The chemical constituents from twigs of Lindera glauca (Siebold & Zucc.) Blume and their antiviral activities

Seon Ju Park; Jae Hyoung Song; Nguyen Xuan Nhiem; Hyun Jeong Ko; Seung Hyun Kim

doi:10.1016/j.phytol.2018.04.008

The chemical constituents from twigs of Lindera glauca (Siebold & Zucc.) Blume and their antiviral activities

Seon Ju Park, Jae Hyoung Song, Nguyen Xuan Nhiem, Hyun Jeong Ko, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Four new compounds (1–3 and 5), along with 17 known compounds, were isolated from the twigs of Lindera glauca (Siebold & Zucc.) Blume. The absolute configuration of compound 4 was determined for the first time in the present study. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their antiviral activities against HRV1B-, CVB3-, and PR8-infected Vero cells. Among the tested compounds, (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol exhibited the most consistent and effective antiviral activities on both HRV1B and CVB3 infected cells.

Original language	English
Pages (from-to)	74-80
Number of pages	7
Journal	Phytochemistry Letters
Volume	25
DOIs	https://doi.org/10.1016/j.phytol.2018.04.008
Publication status	Published - 2018 Jun

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant [ NRF-2016R1A2B4006742 and NRF-2017R1A6A3A11029000 ] funded by the Ministry of Education, Science and Technology , Republic of Korea, and the Basic Science Research Program for Young Researchers funded by the Richwood Pharmaceutical Company , Republic of Korea.

Publisher Copyright:
© 2018

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2018.04.008

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title = "The chemical constituents from twigs of Lindera glauca (Siebold & Zucc.) Blume and their antiviral activities",

abstract = "Four new compounds (1–3 and 5), along with 17 known compounds, were isolated from the twigs of Lindera glauca (Siebold & Zucc.) Blume. The absolute configuration of compound 4 was determined for the first time in the present study. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their antiviral activities against HRV1B-, CVB3-, and PR8-infected Vero cells. Among the tested compounds, (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol exhibited the most consistent and effective antiviral activities on both HRV1B and CVB3 infected cells.",

author = "Park, {Seon Ju} and Song, {Jae Hyoung} and Nhiem, {Nguyen Xuan} and Ko, {Hyun Jeong} and Kim, {Seung Hyun}",

note = "Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant [ NRF-2016R1A2B4006742 and NRF-2017R1A6A3A11029000 ] funded by the Ministry of Education, Science and Technology , Republic of Korea, and the Basic Science Research Program for Young Researchers funded by the Richwood Pharmaceutical Company , Republic of Korea. Publisher Copyright: {\textcopyright} 2018",

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doi = "10.1016/j.phytol.2018.04.008",

language = "English",

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AU - Park, Seon Ju

AU - Song, Jae Hyoung

AU - Nhiem, Nguyen Xuan

AU - Ko, Hyun Jeong

AU - Kim, Seung Hyun

N1 - Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant [ NRF-2016R1A2B4006742 and NRF-2017R1A6A3A11029000 ] funded by the Ministry of Education, Science and Technology , Republic of Korea, and the Basic Science Research Program for Young Researchers funded by the Richwood Pharmaceutical Company , Republic of Korea. Publisher Copyright: © 2018

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N2 - Four new compounds (1–3 and 5), along with 17 known compounds, were isolated from the twigs of Lindera glauca (Siebold & Zucc.) Blume. The absolute configuration of compound 4 was determined for the first time in the present study. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their antiviral activities against HRV1B-, CVB3-, and PR8-infected Vero cells. Among the tested compounds, (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol exhibited the most consistent and effective antiviral activities on both HRV1B and CVB3 infected cells.

AB - Four new compounds (1–3 and 5), along with 17 known compounds, were isolated from the twigs of Lindera glauca (Siebold & Zucc.) Blume. The absolute configuration of compound 4 was determined for the first time in the present study. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their antiviral activities against HRV1B-, CVB3-, and PR8-infected Vero cells. Among the tested compounds, (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol exhibited the most consistent and effective antiviral activities on both HRV1B and CVB3 infected cells.

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VL - 25

SP - 74

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JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

The chemical constituents from twigs of Lindera glauca (Siebold & Zucc.) Blume and their antiviral activities

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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