The clinical features of spinal leptomeningeal dissemination from malignant gliomas

Jung Sik Bae, Seung Ho Yang, Woan Soo Yoon, Seok Gu Kang, Yong Kil Hong, Sin Soo Jeun

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: The incidence of leptomeningeal dissemination from malignant glioma is rare, so the clinical features of this are not well documented yet. We attempted to determine the clinical features of leptomeningeal dissemination from malignant gliomas. Methods: We retrospectively analyzed 11 cases of leptomeningeal dissemination of malignant glioma, who were treated at our institution between 2006 and 2009. We investigated the clinical features of these patients by considering the following factors: tumor locations, the events of ventricular opening during surgery and the cerebrospinal fluid (CSF) profiles, including the cytology. Results: The group was composed of 9 males and 2 females. The histological diagnosis of their initial intracranial tumors were 4 primary glioblastoma, 3 anaplastic astrocytoma, 1 anaplastic oligoastrocytoma, 2 ganglioglioma and 1 pleomorphic xanthoastrocyotma with anaplastic features. The mean age of the patients at the time of the initial presentation was 42.8±10.3 years. The mean time between surgery and the diagnosis of spinal dissemination was 12.3±7.9 (3-28) months. The mean overall survival after dissemination was 2.7±1.3 months. All our patients revealed a history of surgical opening of the ventricles. Elevated protein in the CSF was reported for eight patients who had their CSF profiles checked. Conclusion: We propose that in the malignant gliomas, the surgical opening of ventricles can cause the spinal leptomeningeal dissemination and the elevated protein content of CSF may be a candidate marker of leptomeningeal dissemination.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalJournal of Korean Neurosurgical Society
Volume49
Issue number6
DOIs
Publication statusPublished - 2011 Jan 1

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Glioma
Cerebrospinal Fluid Proteins
Cerebrospinal Fluid
Ganglioglioma
Astrocytoma
Glioblastoma
Cell Biology
Neoplasms
Survival
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neuroscience(all)
  • Clinical Neurology

Cite this

Bae, Jung Sik ; Yang, Seung Ho ; Yoon, Woan Soo ; Kang, Seok Gu ; Hong, Yong Kil ; Jeun, Sin Soo. / The clinical features of spinal leptomeningeal dissemination from malignant gliomas. In: Journal of Korean Neurosurgical Society. 2011 ; Vol. 49, No. 6. pp. 334-338.
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The clinical features of spinal leptomeningeal dissemination from malignant gliomas. / Bae, Jung Sik; Yang, Seung Ho; Yoon, Woan Soo; Kang, Seok Gu; Hong, Yong Kil; Jeun, Sin Soo.

In: Journal of Korean Neurosurgical Society, Vol. 49, No. 6, 01.01.2011, p. 334-338.

Research output: Contribution to journalArticle

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T1 - The clinical features of spinal leptomeningeal dissemination from malignant gliomas

AU - Bae, Jung Sik

AU - Yang, Seung Ho

AU - Yoon, Woan Soo

AU - Kang, Seok Gu

AU - Hong, Yong Kil

AU - Jeun, Sin Soo

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N2 - Objective: The incidence of leptomeningeal dissemination from malignant glioma is rare, so the clinical features of this are not well documented yet. We attempted to determine the clinical features of leptomeningeal dissemination from malignant gliomas. Methods: We retrospectively analyzed 11 cases of leptomeningeal dissemination of malignant glioma, who were treated at our institution between 2006 and 2009. We investigated the clinical features of these patients by considering the following factors: tumor locations, the events of ventricular opening during surgery and the cerebrospinal fluid (CSF) profiles, including the cytology. Results: The group was composed of 9 males and 2 females. The histological diagnosis of their initial intracranial tumors were 4 primary glioblastoma, 3 anaplastic astrocytoma, 1 anaplastic oligoastrocytoma, 2 ganglioglioma and 1 pleomorphic xanthoastrocyotma with anaplastic features. The mean age of the patients at the time of the initial presentation was 42.8±10.3 years. The mean time between surgery and the diagnosis of spinal dissemination was 12.3±7.9 (3-28) months. The mean overall survival after dissemination was 2.7±1.3 months. All our patients revealed a history of surgical opening of the ventricles. Elevated protein in the CSF was reported for eight patients who had their CSF profiles checked. Conclusion: We propose that in the malignant gliomas, the surgical opening of ventricles can cause the spinal leptomeningeal dissemination and the elevated protein content of CSF may be a candidate marker of leptomeningeal dissemination.

AB - Objective: The incidence of leptomeningeal dissemination from malignant glioma is rare, so the clinical features of this are not well documented yet. We attempted to determine the clinical features of leptomeningeal dissemination from malignant gliomas. Methods: We retrospectively analyzed 11 cases of leptomeningeal dissemination of malignant glioma, who were treated at our institution between 2006 and 2009. We investigated the clinical features of these patients by considering the following factors: tumor locations, the events of ventricular opening during surgery and the cerebrospinal fluid (CSF) profiles, including the cytology. Results: The group was composed of 9 males and 2 females. The histological diagnosis of their initial intracranial tumors were 4 primary glioblastoma, 3 anaplastic astrocytoma, 1 anaplastic oligoastrocytoma, 2 ganglioglioma and 1 pleomorphic xanthoastrocyotma with anaplastic features. The mean age of the patients at the time of the initial presentation was 42.8±10.3 years. The mean time between surgery and the diagnosis of spinal dissemination was 12.3±7.9 (3-28) months. The mean overall survival after dissemination was 2.7±1.3 months. All our patients revealed a history of surgical opening of the ventricles. Elevated protein in the CSF was reported for eight patients who had their CSF profiles checked. Conclusion: We propose that in the malignant gliomas, the surgical opening of ventricles can cause the spinal leptomeningeal dissemination and the elevated protein content of CSF may be a candidate marker of leptomeningeal dissemination.

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