The Cystic Fibrosis Transmembrane Conductance Regulator's Expanding SNARE Interactome

Bor Luen Tang, Heon Yung Gee, Min Goo Lee

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) interacts with multiple N-ethylmaleimide sensitive factor attachment protein (SNARE) molecules largely via its N-terminal cytoplasmic domain. The earliest known among these SNAREs are the cognate Q-SNARE pair of Syntaxin 1A (STX1A) and SNAP23 on the plasma membrane. These SNAREs affect CFTR chloride channel gating. CFTR exocytosis/recycling in intestinal epithelial cells is dependent on another SNARE located in the apical plasma membrane, STX3. Members of the STX8/STX7/vesicle transport through interaction with t-SNAREs homolog 1b/VAMP8 SNARE complex, which function in early to late endosome/lysosome traffic, are all known to interact with CFTR. Two SNAREs, STX6 and STX16 that function at the trans-Golgi network (TGN), have now been revealed as members of the CFTR SNARE interactome. We summarize here the SNAREs that interact with CFTR and discuss the roles of these SNAREs in the intracellular trafficking of CFTR and CFTR-associated pathophysiology.

Original languageEnglish
Pages (from-to)364-371
Number of pages8
JournalTraffic
Volume12
Issue number4
DOIs
Publication statusPublished - 2011 Apr 1

Fingerprint

SNARE Proteins
Cystic Fibrosis Transmembrane Conductance Regulator
Cell membranes
Q-SNARE Proteins
N-Ethylmaleimide-Sensitive Proteins
Syntaxin 1
Cell Membrane
trans-Golgi Network
Transport Vesicles
Chloride Channels
Endosomes
Exocytosis
Lysosomes
Recycling
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Tang, Bor Luen ; Gee, Heon Yung ; Lee, Min Goo. / The Cystic Fibrosis Transmembrane Conductance Regulator's Expanding SNARE Interactome. In: Traffic. 2011 ; Vol. 12, No. 4. pp. 364-371.
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The Cystic Fibrosis Transmembrane Conductance Regulator's Expanding SNARE Interactome. / Tang, Bor Luen; Gee, Heon Yung; Lee, Min Goo.

In: Traffic, Vol. 12, No. 4, 01.04.2011, p. 364-371.

Research output: Contribution to journalReview article

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