The clinical efficacy of a pure alginate formulation (Lamina G) for controlling symptoms in individuals with reflux symptoms: A randomized clinical study

Jie Hyun Kim, Yong Chan Lee, Eun Hye Kim, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Da Hyun Jung, Jae Jun Park, Young Hoon Youn, Hyojin Park

Research output: Contribution to journalArticle

Abstract

Background/Aims: Bicarbonate-containing alginate formulations are reported to be effective for controlling reflux symptoms. However, the efficacy of Lamina G alginate without gas production has not been reported. The aim is to evaluate the efficacy of a non-bicarbonate alginate in individuals with reflux symptoms without reflux esophagitis. Methods: Participants who had experienced heartburn or regurgitation for 7 consecutive days were randomized to one of the following treatment groups: proton pump inhibitors (PPI) plus alginate (combination) or PPI plus placebo (PPI only). In addition, as a reference group, patients received placebo plus alginate (alginate only). The primary endpoint compared the percentage of patients with complete resolution of symptoms for the final 7 days of the treatment. Secondary endpoints compared changes in symptom score, symptom-free days during the treatment period, the Reflux Disease Questionnaire, Patient Assessment of Upper Gastrointestinal Disorders (PAGI)Quality of Life and PAGI-Symptoms Severity Index scores, the investigator's assessment of symptoms, and incidence of adverse events. Results: Complete resolution of heartburn or regurgitation was not significantly different between the combination and PPI only groups (58.7% vs 57.5%, p=0.903). The secondary endpoints were not significantly different between the two groups. Complete resolution of heartburn or regurgitation, did not differ between the alginate only reference group and the PPI only group (75.0% vs 57.5%, p=0.146). Conclusions: The addition of non-bicarbonate alginate to PPI was no more effective than PPI alone in controlling reflux symptoms.

Original languageEnglish
Pages (from-to)642-648
Number of pages7
JournalGut and liver
Volume13
Issue number6
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'The clinical efficacy of a pure alginate formulation (Lamina G) for controlling symptoms in individuals with reflux symptoms: A randomized clinical study'. Together they form a unique fingerprint.

  • Cite this