The Effect of apoM Polymorphism Associated with HDL Metabolism on Obese Korean Adults

Myoungsook Lee, Jung Im Kim, Seojin Choi, Yangsoo Jang, Sungbin Richard Sorn

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported. Aim: To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults. Methods: A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined. Results: In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2% higher diastolic blood pressure (DBP), 1.3% lower amount of HDL2b subfraction, and 19.7% higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43% higher plasma insulin, 17.7% higher total cholesterol, 26.7% higher triglyceride, 40.7% higher leptin, 1.6% lower HDL2b, and 12.6% higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes. Conclusion: apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.

Original languageEnglish
Pages (from-to)306-317
Number of pages12
JournalJournal of Nutrigenetics and Nutrigenomics
Volume9
Issue number5-6
DOIs
Publication statusPublished - 2017 Apr 1

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apolipoproteins
Apolipoproteins
high density lipoprotein
HDL Lipoproteins
genetic polymorphism
metabolism
phosphatidylcholine-choline acyltransferase
Phosphatidylcholine-Sterol O-Acyltransferase
obesity
Obesity
Alleles
Cholesterol
cholesterol
alleles
Insulin
diastolic blood pressure
Enzymes
Korea
enzymes
Leptin

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science
  • Genetics

Cite this

Lee, Myoungsook ; Kim, Jung Im ; Choi, Seojin ; Jang, Yangsoo ; Sorn, Sungbin Richard. / The Effect of apoM Polymorphism Associated with HDL Metabolism on Obese Korean Adults. In: Journal of Nutrigenetics and Nutrigenomics. 2017 ; Vol. 9, No. 5-6. pp. 306-317.
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abstract = "Background: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported. Aim: To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults. Methods: A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined. Results: In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2{\%} higher diastolic blood pressure (DBP), 1.3{\%} lower amount of HDL2b subfraction, and 19.7{\%} higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43{\%} higher plasma insulin, 17.7{\%} higher total cholesterol, 26.7{\%} higher triglyceride, 40.7{\%} higher leptin, 1.6{\%} lower HDL2b, and 12.6{\%} higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes. Conclusion: apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.",
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The Effect of apoM Polymorphism Associated with HDL Metabolism on Obese Korean Adults. / Lee, Myoungsook; Kim, Jung Im; Choi, Seojin; Jang, Yangsoo; Sorn, Sungbin Richard.

In: Journal of Nutrigenetics and Nutrigenomics, Vol. 9, No. 5-6, 01.04.2017, p. 306-317.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Effect of apoM Polymorphism Associated with HDL Metabolism on Obese Korean Adults

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AU - Kim, Jung Im

AU - Choi, Seojin

AU - Jang, Yangsoo

AU - Sorn, Sungbin Richard

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N2 - Background: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported. Aim: To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults. Methods: A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined. Results: In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2% higher diastolic blood pressure (DBP), 1.3% lower amount of HDL2b subfraction, and 19.7% higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43% higher plasma insulin, 17.7% higher total cholesterol, 26.7% higher triglyceride, 40.7% higher leptin, 1.6% lower HDL2b, and 12.6% higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes. Conclusion: apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.

AB - Background: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported. Aim: To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults. Methods: A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined. Results: In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2% higher diastolic blood pressure (DBP), 1.3% lower amount of HDL2b subfraction, and 19.7% higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43% higher plasma insulin, 17.7% higher total cholesterol, 26.7% higher triglyceride, 40.7% higher leptin, 1.6% lower HDL2b, and 12.6% higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes. Conclusion: apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.

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