The clinicopathologic features of molecular apocrine breast cancer

Yoon Jin Cha, Woo Hee Jung, Ja Seung Koo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: To elucidate the clinicopathologic features and their implications on the immunohistochemistry in cases of molecular apocrine breast cancer (MABC). Methods: Immunohistochemical (IHC) staining for estrogen receptor (ER), human epidermal growth factor receptor 2 (HER-2), cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), androgen receptor (AR), gammaglutamyltrasferase 1 (GGT1) and Ki-67 was performed on tissue microarray breast cancer samples from 204 patients. Phenotypes of breast cancer were divided based on the IHC status of ER, AR and GGT1 into the following: luminal type, ER positive and AR and/or GGT1 positive; basal type, ER, AR, and GGT1 negative; non-basal type, ER positive and AR and GGT1 negative; and MABC type, ER negative and AR and/or GGT1 positive. Results: In our series of patients (n=204), there were 26 cases of MABC. Besides, there were 18, 60, and 100 cases of luminal type, basal type and non-basal type, respectively. The MABC demonstrated apocrine histology and a higher prevalence of HER-2 positivity than other phenotypes. With the basal type, the MABC manifested a more frequent expression of CK5/6 and EGFR and a higher Ki-67 index than other phenotypes (p<0.001). There were no significant differences in patient prognosis between the phenotypes of breast cancer. Conclusions: MABC are distinguishable from other phenotypes based on the apocrine histology and a higher expression rate of HER-2.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalKorean Journal of Pathology
Volume46
Issue number2
DOIs
Publication statusPublished - 2012 Jul 9

Fingerprint

Androgen Receptors
Breast Neoplasms
Estrogen Receptors
Phenotype
Epidermal Growth Factor Receptor
Histology
Keratin-6
Keratin-5
Immunohistochemistry
Staining and Labeling
human ERBB2 protein

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Cha, Yoon Jin ; Jung, Woo Hee ; Koo, Ja Seung. / The clinicopathologic features of molecular apocrine breast cancer. In: Korean Journal of Pathology. 2012 ; Vol. 46, No. 2. pp. 169-176.
@article{55f2ad8c5fca40e7ab2fa557eb4b585c,
title = "The clinicopathologic features of molecular apocrine breast cancer",
abstract = "Background: To elucidate the clinicopathologic features and their implications on the immunohistochemistry in cases of molecular apocrine breast cancer (MABC). Methods: Immunohistochemical (IHC) staining for estrogen receptor (ER), human epidermal growth factor receptor 2 (HER-2), cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), androgen receptor (AR), gammaglutamyltrasferase 1 (GGT1) and Ki-67 was performed on tissue microarray breast cancer samples from 204 patients. Phenotypes of breast cancer were divided based on the IHC status of ER, AR and GGT1 into the following: luminal type, ER positive and AR and/or GGT1 positive; basal type, ER, AR, and GGT1 negative; non-basal type, ER positive and AR and GGT1 negative; and MABC type, ER negative and AR and/or GGT1 positive. Results: In our series of patients (n=204), there were 26 cases of MABC. Besides, there were 18, 60, and 100 cases of luminal type, basal type and non-basal type, respectively. The MABC demonstrated apocrine histology and a higher prevalence of HER-2 positivity than other phenotypes. With the basal type, the MABC manifested a more frequent expression of CK5/6 and EGFR and a higher Ki-67 index than other phenotypes (p<0.001). There were no significant differences in patient prognosis between the phenotypes of breast cancer. Conclusions: MABC are distinguishable from other phenotypes based on the apocrine histology and a higher expression rate of HER-2.",
author = "Cha, {Yoon Jin} and Jung, {Woo Hee} and Koo, {Ja Seung}",
year = "2012",
month = "7",
day = "9",
doi = "10.4132/KoreanJPathol.2012.46.2.169",
language = "English",
volume = "46",
pages = "169--176",
journal = "Journal of Pathology and Translational Medicine",
issn = "2383-7837",
publisher = "Korean Society of Pathologists",
number = "2",

}

The clinicopathologic features of molecular apocrine breast cancer. / Cha, Yoon Jin; Jung, Woo Hee; Koo, Ja Seung.

In: Korean Journal of Pathology, Vol. 46, No. 2, 09.07.2012, p. 169-176.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The clinicopathologic features of molecular apocrine breast cancer

AU - Cha, Yoon Jin

AU - Jung, Woo Hee

AU - Koo, Ja Seung

PY - 2012/7/9

Y1 - 2012/7/9

N2 - Background: To elucidate the clinicopathologic features and their implications on the immunohistochemistry in cases of molecular apocrine breast cancer (MABC). Methods: Immunohistochemical (IHC) staining for estrogen receptor (ER), human epidermal growth factor receptor 2 (HER-2), cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), androgen receptor (AR), gammaglutamyltrasferase 1 (GGT1) and Ki-67 was performed on tissue microarray breast cancer samples from 204 patients. Phenotypes of breast cancer were divided based on the IHC status of ER, AR and GGT1 into the following: luminal type, ER positive and AR and/or GGT1 positive; basal type, ER, AR, and GGT1 negative; non-basal type, ER positive and AR and GGT1 negative; and MABC type, ER negative and AR and/or GGT1 positive. Results: In our series of patients (n=204), there were 26 cases of MABC. Besides, there were 18, 60, and 100 cases of luminal type, basal type and non-basal type, respectively. The MABC demonstrated apocrine histology and a higher prevalence of HER-2 positivity than other phenotypes. With the basal type, the MABC manifested a more frequent expression of CK5/6 and EGFR and a higher Ki-67 index than other phenotypes (p<0.001). There were no significant differences in patient prognosis between the phenotypes of breast cancer. Conclusions: MABC are distinguishable from other phenotypes based on the apocrine histology and a higher expression rate of HER-2.

AB - Background: To elucidate the clinicopathologic features and their implications on the immunohistochemistry in cases of molecular apocrine breast cancer (MABC). Methods: Immunohistochemical (IHC) staining for estrogen receptor (ER), human epidermal growth factor receptor 2 (HER-2), cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), androgen receptor (AR), gammaglutamyltrasferase 1 (GGT1) and Ki-67 was performed on tissue microarray breast cancer samples from 204 patients. Phenotypes of breast cancer were divided based on the IHC status of ER, AR and GGT1 into the following: luminal type, ER positive and AR and/or GGT1 positive; basal type, ER, AR, and GGT1 negative; non-basal type, ER positive and AR and GGT1 negative; and MABC type, ER negative and AR and/or GGT1 positive. Results: In our series of patients (n=204), there were 26 cases of MABC. Besides, there were 18, 60, and 100 cases of luminal type, basal type and non-basal type, respectively. The MABC demonstrated apocrine histology and a higher prevalence of HER-2 positivity than other phenotypes. With the basal type, the MABC manifested a more frequent expression of CK5/6 and EGFR and a higher Ki-67 index than other phenotypes (p<0.001). There were no significant differences in patient prognosis between the phenotypes of breast cancer. Conclusions: MABC are distinguishable from other phenotypes based on the apocrine histology and a higher expression rate of HER-2.

UR - http://www.scopus.com/inward/record.url?scp=84863424724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863424724&partnerID=8YFLogxK

U2 - 10.4132/KoreanJPathol.2012.46.2.169

DO - 10.4132/KoreanJPathol.2012.46.2.169

M3 - Article

C2 - 23109997

AN - SCOPUS:84863424724

VL - 46

SP - 169

EP - 176

JO - Journal of Pathology and Translational Medicine

JF - Journal of Pathology and Translational Medicine

SN - 2383-7837

IS - 2

ER -