The comparison of cystatin C and creatinine as an accurate serum marker in the prediction of type 2 diabetic nephropathy

byungwan lee, Sung Hee Ihm, Moon Gi Choi, Hyung Joon Yoo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In a clinic-based, cross-sectional study of 320 type 2 diabetic patients, we staged the level of diabetic nephropathy (normoalbuminuric, microalbuminuric and macroalbuminuric stage) and estimated GFR based on serum creatinine and cystatin C (CysC). Serum creatinine and CysC levels were 0.91 ± 0.21 mg/dL and 0.87 ± 0.26 mg/L, respectively. Correlation coefficients between CysC-GFR and each of the creatinine-based GFR measurements (MDRD-GFR, Cockcroft-Gault-GFR, and CLcr) were 0.589, 0.569, and 0.479 (p < 0.001). Serum CysC was significantly lower in normoalbuminurics (0.83 ± 0.22) than in microalbuminurics and macroalbuminurics (0.94 ± 0.33 and 1.05 ± 0.28; p = 0.004 and p < 0.001). Of the estimations of GFR, significant differences among the groups were found on CysC-GFR and CLcr. CysC-GFR (mL/min) was statistically lower in macroalbuminurics (79.5 ± 30.5) than in normoalbuminurics (104.3 ± 30.9, p = 0.01). The logistic regression analyses showed that retinopathy, A1C, CysC, diabetic duration, and CysC-GFR were indicators to predict the development of microalbuminuria. Serum CysC seems to be more accurate serum marker than serum creatinine in evaluating a prognostic stage of type 2 diabetic nephropathy. Our study suggests that, in Korean type 2 diabetic patients, CysC-based GFR might be more valuable than creatinine-based GFR in the prediction of the microalbuminuric stage.

Original languageEnglish
Pages (from-to)428-434
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume78
Issue number3
DOIs
Publication statusPublished - 2007 Dec 1

Fingerprint

Cystatin C
Diabetic Nephropathies
Creatinine
Biomarkers
Serum
Cross-Sectional Studies
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{ce20976b234b4daeb3cc671bdaa9c69d,
title = "The comparison of cystatin C and creatinine as an accurate serum marker in the prediction of type 2 diabetic nephropathy",
abstract = "In a clinic-based, cross-sectional study of 320 type 2 diabetic patients, we staged the level of diabetic nephropathy (normoalbuminuric, microalbuminuric and macroalbuminuric stage) and estimated GFR based on serum creatinine and cystatin C (CysC). Serum creatinine and CysC levels were 0.91 ± 0.21 mg/dL and 0.87 ± 0.26 mg/L, respectively. Correlation coefficients between CysC-GFR and each of the creatinine-based GFR measurements (MDRD-GFR, Cockcroft-Gault-GFR, and CLcr) were 0.589, 0.569, and 0.479 (p < 0.001). Serum CysC was significantly lower in normoalbuminurics (0.83 ± 0.22) than in microalbuminurics and macroalbuminurics (0.94 ± 0.33 and 1.05 ± 0.28; p = 0.004 and p < 0.001). Of the estimations of GFR, significant differences among the groups were found on CysC-GFR and CLcr. CysC-GFR (mL/min) was statistically lower in macroalbuminurics (79.5 ± 30.5) than in normoalbuminurics (104.3 ± 30.9, p = 0.01). The logistic regression analyses showed that retinopathy, A1C, CysC, diabetic duration, and CysC-GFR were indicators to predict the development of microalbuminuria. Serum CysC seems to be more accurate serum marker than serum creatinine in evaluating a prognostic stage of type 2 diabetic nephropathy. Our study suggests that, in Korean type 2 diabetic patients, CysC-based GFR might be more valuable than creatinine-based GFR in the prediction of the microalbuminuric stage.",
author = "byungwan lee and Ihm, {Sung Hee} and Choi, {Moon Gi} and Yoo, {Hyung Joon}",
year = "2007",
month = "12",
day = "1",
doi = "10.1016/j.diabres.2007.06.015",
language = "English",
volume = "78",
pages = "428--434",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

The comparison of cystatin C and creatinine as an accurate serum marker in the prediction of type 2 diabetic nephropathy. / lee, byungwan; Ihm, Sung Hee; Choi, Moon Gi; Yoo, Hyung Joon.

In: Diabetes Research and Clinical Practice, Vol. 78, No. 3, 01.12.2007, p. 428-434.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The comparison of cystatin C and creatinine as an accurate serum marker in the prediction of type 2 diabetic nephropathy

AU - lee, byungwan

AU - Ihm, Sung Hee

AU - Choi, Moon Gi

AU - Yoo, Hyung Joon

PY - 2007/12/1

Y1 - 2007/12/1

N2 - In a clinic-based, cross-sectional study of 320 type 2 diabetic patients, we staged the level of diabetic nephropathy (normoalbuminuric, microalbuminuric and macroalbuminuric stage) and estimated GFR based on serum creatinine and cystatin C (CysC). Serum creatinine and CysC levels were 0.91 ± 0.21 mg/dL and 0.87 ± 0.26 mg/L, respectively. Correlation coefficients between CysC-GFR and each of the creatinine-based GFR measurements (MDRD-GFR, Cockcroft-Gault-GFR, and CLcr) were 0.589, 0.569, and 0.479 (p < 0.001). Serum CysC was significantly lower in normoalbuminurics (0.83 ± 0.22) than in microalbuminurics and macroalbuminurics (0.94 ± 0.33 and 1.05 ± 0.28; p = 0.004 and p < 0.001). Of the estimations of GFR, significant differences among the groups were found on CysC-GFR and CLcr. CysC-GFR (mL/min) was statistically lower in macroalbuminurics (79.5 ± 30.5) than in normoalbuminurics (104.3 ± 30.9, p = 0.01). The logistic regression analyses showed that retinopathy, A1C, CysC, diabetic duration, and CysC-GFR were indicators to predict the development of microalbuminuria. Serum CysC seems to be more accurate serum marker than serum creatinine in evaluating a prognostic stage of type 2 diabetic nephropathy. Our study suggests that, in Korean type 2 diabetic patients, CysC-based GFR might be more valuable than creatinine-based GFR in the prediction of the microalbuminuric stage.

AB - In a clinic-based, cross-sectional study of 320 type 2 diabetic patients, we staged the level of diabetic nephropathy (normoalbuminuric, microalbuminuric and macroalbuminuric stage) and estimated GFR based on serum creatinine and cystatin C (CysC). Serum creatinine and CysC levels were 0.91 ± 0.21 mg/dL and 0.87 ± 0.26 mg/L, respectively. Correlation coefficients between CysC-GFR and each of the creatinine-based GFR measurements (MDRD-GFR, Cockcroft-Gault-GFR, and CLcr) were 0.589, 0.569, and 0.479 (p < 0.001). Serum CysC was significantly lower in normoalbuminurics (0.83 ± 0.22) than in microalbuminurics and macroalbuminurics (0.94 ± 0.33 and 1.05 ± 0.28; p = 0.004 and p < 0.001). Of the estimations of GFR, significant differences among the groups were found on CysC-GFR and CLcr. CysC-GFR (mL/min) was statistically lower in macroalbuminurics (79.5 ± 30.5) than in normoalbuminurics (104.3 ± 30.9, p = 0.01). The logistic regression analyses showed that retinopathy, A1C, CysC, diabetic duration, and CysC-GFR were indicators to predict the development of microalbuminuria. Serum CysC seems to be more accurate serum marker than serum creatinine in evaluating a prognostic stage of type 2 diabetic nephropathy. Our study suggests that, in Korean type 2 diabetic patients, CysC-based GFR might be more valuable than creatinine-based GFR in the prediction of the microalbuminuric stage.

UR - http://www.scopus.com/inward/record.url?scp=35648952773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35648952773&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2007.06.015

DO - 10.1016/j.diabres.2007.06.015

M3 - Article

VL - 78

SP - 428

EP - 434

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 3

ER -