The clinical effect of locally delivered minocycline in association with flap surgery for the treatment of chronic severe periodontitis: A split-mouth design

Dong Yeol Jung, Jung Chul Park, Young Taek Kim, Je Young Yon, Gun Il Im, Byung Soo Kim, Seong Ho Choi, Kyoo Sung Cho, Chang Sung Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective The purpose of this study was to determine the effectiveness of adjunctive application of locally delivered minocycline ointment associated with flap surgery for the treatment of patients with chronic severe periodontitis. Material and Methods Twenty patients with chronic severe periodontitis were treated in a split-mouth study to either adjunctive application of locally delivered minocycline ointment in association with flap surgery (FM) or flap surgery only (FO); additional minocycline application was performed at 3 months post operation. Clinical evaluation of the plaque index, probing depth (PD), bleeding on probing (BOP), gingival recession, and clinical attachment level (CAL) was conducted at baseline and at 3 and 6 months after treatment. Results Clinical evaluations revealed that although both sites exhibited clinical improvement, there was a statistically significant reduction in PD (3.34 ± 0.03 mm) and BOP (78.01 ± 11.42%), and a significant gain of CAL (1.88 ± 0.21 mm) at the FM site compared with the FO site (reduction of PD and BOP: 2.62 ± 0.06 mm, 50.33 ± 15.01%, and gain of CAL: 1.55 ± 0.13 mm) at 6 months post operation (p < 0.05). Conclusion Adjunctive application of locally delivered minocycline may be beneficial to the surgical treatment protocol of chronic severe periodontitis.

Original languageEnglish
Pages (from-to)753-759
Number of pages7
JournalJournal of Clinical Periodontology
Volume39
Issue number8
DOIs
Publication statusPublished - 2012 Aug

All Science Journal Classification (ASJC) codes

  • Periodontics

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