The integrative modeling framework for the microbial fuel cell was presented. The metabolism for the microbial was investigated to optimize the electrochemical performance with in silico model. Dynamic electrochemical performance was analyzed with the integrated in silico modeling. This modeling suggested the integrative methodology as a emerging technology. The dynamic modeling realized the dynamic performance of the microbial fuel cell. The systematic analysis for the microbial fuel cell was performed and suggested the fundamental modeling structure to apply another potential microbial. This is an abstract of a paper presented at the AIChE Annual Meeting and Fall Showcase (Cincinnati, OH 10/30/2005-11/4/2005).