Abstract
Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.
| Original language | English |
|---|---|
| Pages (from-to) | 349-366 |
| Number of pages | 18 |
| Journal | Journal of Preventive Medicine and Public Health |
| Volume | 49 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2016 Nov |
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All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
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The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer : A systematic review and meta-analysis. / Sung, Ho Kyung; Ma, Seung Hyun; Choi, Ji Yeob; Hwang, Yunji; Ahn, Choonghyun; Kim, Byoung Gie; Kim, Yong Man; Kim, Jae Weon; Kang, Sokbom; Kim, Jaehoon; Kim, Tae Jin; Yoo, Keun Young; Kang, Daehee; Park, Suekyung.
In: Journal of Preventive Medicine and Public Health, Vol. 49, No. 6, 11.2016, p. 349-366.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer
T2 - A systematic review and meta-analysis
AU - Sung, Ho Kyung
AU - Ma, Seung Hyun
AU - Choi, Ji Yeob
AU - Hwang, Yunji
AU - Ahn, Choonghyun
AU - Kim, Byoung Gie
AU - Kim, Yong Man
AU - Kim, Jae Weon
AU - Kang, Sokbom
AU - Kim, Jaehoon
AU - Kim, Tae Jin
AU - Yoo, Keun Young
AU - Kang, Daehee
AU - Park, Suekyung
PY - 2016/11
Y1 - 2016/11
N2 - Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.
AB - Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.
UR - http://www.scopus.com/inward/record.url?scp=85012878287&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85012878287&partnerID=8YFLogxK
U2 - 10.3961/jpmph.16.066
DO - 10.3961/jpmph.16.066
M3 - Review article
C2 - 27951628
AN - SCOPUS:85012878287
VL - 49
SP - 349
EP - 366
JO - Journal of Preventive Medicine and Public Health
JF - Journal of Preventive Medicine and Public Health
SN - 1975-8375
IS - 6
ER -