The clinical characteristics of patients with free perforation in Korean Crohn's disease: Results from the CONNECT study

Young Seok Doh, You Sun Kim, Song I. Bae, Jong Pil Im, Jae Hee Cheon, Byong Duk Ye, Ji Won Kim, Young Sook Park, Ji Hyun Lee, Young Ho Kim, Joo Sung Kim, Dong Soo Han, Won Ho Kim

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6 Citations (Scopus)

Abstract

Background: Free perforation is the most severe and debilitating complication associated with Crohn's disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free perforation among Korean patients with CD. Methods: The CrOhn's disease cliNical NEtwork and CohorT (CONNECT) study was conducted nationwide in Korea, and patients who were diagnosed with CD between 1982 and 2008 were included in this retrospective study. We investigated the incidence of free perforation among these patients and their clinical characteristics. Results: A total of 1346 patients were analyzed and 88 patients (6.5%) were identified with free perforation in CD. The mean age of the free perforation group was 31.8±13.0years, which was significantly higher than that of the non-perforated group (27.5±12.1years) (p=0.004). Free perforation was the presenting sign of CD in 46 patients (52%). Of the 94 perforations that were present in 88 patients, 81 involved the ileum. Multivariate logistic regression analysis determined that free perforation was significantly associated with being aged≥30years at diagnosis (OR 2.082, p=0.002) and bowel strictures (OR 1.982, p=0.004). The mortality rate in the free perforation group was significantly higher (4.5%) than that in the non-perforated group (0.6%) (p<0.001). Conclusion: The incidence of free perforation in Korean patients with CD was 6.5%. Being aged≥30years at CD diagnosis and bowel strictures were significant risk factors associated with free perforation.

Original languageEnglish
Article number31
JournalBMC Gastroenterology
Volume15
Issue number1
DOIs
Publication statusPublished - 2015 Mar 18

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Crohn Disease
Cohort Studies
Incidence
Pathologic Constriction
Clinical Studies
Korea
Ileum
Emergencies
Retrospective Studies
Logistic Models
Regression Analysis
Mortality

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Doh, Young Seok ; Kim, You Sun ; Bae, Song I. ; Im, Jong Pil ; Cheon, Jae Hee ; Ye, Byong Duk ; Kim, Ji Won ; Park, Young Sook ; Lee, Ji Hyun ; Kim, Young Ho ; Kim, Joo Sung ; Han, Dong Soo ; Kim, Won Ho. / The clinical characteristics of patients with free perforation in Korean Crohn's disease : Results from the CONNECT study. In: BMC Gastroenterology. 2015 ; Vol. 15, No. 1.
@article{4c03174191554786ac3b18abaaa56154,
title = "The clinical characteristics of patients with free perforation in Korean Crohn's disease: Results from the CONNECT study",
abstract = "Background: Free perforation is the most severe and debilitating complication associated with Crohn's disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free perforation among Korean patients with CD. Methods: The CrOhn's disease cliNical NEtwork and CohorT (CONNECT) study was conducted nationwide in Korea, and patients who were diagnosed with CD between 1982 and 2008 were included in this retrospective study. We investigated the incidence of free perforation among these patients and their clinical characteristics. Results: A total of 1346 patients were analyzed and 88 patients (6.5{\%}) were identified with free perforation in CD. The mean age of the free perforation group was 31.8±13.0years, which was significantly higher than that of the non-perforated group (27.5±12.1years) (p=0.004). Free perforation was the presenting sign of CD in 46 patients (52{\%}). Of the 94 perforations that were present in 88 patients, 81 involved the ileum. Multivariate logistic regression analysis determined that free perforation was significantly associated with being aged≥30years at diagnosis (OR 2.082, p=0.002) and bowel strictures (OR 1.982, p=0.004). The mortality rate in the free perforation group was significantly higher (4.5{\%}) than that in the non-perforated group (0.6{\%}) (p<0.001). Conclusion: The incidence of free perforation in Korean patients with CD was 6.5{\%}. Being aged≥30years at CD diagnosis and bowel strictures were significant risk factors associated with free perforation.",
author = "Doh, {Young Seok} and Kim, {You Sun} and Bae, {Song I.} and Im, {Jong Pil} and Cheon, {Jae Hee} and Ye, {Byong Duk} and Kim, {Ji Won} and Park, {Young Sook} and Lee, {Ji Hyun} and Kim, {Young Ho} and Kim, {Joo Sung} and Han, {Dong Soo} and Kim, {Won Ho}",
year = "2015",
month = "3",
day = "18",
doi = "10.1186/s12876-015-0262-x",
language = "English",
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Doh, YS, Kim, YS, Bae, SI, Im, JP, Cheon, JH, Ye, BD, Kim, JW, Park, YS, Lee, JH, Kim, YH, Kim, JS, Han, DS & Kim, WH 2015, 'The clinical characteristics of patients with free perforation in Korean Crohn's disease: Results from the CONNECT study', BMC Gastroenterology, vol. 15, no. 1, 31. https://doi.org/10.1186/s12876-015-0262-x

The clinical characteristics of patients with free perforation in Korean Crohn's disease : Results from the CONNECT study. / Doh, Young Seok; Kim, You Sun; Bae, Song I.; Im, Jong Pil; Cheon, Jae Hee; Ye, Byong Duk; Kim, Ji Won; Park, Young Sook; Lee, Ji Hyun; Kim, Young Ho; Kim, Joo Sung; Han, Dong Soo; Kim, Won Ho.

In: BMC Gastroenterology, Vol. 15, No. 1, 31, 18.03.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The clinical characteristics of patients with free perforation in Korean Crohn's disease

T2 - Results from the CONNECT study

AU - Doh, Young Seok

AU - Kim, You Sun

AU - Bae, Song I.

AU - Im, Jong Pil

AU - Cheon, Jae Hee

AU - Ye, Byong Duk

AU - Kim, Ji Won

AU - Park, Young Sook

AU - Lee, Ji Hyun

AU - Kim, Young Ho

AU - Kim, Joo Sung

AU - Han, Dong Soo

AU - Kim, Won Ho

PY - 2015/3/18

Y1 - 2015/3/18

N2 - Background: Free perforation is the most severe and debilitating complication associated with Crohn's disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free perforation among Korean patients with CD. Methods: The CrOhn's disease cliNical NEtwork and CohorT (CONNECT) study was conducted nationwide in Korea, and patients who were diagnosed with CD between 1982 and 2008 were included in this retrospective study. We investigated the incidence of free perforation among these patients and their clinical characteristics. Results: A total of 1346 patients were analyzed and 88 patients (6.5%) were identified with free perforation in CD. The mean age of the free perforation group was 31.8±13.0years, which was significantly higher than that of the non-perforated group (27.5±12.1years) (p=0.004). Free perforation was the presenting sign of CD in 46 patients (52%). Of the 94 perforations that were present in 88 patients, 81 involved the ileum. Multivariate logistic regression analysis determined that free perforation was significantly associated with being aged≥30years at diagnosis (OR 2.082, p=0.002) and bowel strictures (OR 1.982, p=0.004). The mortality rate in the free perforation group was significantly higher (4.5%) than that in the non-perforated group (0.6%) (p<0.001). Conclusion: The incidence of free perforation in Korean patients with CD was 6.5%. Being aged≥30years at CD diagnosis and bowel strictures were significant risk factors associated with free perforation.

AB - Background: Free perforation is the most severe and debilitating complication associated with Crohn's disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free perforation among Korean patients with CD. Methods: The CrOhn's disease cliNical NEtwork and CohorT (CONNECT) study was conducted nationwide in Korea, and patients who were diagnosed with CD between 1982 and 2008 were included in this retrospective study. We investigated the incidence of free perforation among these patients and their clinical characteristics. Results: A total of 1346 patients were analyzed and 88 patients (6.5%) were identified with free perforation in CD. The mean age of the free perforation group was 31.8±13.0years, which was significantly higher than that of the non-perforated group (27.5±12.1years) (p=0.004). Free perforation was the presenting sign of CD in 46 patients (52%). Of the 94 perforations that were present in 88 patients, 81 involved the ileum. Multivariate logistic regression analysis determined that free perforation was significantly associated with being aged≥30years at diagnosis (OR 2.082, p=0.002) and bowel strictures (OR 1.982, p=0.004). The mortality rate in the free perforation group was significantly higher (4.5%) than that in the non-perforated group (0.6%) (p<0.001). Conclusion: The incidence of free perforation in Korean patients with CD was 6.5%. Being aged≥30years at CD diagnosis and bowel strictures were significant risk factors associated with free perforation.

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U2 - 10.1186/s12876-015-0262-x

DO - 10.1186/s12876-015-0262-x

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