Abstract
Background: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported. Aim: To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults. Methods: A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined. Results: In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2% higher diastolic blood pressure (DBP), 1.3% lower amount of HDL2b subfraction, and 19.7% higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43% higher plasma insulin, 17.7% higher total cholesterol, 26.7% higher triglyceride, 40.7% higher leptin, 1.6% lower HDL2b, and 12.6% higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes. Conclusion: apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.
| Original language | English |
|---|---|
| Pages (from-to) | 306-317 |
| Number of pages | 12 |
| Journal | Journal of Nutrigenetics and Nutrigenomics |
| Volume | 9 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 2017 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Food Science
- Genetics
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The Effect of apoM Polymorphism Associated with HDL Metabolism on Obese Korean Adults. / Lee, Myoungsook; Kim, Jung Im; Choi, Seojin; Jang, Yangsoo; Sorn, Sungbin Richard.
In: Journal of Nutrigenetics and Nutrigenomics, Vol. 9, No. 5-6, 01.04.2017, p. 306-317.Research output: Contribution to journal › Article
TY - JOUR
T1 - The Effect of apoM Polymorphism Associated with HDL Metabolism on Obese Korean Adults
AU - Lee, Myoungsook
AU - Kim, Jung Im
AU - Choi, Seojin
AU - Jang, Yangsoo
AU - Sorn, Sungbin Richard
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported. Aim: To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults. Methods: A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined. Results: In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2% higher diastolic blood pressure (DBP), 1.3% lower amount of HDL2b subfraction, and 19.7% higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43% higher plasma insulin, 17.7% higher total cholesterol, 26.7% higher triglyceride, 40.7% higher leptin, 1.6% lower HDL2b, and 12.6% higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes. Conclusion: apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.
AB - Background: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported. Aim: To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults. Methods: A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined. Results: In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2% higher diastolic blood pressure (DBP), 1.3% lower amount of HDL2b subfraction, and 19.7% higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43% higher plasma insulin, 17.7% higher total cholesterol, 26.7% higher triglyceride, 40.7% higher leptin, 1.6% lower HDL2b, and 12.6% higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes. Conclusion: apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.
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UR - http://www.scopus.com/inward/citedby.url?scp=85014108610&partnerID=8YFLogxK
U2 - 10.1159/000455948
DO - 10.1159/000455948
M3 - Article
C2 - 28245483
AN - SCOPUS:85014108610
VL - 9
SP - 306
EP - 317
JO - Lifestyle Genomics
JF - Lifestyle Genomics
SN - 2504-3161
IS - 5-6
ER -