The clinical report of 1,078 cases of hepatocellular carcinomas

National Cancer Center experience

JaeHee Cheon, Joong Won Park, Kyung Woo Park, Young Il Kim, Sung Hoon Kim, Woo Jin Lee, Hong Suk Park, Sang Jae Park, Eun Kyoung Hong, Chang Min Kim

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Abstract

BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is the third leading cause of cancer and the 5 year survival rate is 9.6% in Korea. To develop a strategy for surveillance and treatments, we studied the recent clinical characteristics of HCC diagnosed at single institution in Korea, where is in an endemic area of chronic hepatitis B. METHODS: One thousand and seventy eight patients with HCC who visited the National Cancer Center between June 2001 and December 2003 were retrospectively studied. RESULTS: The male/female ratio was 4.5:1. The mean age of the patients was 56.3 years. 74.2% of patient had hepatitis B virus (HBV) infections, 8.6% had hepatitis C virus (HCV) infections, 6.9% of the patients abused alcohol and 10.3% of the patients had non-B non-C considered as the etiologic factors of their HCC. Only 10.0% of patients had a tumor sized 2 cm or less and 53.3% of patients had a large tumor over 5 cm in diameter. 33.2% of patients had a single tumor. At the time of diagnosis, the modified UICC staging was as follows: 6.5%, 20.1%, 30.9%, 25.2% and 17.3% in stages I, II, III, IVa and IVb, respectively. The initial treatment performed was transcatheter arterial chemoembolization (48.2%), radiofrequency ablation (1.5%), hepatic resection (11.2%), systemic chemotherapy (7.5%), radiotherapy (2.1%), and conservative medical treatments (29.5%). The mean number of treatments was 1.65. The response rates to the initial treatments were 27.9% (complete response), 23.6% (partial response), 7.5% (minimal response), 14.2% (stable disease), and 30.4% (progressive disease). CONCLUSIONS: HBV infection is a major etiologic factor for Korean HCC patients. Most cases are still in advanced stages and these cases responded poorly to any treatments. The national surveillance program and its guideline for HCC are expected to improve the survival of HCC patients.

Original languageEnglish
Pages (from-to)288-297
Number of pages10
JournalThe Korean journal of hepatology
Volume10
Issue number4
Publication statusPublished - 2004 Jan 1

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Hepatocellular Carcinoma
Neoplasms
Virus Diseases
Korea
Hepatitis B virus
Therapeutics
Chronic Hepatitis B
Hepacivirus
Radiotherapy
Survival Rate
Alcohols
Guidelines
Drug Therapy
Survival
Liver

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cheon, J., Park, J. W., Park, K. W., Kim, Y. I., Kim, S. H., Lee, W. J., ... Kim, C. M. (2004). The clinical report of 1,078 cases of hepatocellular carcinomas: National Cancer Center experience. The Korean journal of hepatology, 10(4), 288-297.
Cheon, JaeHee ; Park, Joong Won ; Park, Kyung Woo ; Kim, Young Il ; Kim, Sung Hoon ; Lee, Woo Jin ; Park, Hong Suk ; Park, Sang Jae ; Hong, Eun Kyoung ; Kim, Chang Min. / The clinical report of 1,078 cases of hepatocellular carcinomas : National Cancer Center experience. In: The Korean journal of hepatology. 2004 ; Vol. 10, No. 4. pp. 288-297.
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title = "The clinical report of 1,078 cases of hepatocellular carcinomas: National Cancer Center experience",
abstract = "BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is the third leading cause of cancer and the 5 year survival rate is 9.6{\%} in Korea. To develop a strategy for surveillance and treatments, we studied the recent clinical characteristics of HCC diagnosed at single institution in Korea, where is in an endemic area of chronic hepatitis B. METHODS: One thousand and seventy eight patients with HCC who visited the National Cancer Center between June 2001 and December 2003 were retrospectively studied. RESULTS: The male/female ratio was 4.5:1. The mean age of the patients was 56.3 years. 74.2{\%} of patient had hepatitis B virus (HBV) infections, 8.6{\%} had hepatitis C virus (HCV) infections, 6.9{\%} of the patients abused alcohol and 10.3{\%} of the patients had non-B non-C considered as the etiologic factors of their HCC. Only 10.0{\%} of patients had a tumor sized 2 cm or less and 53.3{\%} of patients had a large tumor over 5 cm in diameter. 33.2{\%} of patients had a single tumor. At the time of diagnosis, the modified UICC staging was as follows: 6.5{\%}, 20.1{\%}, 30.9{\%}, 25.2{\%} and 17.3{\%} in stages I, II, III, IVa and IVb, respectively. The initial treatment performed was transcatheter arterial chemoembolization (48.2{\%}), radiofrequency ablation (1.5{\%}), hepatic resection (11.2{\%}), systemic chemotherapy (7.5{\%}), radiotherapy (2.1{\%}), and conservative medical treatments (29.5{\%}). The mean number of treatments was 1.65. The response rates to the initial treatments were 27.9{\%} (complete response), 23.6{\%} (partial response), 7.5{\%} (minimal response), 14.2{\%} (stable disease), and 30.4{\%} (progressive disease). CONCLUSIONS: HBV infection is a major etiologic factor for Korean HCC patients. Most cases are still in advanced stages and these cases responded poorly to any treatments. The national surveillance program and its guideline for HCC are expected to improve the survival of HCC patients.",
author = "JaeHee Cheon and Park, {Joong Won} and Park, {Kyung Woo} and Kim, {Young Il} and Kim, {Sung Hoon} and Lee, {Woo Jin} and Park, {Hong Suk} and Park, {Sang Jae} and Hong, {Eun Kyoung} and Kim, {Chang Min}",
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Cheon, J, Park, JW, Park, KW, Kim, YI, Kim, SH, Lee, WJ, Park, HS, Park, SJ, Hong, EK & Kim, CM 2004, 'The clinical report of 1,078 cases of hepatocellular carcinomas: National Cancer Center experience', The Korean journal of hepatology, vol. 10, no. 4, pp. 288-297.

The clinical report of 1,078 cases of hepatocellular carcinomas : National Cancer Center experience. / Cheon, JaeHee; Park, Joong Won; Park, Kyung Woo; Kim, Young Il; Kim, Sung Hoon; Lee, Woo Jin; Park, Hong Suk; Park, Sang Jae; Hong, Eun Kyoung; Kim, Chang Min.

In: The Korean journal of hepatology, Vol. 10, No. 4, 01.01.2004, p. 288-297.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The clinical report of 1,078 cases of hepatocellular carcinomas

T2 - National Cancer Center experience

AU - Cheon, JaeHee

AU - Park, Joong Won

AU - Park, Kyung Woo

AU - Kim, Young Il

AU - Kim, Sung Hoon

AU - Lee, Woo Jin

AU - Park, Hong Suk

AU - Park, Sang Jae

AU - Hong, Eun Kyoung

AU - Kim, Chang Min

PY - 2004/1/1

Y1 - 2004/1/1

N2 - BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is the third leading cause of cancer and the 5 year survival rate is 9.6% in Korea. To develop a strategy for surveillance and treatments, we studied the recent clinical characteristics of HCC diagnosed at single institution in Korea, where is in an endemic area of chronic hepatitis B. METHODS: One thousand and seventy eight patients with HCC who visited the National Cancer Center between June 2001 and December 2003 were retrospectively studied. RESULTS: The male/female ratio was 4.5:1. The mean age of the patients was 56.3 years. 74.2% of patient had hepatitis B virus (HBV) infections, 8.6% had hepatitis C virus (HCV) infections, 6.9% of the patients abused alcohol and 10.3% of the patients had non-B non-C considered as the etiologic factors of their HCC. Only 10.0% of patients had a tumor sized 2 cm or less and 53.3% of patients had a large tumor over 5 cm in diameter. 33.2% of patients had a single tumor. At the time of diagnosis, the modified UICC staging was as follows: 6.5%, 20.1%, 30.9%, 25.2% and 17.3% in stages I, II, III, IVa and IVb, respectively. The initial treatment performed was transcatheter arterial chemoembolization (48.2%), radiofrequency ablation (1.5%), hepatic resection (11.2%), systemic chemotherapy (7.5%), radiotherapy (2.1%), and conservative medical treatments (29.5%). The mean number of treatments was 1.65. The response rates to the initial treatments were 27.9% (complete response), 23.6% (partial response), 7.5% (minimal response), 14.2% (stable disease), and 30.4% (progressive disease). CONCLUSIONS: HBV infection is a major etiologic factor for Korean HCC patients. Most cases are still in advanced stages and these cases responded poorly to any treatments. The national surveillance program and its guideline for HCC are expected to improve the survival of HCC patients.

AB - BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is the third leading cause of cancer and the 5 year survival rate is 9.6% in Korea. To develop a strategy for surveillance and treatments, we studied the recent clinical characteristics of HCC diagnosed at single institution in Korea, where is in an endemic area of chronic hepatitis B. METHODS: One thousand and seventy eight patients with HCC who visited the National Cancer Center between June 2001 and December 2003 were retrospectively studied. RESULTS: The male/female ratio was 4.5:1. The mean age of the patients was 56.3 years. 74.2% of patient had hepatitis B virus (HBV) infections, 8.6% had hepatitis C virus (HCV) infections, 6.9% of the patients abused alcohol and 10.3% of the patients had non-B non-C considered as the etiologic factors of their HCC. Only 10.0% of patients had a tumor sized 2 cm or less and 53.3% of patients had a large tumor over 5 cm in diameter. 33.2% of patients had a single tumor. At the time of diagnosis, the modified UICC staging was as follows: 6.5%, 20.1%, 30.9%, 25.2% and 17.3% in stages I, II, III, IVa and IVb, respectively. The initial treatment performed was transcatheter arterial chemoembolization (48.2%), radiofrequency ablation (1.5%), hepatic resection (11.2%), systemic chemotherapy (7.5%), radiotherapy (2.1%), and conservative medical treatments (29.5%). The mean number of treatments was 1.65. The response rates to the initial treatments were 27.9% (complete response), 23.6% (partial response), 7.5% (minimal response), 14.2% (stable disease), and 30.4% (progressive disease). CONCLUSIONS: HBV infection is a major etiologic factor for Korean HCC patients. Most cases are still in advanced stages and these cases responded poorly to any treatments. The national surveillance program and its guideline for HCC are expected to improve the survival of HCC patients.

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