The correlation between insulin resistance and the visceral fat to skeletal muscle ratio in middle-aged women

Chul Sik Kim, Joo Young Nam, Jong Suk Park, Dol Mi Kim, Soo Jee Yoon, Chul Woo Ahn, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh, Bong Soo Cha

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Abstract

Central obesity with visceral fat accumulation and the amount of skeletal muscle mass may influence insulin sensitivity via its capacity for glucose load uptake. We investigated the relationships among the following metabolic variables: ratio of fat area to skeletal muscle area (VMR), percent ideal body weight, body mass index, waist-to-hip circumference (WHR) and visceral fat to subcutaneous fat ratio (VSR) in 114 nondiabetic middle-aged women. Anthropometric parameters, lipid profiles and sex hormone- binding globulin were measured. Visceral and subcutaneous fat areas at the umbilical level and the skeletal muscle area at the mid-thigh level were measured and computed. 75-gram OGTT tests were performed, along with measuring plasma glucose, insulin and free fatty acid levels, according to which area under the curve of glucose (Glu-AUC), insulin (Ins-AUC), free fatty acid (FFA-AUC) and glucose/insulin ratio (GIR=Glu-AUC/Ins-AUC), were calculated. 1) Triglyceride was more correlated with VSR than VMR. 2) The independent anthropometric parameters for each metabolic variable were In conclusion, VMR for Ins-AUC, WHR for Glu-AUC and total cholesterol, and VSR for triglyceride. 3) For subjects with higher VMR, age, Ins-AUC and triglyceride were significantly higher. 4) Subjects with higher VNM were older and showed higher Ins-AUC and lower GIR than the subjects with lower VMR. In conclusion, VMR is an anthropometric parameter that reflects insulin resistance concerning glucose metabolism, and VSR is thought to be a good parameter that that reflects the serum lipid levels. Further prospective studies are necessary to reevaluate the visceral fat vs. skeletal muscle relationship.

Original languageEnglish
Pages (from-to)469-478
Number of pages10
JournalYonsei medical journal
Volume45
Issue number3
DOIs
Publication statusPublished - 2004 Jun 30

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Intra-Abdominal Fat
Area Under Curve
Insulin Resistance
Skeletal Muscle
Glucose
Triglycerides
Subcutaneous Fat
Insulin
Nonesterified Fatty Acids
Hip
Lipids
Umbilicus
Ideal Body Weight
Sex Hormone-Binding Globulin
Abdominal Obesity
Glucose Tolerance Test
Thigh
Body Mass Index
Fats
Cholesterol

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, C. S., Nam, J. Y., Park, J. S., Kim, D. M., Yoon, S. J., Ahn, C. W., ... Cha, B. S. (2004). The correlation between insulin resistance and the visceral fat to skeletal muscle ratio in middle-aged women. Yonsei medical journal, 45(3), 469-478. https://doi.org/10.3349/ymj.2004.45.3.469
Kim, Chul Sik ; Nam, Joo Young ; Park, Jong Suk ; Kim, Dol Mi ; Yoon, Soo Jee ; Ahn, Chul Woo ; Lim, Sung Kil ; Kim, Kyung Rae ; Lee, Hyun Chul ; Huh, Kap Bum ; Cha, Bong Soo. / The correlation between insulin resistance and the visceral fat to skeletal muscle ratio in middle-aged women. In: Yonsei medical journal. 2004 ; Vol. 45, No. 3. pp. 469-478.
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Kim, CS, Nam, JY, Park, JS, Kim, DM, Yoon, SJ, Ahn, CW, Lim, SK, Kim, KR, Lee, HC, Huh, KB & Cha, BS 2004, 'The correlation between insulin resistance and the visceral fat to skeletal muscle ratio in middle-aged women', Yonsei medical journal, vol. 45, no. 3, pp. 469-478. https://doi.org/10.3349/ymj.2004.45.3.469

The correlation between insulin resistance and the visceral fat to skeletal muscle ratio in middle-aged women. / Kim, Chul Sik; Nam, Joo Young; Park, Jong Suk; Kim, Dol Mi; Yoon, Soo Jee; Ahn, Chul Woo; Lim, Sung Kil; Kim, Kyung Rae; Lee, Hyun Chul; Huh, Kap Bum; Cha, Bong Soo.

In: Yonsei medical journal, Vol. 45, No. 3, 30.06.2004, p. 469-478.

Research output: Contribution to journalArticle

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T1 - The correlation between insulin resistance and the visceral fat to skeletal muscle ratio in middle-aged women

AU - Kim, Chul Sik

AU - Nam, Joo Young

AU - Park, Jong Suk

AU - Kim, Dol Mi

AU - Yoon, Soo Jee

AU - Ahn, Chul Woo

AU - Lim, Sung Kil

AU - Kim, Kyung Rae

AU - Lee, Hyun Chul

AU - Huh, Kap Bum

AU - Cha, Bong Soo

PY - 2004/6/30

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N2 - Central obesity with visceral fat accumulation and the amount of skeletal muscle mass may influence insulin sensitivity via its capacity for glucose load uptake. We investigated the relationships among the following metabolic variables: ratio of fat area to skeletal muscle area (VMR), percent ideal body weight, body mass index, waist-to-hip circumference (WHR) and visceral fat to subcutaneous fat ratio (VSR) in 114 nondiabetic middle-aged women. Anthropometric parameters, lipid profiles and sex hormone- binding globulin were measured. Visceral and subcutaneous fat areas at the umbilical level and the skeletal muscle area at the mid-thigh level were measured and computed. 75-gram OGTT tests were performed, along with measuring plasma glucose, insulin and free fatty acid levels, according to which area under the curve of glucose (Glu-AUC), insulin (Ins-AUC), free fatty acid (FFA-AUC) and glucose/insulin ratio (GIR=Glu-AUC/Ins-AUC), were calculated. 1) Triglyceride was more correlated with VSR than VMR. 2) The independent anthropometric parameters for each metabolic variable were In conclusion, VMR for Ins-AUC, WHR for Glu-AUC and total cholesterol, and VSR for triglyceride. 3) For subjects with higher VMR, age, Ins-AUC and triglyceride were significantly higher. 4) Subjects with higher VNM were older and showed higher Ins-AUC and lower GIR than the subjects with lower VMR. In conclusion, VMR is an anthropometric parameter that reflects insulin resistance concerning glucose metabolism, and VSR is thought to be a good parameter that that reflects the serum lipid levels. Further prospective studies are necessary to reevaluate the visceral fat vs. skeletal muscle relationship.

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