The diagnostic value of the adenosine deaminase activity in the pleural fluid of renal transplant patients with tuberculous pleural effusion

Jae Ho Chung, Yu Seun Kim, Soon Il Kim, Kiil Park, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Sung Kyu Kim

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11 Citations (Scopus)

Abstract

The assessment of the adenosine deaminase activity (ADA) in the pleural effusion is used for the diagnosis of tuberculous pleural effusion (TPE). To examine whether the procedure can be applied to immunocompromised patients, we analyzed the ADA activity in the pleural fluid of renal transplant recipients. We studied 23 renal transplant patients with TPE (21 men and 2 women; the mean age, 33 years). They were treated at the Yonsei University Hospital between January 1985 and December 2001. Patients with granuloma in the pleural biopsy specimen or positive for Mycobacterium tuberculosis in the pleural fluid culture were recruited. The ADA activity in the pleural effusion of 23 renal transplant patients with TPE was compared with 23 immunocompetent patients with TPE. The mean ADA activity was 69.5 ± 4.6 in renal transplant patients and 65.0 ± 4.9 U/L in immunocompetent patients. Applying the 40 U/L cut-off point, the positivity of ADA was 91.3% in renal transplant patients, and 86.9% in immunocompetent patients. We thus concluded that the measurement of ADA in the pleural fluid is a useful means in the diagnosis of TPE in renal transplant patients.

Original languageEnglish
Pages (from-to)661-664
Number of pages4
JournalYonsei medical journal
Volume45
Issue number4
DOIs
Publication statusPublished - 2004 Aug 31

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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