The drug susceptibility profile and inducible resistance to macrolides of mycobacterium abscessus and mycobacterium massiliense in Korea

Song Yee Kim, Chang Ki Kim, Il Kwon Bae, Seok Hoon Jeong, Jae Joon Yim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Young Ae Kang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We conducted drug susceptibility testing (DST) against various antimicrobial agents, including new candidate drugs, and investigated the relationship between inducible resistance (IR) to macrolides and erm(41) gene in Mycobacterium abscessus complex. Sixty-two isolates of M. abscessus complex from 2 tertiary care hospitals in South Korea were tested against 10 antimicrobial agents. Thirty-five isolates were M. abscessus, and 27 were Mycobacterium massiliense. Amikacin, moxifloxacin, linezolid, clofazimine, and tigecycline were active against most isolates and cefoxitin and ciprofloxacin against moderate number of isolates. M. massiliense remained susceptible to macrolides; in contrast, M. abscessus became highly resistant on day 14 after incubation. DST pattern did not differ between clarithromycin and azithromycin. IR to clarithromycin was correlated with erm(41) genotype in M. abscessus. Variations in susceptibility to antimicrobial agents within species and the difference in DST patterns between M. abscessus and M. massiliense suggest that DST and identification of M. abscessus complex are significant before treatment.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume81
Issue number2
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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