The clinical and immunogenetic characteristics of adult-onset type 1 diabetes mellitus in Korea

C. S. Kim, M. K. Song, J. S. Park, M. H. Cho, H. J. Kim, J. S. Nam, E. S. Kang, C. W. Ahn, B. S. Cha, E. G. Lee, S. K. Lim, K. R. Kim, H. C. Lee, K. B. Huh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although the HLA class II alleles and immunological abnormalities are associated with type 1 diabetes mellitus (T1DM) in all racial groups, there are considerable variations in the genotypes and the prevalence of autoantibodies. In order to investigate the characteristics of the immunogenetic patterns and to use these as an early diagnostic tool and guideline for a therapeutic plan, we examined the clinical characteristics and the patterns of anti-GAD antibody (GADA), IA-2 antibody (IA-2A), HLA-DR and HLA-DQ in Korean adult-onset T1DM patients. Adult-onset patients had higher serum C-peptide levels than child-onset patients. In adult-onset patients, the prevalence of GADA and IA-2A were 59.5% and 15.3% respectively, and increased frequencies of HLADR4 and-DR9 were found. The frequencies of HLADQA1,-DQB1 and-DQ heterodimers were similar to those of the control, but child-onset patients had high frequencies of the HLA-DR3,-DR4,-DR9, DQA1*0301, DQA1*0501 and DQB1*0201 genotypes. In conclusion, Korean adult-onset T1DM patients had a lower prevalence of GADA, which was comparable to that found in Caucasian patients. The detection of GADA might help to predict the insulin dependency of adult-onset diabetes. Difference in the frequencies of diabetes associated with HLA type suggests that there might be a heterogeneity in the pathogenesis of diabetes according to the age of onset.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalActa Diabetologica
Volume44
Issue number2
DOIs
Publication statusPublished - 2007 Jul 1

Fingerprint

Immunogenetics
Korea
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Antibodies
Genotype
HLA-DR3 Antigen
HLA-DR4 Antigen
HLA-DQ Antigens
C-Peptide
HLA-DR Antigens
Age of Onset
Autoantibodies
Anti-Idiotypic Antibodies
Alleles
Guidelines
Insulin
Serum

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kim, C. S., Song, M. K., Park, J. S., Cho, M. H., Kim, H. J., Nam, J. S., ... Huh, K. B. (2007). The clinical and immunogenetic characteristics of adult-onset type 1 diabetes mellitus in Korea. Acta Diabetologica, 44(2), 45-54. https://doi.org/10.1007/s00592-007-0241-y
Kim, C. S. ; Song, M. K. ; Park, J. S. ; Cho, M. H. ; Kim, H. J. ; Nam, J. S. ; Kang, E. S. ; Ahn, C. W. ; Cha, B. S. ; Lee, E. G. ; Lim, S. K. ; Kim, K. R. ; Lee, H. C. ; Huh, K. B. / The clinical and immunogenetic characteristics of adult-onset type 1 diabetes mellitus in Korea. In: Acta Diabetologica. 2007 ; Vol. 44, No. 2. pp. 45-54.
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Kim, CS, Song, MK, Park, JS, Cho, MH, Kim, HJ, Nam, JS, Kang, ES, Ahn, CW, Cha, BS, Lee, EG, Lim, SK, Kim, KR, Lee, HC & Huh, KB 2007, 'The clinical and immunogenetic characteristics of adult-onset type 1 diabetes mellitus in Korea', Acta Diabetologica, vol. 44, no. 2, pp. 45-54. https://doi.org/10.1007/s00592-007-0241-y

The clinical and immunogenetic characteristics of adult-onset type 1 diabetes mellitus in Korea. / Kim, C. S.; Song, M. K.; Park, J. S.; Cho, M. H.; Kim, H. J.; Nam, J. S.; Kang, E. S.; Ahn, C. W.; Cha, B. S.; Lee, E. G.; Lim, S. K.; Kim, K. R.; Lee, H. C.; Huh, K. B.

In: Acta Diabetologica, Vol. 44, No. 2, 01.07.2007, p. 45-54.

Research output: Contribution to journalArticle

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T1 - The clinical and immunogenetic characteristics of adult-onset type 1 diabetes mellitus in Korea

AU - Kim, C. S.

AU - Song, M. K.

AU - Park, J. S.

AU - Cho, M. H.

AU - Kim, H. J.

AU - Nam, J. S.

AU - Kang, E. S.

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AU - Lee, E. G.

AU - Lim, S. K.

AU - Kim, K. R.

AU - Lee, H. C.

AU - Huh, K. B.

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