The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response

A study based on a multicenter database in Korea

Kwang Jae Lee, Kee Wook Jung, Seung Jae Myung, Hyun Jin Kim, Na Young Kim, Young Hoon Yoon, Chong Il Sohn, Jung Eun Shin, Yu Kyung Cho, Soo Jin Hong, Tae Hee Lee, Kyung Sik Park, Hye Kyung Jung, Chang Hwan Choi, Gwang Ha Kim, Jae Hak Kim, Yoon Ju Jo, Joon Seong Lee, HyoJin Park

Research output: Contribution to journalArticle

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Abstract

Colonic pseudo-obstruction (CPO) is defined as marked colonic distension in the absence of mechanical obstruction. We aimed to investigate the clinical characteristics of CPO and the factors associated with the response to medical treatment by using a multicenter database in Korea. CPO was diagnosed as colonic dilatation without mechanical obstruction by using radiologic and/or endoscopic examinations. Acute CPO occurring in the postoperative period in surgical patients or as a response to an acute illness was excluded. CPO cases were identified in 15 tertiary referral hospitals between 2000 and 2011. The patients' data were retrospectively reviewed and analyzed. In total, 104 patients (53 men; mean age at diagnosis, 47 yr) were identified. Seventy-seven of 104 patients (74%) showed a transition zone on abdominal computed tomography. Sixty of 104 patients (58%) showed poor responses to medical treatment and underwent surgery at the mean follow-up of 7.4 months (0.5-61 months). Younger age at the time of diagnosis, abdominal distension as a chief complaint, and greater cecal diameter were independently associated with the poor responses to medical treatment. These may be risk factors for a poor response to medical treatment.

Original languageEnglish
Pages (from-to)699-703
Number of pages5
JournalJournal of Korean medical science
Volume29
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Colonic Pseudo-Obstruction
Korea
Databases
Therapeutics
Postoperative Period
Tertiary Care Centers
Dilatation
Tomography

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Kwang Jae ; Jung, Kee Wook ; Myung, Seung Jae ; Kim, Hyun Jin ; Kim, Na Young ; Yoon, Young Hoon ; Sohn, Chong Il ; Shin, Jung Eun ; Cho, Yu Kyung ; Hong, Soo Jin ; Lee, Tae Hee ; Park, Kyung Sik ; Jung, Hye Kyung ; Choi, Chang Hwan ; Kim, Gwang Ha ; Kim, Jae Hak ; Jo, Yoon Ju ; Lee, Joon Seong ; Park, HyoJin. / The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response : A study based on a multicenter database in Korea. In: Journal of Korean medical science. 2014 ; Vol. 29, No. 5. pp. 699-703.
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abstract = "Colonic pseudo-obstruction (CPO) is defined as marked colonic distension in the absence of mechanical obstruction. We aimed to investigate the clinical characteristics of CPO and the factors associated with the response to medical treatment by using a multicenter database in Korea. CPO was diagnosed as colonic dilatation without mechanical obstruction by using radiologic and/or endoscopic examinations. Acute CPO occurring in the postoperative period in surgical patients or as a response to an acute illness was excluded. CPO cases were identified in 15 tertiary referral hospitals between 2000 and 2011. The patients' data were retrospectively reviewed and analyzed. In total, 104 patients (53 men; mean age at diagnosis, 47 yr) were identified. Seventy-seven of 104 patients (74{\%}) showed a transition zone on abdominal computed tomography. Sixty of 104 patients (58{\%}) showed poor responses to medical treatment and underwent surgery at the mean follow-up of 7.4 months (0.5-61 months). Younger age at the time of diagnosis, abdominal distension as a chief complaint, and greater cecal diameter were independently associated with the poor responses to medical treatment. These may be risk factors for a poor response to medical treatment.",
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Lee, KJ, Jung, KW, Myung, SJ, Kim, HJ, Kim, NY, Yoon, YH, Sohn, CI, Shin, JE, Cho, YK, Hong, SJ, Lee, TH, Park, KS, Jung, HK, Choi, CH, Kim, GH, Kim, JH, Jo, YJ, Lee, JS & Park, H 2014, 'The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response: A study based on a multicenter database in Korea', Journal of Korean medical science, vol. 29, no. 5, pp. 699-703. https://doi.org/10.3346/jkms.2014.29.5.699

The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response : A study based on a multicenter database in Korea. / Lee, Kwang Jae; Jung, Kee Wook; Myung, Seung Jae; Kim, Hyun Jin; Kim, Na Young; Yoon, Young Hoon; Sohn, Chong Il; Shin, Jung Eun; Cho, Yu Kyung; Hong, Soo Jin; Lee, Tae Hee; Park, Kyung Sik; Jung, Hye Kyung; Choi, Chang Hwan; Kim, Gwang Ha; Kim, Jae Hak; Jo, Yoon Ju; Lee, Joon Seong; Park, HyoJin.

In: Journal of Korean medical science, Vol. 29, No. 5, 01.01.2014, p. 699-703.

Research output: Contribution to journalArticle

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T1 - The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response

T2 - A study based on a multicenter database in Korea

AU - Lee, Kwang Jae

AU - Jung, Kee Wook

AU - Myung, Seung Jae

AU - Kim, Hyun Jin

AU - Kim, Na Young

AU - Yoon, Young Hoon

AU - Sohn, Chong Il

AU - Shin, Jung Eun

AU - Cho, Yu Kyung

AU - Hong, Soo Jin

AU - Lee, Tae Hee

AU - Park, Kyung Sik

AU - Jung, Hye Kyung

AU - Choi, Chang Hwan

AU - Kim, Gwang Ha

AU - Kim, Jae Hak

AU - Jo, Yoon Ju

AU - Lee, Joon Seong

AU - Park, HyoJin

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Y1 - 2014/1/1

N2 - Colonic pseudo-obstruction (CPO) is defined as marked colonic distension in the absence of mechanical obstruction. We aimed to investigate the clinical characteristics of CPO and the factors associated with the response to medical treatment by using a multicenter database in Korea. CPO was diagnosed as colonic dilatation without mechanical obstruction by using radiologic and/or endoscopic examinations. Acute CPO occurring in the postoperative period in surgical patients or as a response to an acute illness was excluded. CPO cases were identified in 15 tertiary referral hospitals between 2000 and 2011. The patients' data were retrospectively reviewed and analyzed. In total, 104 patients (53 men; mean age at diagnosis, 47 yr) were identified. Seventy-seven of 104 patients (74%) showed a transition zone on abdominal computed tomography. Sixty of 104 patients (58%) showed poor responses to medical treatment and underwent surgery at the mean follow-up of 7.4 months (0.5-61 months). Younger age at the time of diagnosis, abdominal distension as a chief complaint, and greater cecal diameter were independently associated with the poor responses to medical treatment. These may be risk factors for a poor response to medical treatment.

AB - Colonic pseudo-obstruction (CPO) is defined as marked colonic distension in the absence of mechanical obstruction. We aimed to investigate the clinical characteristics of CPO and the factors associated with the response to medical treatment by using a multicenter database in Korea. CPO was diagnosed as colonic dilatation without mechanical obstruction by using radiologic and/or endoscopic examinations. Acute CPO occurring in the postoperative period in surgical patients or as a response to an acute illness was excluded. CPO cases were identified in 15 tertiary referral hospitals between 2000 and 2011. The patients' data were retrospectively reviewed and analyzed. In total, 104 patients (53 men; mean age at diagnosis, 47 yr) were identified. Seventy-seven of 104 patients (74%) showed a transition zone on abdominal computed tomography. Sixty of 104 patients (58%) showed poor responses to medical treatment and underwent surgery at the mean follow-up of 7.4 months (0.5-61 months). Younger age at the time of diagnosis, abdominal distension as a chief complaint, and greater cecal diameter were independently associated with the poor responses to medical treatment. These may be risk factors for a poor response to medical treatment.

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