasis (71.4 %), and the spine was the most commonly involved site (77.8 %). Most patients had multiple bone metastases (73.0 %) and other metastases (87.3 %). Bone pain was the most common skeletal-related event (25.4 %), and patients were treated with radiation (25.4 %), surgery (14.3 %), or bisphosphonate (6.3 %). The median survival time was 17.8 months, and the 5-year survival rate was 5.7 %. In the multivariate analysis, the risk factors for survival included initial bone metastasis (hazard ratio [HR] 3.03; P < 0.001) and bone metastasis from colon cancer (HR 1.87; P = 0.04). Conclusion: Bone metastasis in patients with CRC is extremely rare and shows poor prognosis.

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