The Complete Sequence of Leishmania RNA Virus LRV2-1, a Virus of an Old World Parasite Strain

Scott M. Scheffter, Young T. Ro, In Kwon Chung, J. L. Patterson

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

A complete cDNA sequence is reported for LRV2-1, the first Leishmania RNA virus known to infect an Old World parasite, Leishmania major. Sequence analyses show that LRV2-1 differs significantly from members of the LRV1 genus which infect New World parasites. The data support a view that transmission of LRV is strictly vertical and suggest that LRV predate the divergence of Old and New World parasites. As a consequence of this divergence, conserved features can be identified for the first time in Leishmania virus proteins. A finding that the virus capsid and polymerase genes do not overlap is unique among the known Totiviridae and infers that a gag-pol fusion protein cannot be produced simply via tRNA slippage in LRV2-1.

Original languageEnglish
Article number71456
Pages (from-to)84-90
Number of pages7
JournalVirology
Volume212
Issue number1
DOIs
Publication statusPublished - 1995 Sep 10

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Leishmania
RNA Viruses
Parasites
Viruses
Totiviridae
gag-pol Fusion Proteins
Leishmania major
Capsid
Prednisolone
Transfer RNA
Sequence Analysis
Complementary DNA
Genes
Proteins

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Scheffter, Scott M. ; Ro, Young T. ; Chung, In Kwon ; Patterson, J. L. / The Complete Sequence of Leishmania RNA Virus LRV2-1, a Virus of an Old World Parasite Strain. In: Virology. 1995 ; Vol. 212, No. 1. pp. 84-90.
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The Complete Sequence of Leishmania RNA Virus LRV2-1, a Virus of an Old World Parasite Strain. / Scheffter, Scott M.; Ro, Young T.; Chung, In Kwon; Patterson, J. L.

In: Virology, Vol. 212, No. 1, 71456, 10.09.1995, p. 84-90.

Research output: Contribution to journalArticle

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