The clinical effects of anorganic bovine-derived hydroxyapatite matrix(Abm)/cell binding peptide (P-15) in human periodontal defects

The purpose of this study was to evaluate the case performed only with flap operation and results compared after 6 months in cases grafted with freeze dried bone to see the clinical effect of periodontal tissue regeneration in periodontal intrabony pocket with ABM/P-15. We used thirty four 2-wall or 3-wall osseous defects in premolars and molars of chronic periodontitis patient that have more than 5mm pockets and more than 3mm in intrabony defect. 12 negative control group underwent flap procedure only, 11 positive control group received DFDBA graft with flap procedure, and 11 experimental group received ABM/P-15 graft with flap procedure. The results show that the use of ABM/P-15 in the treatment of periodontal intrabony defects can reduce loss of attachment and bone probing depth more than flap operation only. It suggests that ABM/P-15 may be an effective bone graft material for the regeneration of periodontal tissue in intrabony defects.