The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor

Gwi Hyun Choi, Jae Keun Oh, Tae Yup Kim, Nam Kyu You, Hyo Sang Lee, Do Heum Yoon, Yoon Ha, Seong Yi, Dong Seok Kim, Joong Uhn Choi, Keung Nyun Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Primary spinal cord tumors (PSCTs) in pediatric patients are rare, with a reported overall incidence rate of 1-2.6 per one million children. We reviewed our experience of surgically treated 27 pediatric patients with PSCT and discussed the clinical features, radiological findings, surgical outcomes, and prognostic factors. Methods Between March 1999 and March 2010, a total of 27 pediatric patients with PSCT were surgically treated in a single institution. We retrospectively analyzed their data. Results There were 13 females and 14 males, and their ages ranged from 6 months to 19 years (mean age, 12.1 years). The most common presenting symptom was motor weakness, and the histologic type of the tumors were mainly schwannoma, astrocytoma, and ependymoma. The tumor was completely resected in 17 patients, subtotally resected in 7 patients, and partial resection or biopsy was performed in 3 patients. Adjuvant chemotherapy was performed in 9 patients, and radiotherapy in 12 patients, respectively. The average follow-up period was 33.5 months (1.17-129). Five patients experienced the progression of disease, and three of them expired. The mean time for disease progression was 19.0 months (4.5-48.7). Conclusions PSCT in pediatric patients can be surgically removed with an acceptable low surgical morbidity. Progression-free survival was found to be related to the grade of tumor and the extent of tumor resection. Early diagnosis and treatment anticipate good functional neurologic outcome.

Original languageEnglish
Pages (from-to)897-904
Number of pages8
JournalChild's Nervous System
Volume28
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

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Spinal Cord Neoplasms
Pediatrics
Disease Progression
Neoplasms
Ependymoma
Neurilemmoma
Astrocytoma
Adjuvant Chemotherapy
Nervous System
Disease-Free Survival
Early Diagnosis
Radiotherapy

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Choi, G. H., Oh, J. K., Kim, T. Y., You, N. K., Lee, H. S., Yoon, D. H., ... Kim, K. N. (2012). The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor. Child's Nervous System, 28(6), 897-904. https://doi.org/10.1007/s00381-012-1718-8
Choi, Gwi Hyun ; Oh, Jae Keun ; Kim, Tae Yup ; You, Nam Kyu ; Lee, Hyo Sang ; Yoon, Do Heum ; Ha, Yoon ; Yi, Seong ; Kim, Dong Seok ; Choi, Joong Uhn ; Kim, Keung Nyun. / The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor. In: Child's Nervous System. 2012 ; Vol. 28, No. 6. pp. 897-904.
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abstract = "Background: Primary spinal cord tumors (PSCTs) in pediatric patients are rare, with a reported overall incidence rate of 1-2.6 per one million children. We reviewed our experience of surgically treated 27 pediatric patients with PSCT and discussed the clinical features, radiological findings, surgical outcomes, and prognostic factors. Methods Between March 1999 and March 2010, a total of 27 pediatric patients with PSCT were surgically treated in a single institution. We retrospectively analyzed their data. Results There were 13 females and 14 males, and their ages ranged from 6 months to 19 years (mean age, 12.1 years). The most common presenting symptom was motor weakness, and the histologic type of the tumors were mainly schwannoma, astrocytoma, and ependymoma. The tumor was completely resected in 17 patients, subtotally resected in 7 patients, and partial resection or biopsy was performed in 3 patients. Adjuvant chemotherapy was performed in 9 patients, and radiotherapy in 12 patients, respectively. The average follow-up period was 33.5 months (1.17-129). Five patients experienced the progression of disease, and three of them expired. The mean time for disease progression was 19.0 months (4.5-48.7). Conclusions PSCT in pediatric patients can be surgically removed with an acceptable low surgical morbidity. Progression-free survival was found to be related to the grade of tumor and the extent of tumor resection. Early diagnosis and treatment anticipate good functional neurologic outcome.",
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Choi, GH, Oh, JK, Kim, TY, You, NK, Lee, HS, Yoon, DH, Ha, Y, Yi, S, Kim, DS, Choi, JU & Kim, KN 2012, 'The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor', Child's Nervous System, vol. 28, no. 6, pp. 897-904. https://doi.org/10.1007/s00381-012-1718-8

The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor. / Choi, Gwi Hyun; Oh, Jae Keun; Kim, Tae Yup; You, Nam Kyu; Lee, Hyo Sang; Yoon, Do Heum; Ha, Yoon; Yi, Seong; Kim, Dong Seok; Choi, Joong Uhn; Kim, Keung Nyun.

In: Child's Nervous System, Vol. 28, No. 6, 01.06.2012, p. 897-904.

Research output: Contribution to journalArticle

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T1 - The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor

AU - Choi, Gwi Hyun

AU - Oh, Jae Keun

AU - Kim, Tae Yup

AU - You, Nam Kyu

AU - Lee, Hyo Sang

AU - Yoon, Do Heum

AU - Ha, Yoon

AU - Yi, Seong

AU - Kim, Dong Seok

AU - Choi, Joong Uhn

AU - Kim, Keung Nyun

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Background: Primary spinal cord tumors (PSCTs) in pediatric patients are rare, with a reported overall incidence rate of 1-2.6 per one million children. We reviewed our experience of surgically treated 27 pediatric patients with PSCT and discussed the clinical features, radiological findings, surgical outcomes, and prognostic factors. Methods Between March 1999 and March 2010, a total of 27 pediatric patients with PSCT were surgically treated in a single institution. We retrospectively analyzed their data. Results There were 13 females and 14 males, and their ages ranged from 6 months to 19 years (mean age, 12.1 years). The most common presenting symptom was motor weakness, and the histologic type of the tumors were mainly schwannoma, astrocytoma, and ependymoma. The tumor was completely resected in 17 patients, subtotally resected in 7 patients, and partial resection or biopsy was performed in 3 patients. Adjuvant chemotherapy was performed in 9 patients, and radiotherapy in 12 patients, respectively. The average follow-up period was 33.5 months (1.17-129). Five patients experienced the progression of disease, and three of them expired. The mean time for disease progression was 19.0 months (4.5-48.7). Conclusions PSCT in pediatric patients can be surgically removed with an acceptable low surgical morbidity. Progression-free survival was found to be related to the grade of tumor and the extent of tumor resection. Early diagnosis and treatment anticipate good functional neurologic outcome.

AB - Background: Primary spinal cord tumors (PSCTs) in pediatric patients are rare, with a reported overall incidence rate of 1-2.6 per one million children. We reviewed our experience of surgically treated 27 pediatric patients with PSCT and discussed the clinical features, radiological findings, surgical outcomes, and prognostic factors. Methods Between March 1999 and March 2010, a total of 27 pediatric patients with PSCT were surgically treated in a single institution. We retrospectively analyzed their data. Results There were 13 females and 14 males, and their ages ranged from 6 months to 19 years (mean age, 12.1 years). The most common presenting symptom was motor weakness, and the histologic type of the tumors were mainly schwannoma, astrocytoma, and ependymoma. The tumor was completely resected in 17 patients, subtotally resected in 7 patients, and partial resection or biopsy was performed in 3 patients. Adjuvant chemotherapy was performed in 9 patients, and radiotherapy in 12 patients, respectively. The average follow-up period was 33.5 months (1.17-129). Five patients experienced the progression of disease, and three of them expired. The mean time for disease progression was 19.0 months (4.5-48.7). Conclusions PSCT in pediatric patients can be surgically removed with an acceptable low surgical morbidity. Progression-free survival was found to be related to the grade of tumor and the extent of tumor resection. Early diagnosis and treatment anticipate good functional neurologic outcome.

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