The clinical significance of accompanying NME on preoperative MR imaging in breast cancer patients

Hye Mi Gweon, Jeong Joon, Eun Ju Son, Ji Hyun Youk, Jeong Ah Kim, Kyung Hee Ko

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the significance of accompanying NME in invasive ductal carcinoma (IDC) on preoperative MR imaging and assess the factors affecting the significance. Methods: Between January 2015 and February 2016, 163 consecutive patients with IDC who underwent preoperative MR imaging and subsequent surgery were enrolled and reviewed. Index cancer mass size and total extent with accompanying NME on MR images was measured and compared with pathologic size. Positive NME was defined as pathological result of IDC or DCIS. To identify affecting factors associated with frequency of accompanying NME on MR and positive pathologic result, clinicopathologic features were compared between breast cancers with NME and without NME, and between breast cancers with positive NME and negative NME using the Student t-test or Chi-square test. Results: Of the 163 invasive breast cancers, 123(75.5%) cancers presented as only mass feature and 40(24.5%) cancers had accompanying NME around the index mass. Of the 40 accompanying NME, 22 (55%) had positive pathologic results and 18 (45%) had negative results. The HER2 positive status was significantly associated with positive pathologic results of accompanying NME (P = .016). Conclusion: Accompanying NME on preoperative MR imaging showed malignant pathologic results in 55%. The HER2 positive IDC was more frequently accompanied by malignant NME.

Original languageEnglish
Article numbere0178445
JournalPLoS One
Volume12
Issue number5
DOIs
Publication statusPublished - 2017 May 1

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Ductal Carcinoma
breast neoplasms
carcinoma
image analysis
Breast Neoplasms
Imaging techniques
neoplasms
Neoplasms
Surgery
Carcinoma, Intraductal, Noninfiltrating
Chi-Square Distribution
Students
surgery
methodology

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Gweon, Hye Mi ; Joon, Jeong ; Son, Eun Ju ; Youk, Ji Hyun ; Kim, Jeong Ah ; Ko, Kyung Hee. / The clinical significance of accompanying NME on preoperative MR imaging in breast cancer patients. In: PLoS One. 2017 ; Vol. 12, No. 5.
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abstract = "Purpose: To investigate the significance of accompanying NME in invasive ductal carcinoma (IDC) on preoperative MR imaging and assess the factors affecting the significance. Methods: Between January 2015 and February 2016, 163 consecutive patients with IDC who underwent preoperative MR imaging and subsequent surgery were enrolled and reviewed. Index cancer mass size and total extent with accompanying NME on MR images was measured and compared with pathologic size. Positive NME was defined as pathological result of IDC or DCIS. To identify affecting factors associated with frequency of accompanying NME on MR and positive pathologic result, clinicopathologic features were compared between breast cancers with NME and without NME, and between breast cancers with positive NME and negative NME using the Student t-test or Chi-square test. Results: Of the 163 invasive breast cancers, 123(75.5{\%}) cancers presented as only mass feature and 40(24.5{\%}) cancers had accompanying NME around the index mass. Of the 40 accompanying NME, 22 (55{\%}) had positive pathologic results and 18 (45{\%}) had negative results. The HER2 positive status was significantly associated with positive pathologic results of accompanying NME (P = .016). Conclusion: Accompanying NME on preoperative MR imaging showed malignant pathologic results in 55{\%}. The HER2 positive IDC was more frequently accompanied by malignant NME.",
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The clinical significance of accompanying NME on preoperative MR imaging in breast cancer patients. / Gweon, Hye Mi; Joon, Jeong; Son, Eun Ju; Youk, Ji Hyun; Kim, Jeong Ah; Ko, Kyung Hee.

In: PLoS One, Vol. 12, No. 5, e0178445, 01.05.2017.

Research output: Contribution to journalArticle

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