The clinical characteristics and prognosis of Crohn's disease in Korean patients showing proximal small bowel involvement: Results from the CONNECT Study

One Zoong Kim, Dong Soo Han, Chan Hyuk Park, Chang Soo Eun, You Sun Kim, Young Ho Kim, Jae Hee Cheon, Byong Duk Ye, Joo Sung Kim

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background/Aims: We aimed to evaluate the clinical characteristics and prognosis of Crohn's disease (CD) in patients who showed proximal small bowel involvement using a nationwide Korean CD cohort. Methods: We reviewed the data from a cohort of patients diagnosed with CD. The clinical outcomes of patients were evaluated according to the presence of proximal small bowel involvement. Results: Among 1,329 patients with CD for whom complete disease location data were available, 222 patients (16.7%) showed involvement of the proximal small bowel. Compared to patients without proximal small bowel involvement, those with small bowel involvement were more likely to display stricturing behavior (19.8% vs 12.7%, p=0.020). The surgery-free survival of patients who showed proximal small bowel involvement was inferior to that of patients without proximal small bowel involvement (10-year surgery-free survival: 58.4% vs 67.7%, respectively, p<0.001). Additionally, upper gastrointestinal involvement was more common in patients with proximal small bowel involvement than in those without involvement (odds ratio, 1.643; 95% confidence interval, 1.008 to 2.677). Conclusions: Proximal small bowel involvement is a poor prognostic factor for the surgery-free survival of Korean patients with CD. Proximal small bowel involvement should be evaluated in patients with CD for predicting long-Term clinical outcomes.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalGut and liver
Volume12
Issue number1
DOIs
Publication statusPublished - 2018 Jan

Bibliographical note

Funding Information:
This work was supported by a research program funded by the Korean Centers for Disease Control and Prevention (2016-E63001-00) and a Grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A120176) (D.S.H.).

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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