The Complete Sequence of Leishmania RNA Virus LRV2-1, a Virus of an Old World Parasite Strain

Scott M. Scheffter, Young T. Ro, In K. Chung, J. L. Patterson

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

A complete cDNA sequence is reported for LRV2-1, the first Leishmania RNA virus known to infect an Old World parasite, Leishmania major. Sequence analyses show that LRV2-1 differs significantly from members of the LRV1 genus which infect New World parasites. The data support a view that transmission of LRV is strictly vertical and suggest that LRV predate the divergence of Old and New World parasites. As a consequence of this divergence, conserved features can be identified for the first time in Leishmania virus proteins. A finding that the virus capsid and polymerase genes do not overlap is unique among the known Totiviridae and infers that a gag-pol fusion protein cannot be produced simply via tRNA slippage in LRV2-1.

Original languageEnglish
Article number71456
Pages (from-to)84-90
Number of pages7
JournalVirology
Volume212
Issue number1
DOIs
Publication statusPublished - 1995 Sep 10

All Science Journal Classification (ASJC) codes

  • Virology

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