The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer: A systematic review and meta-analysis

Ho Kyung Sung, Seung Hyun Ma, Ji Yeob Choi, Yunji Hwang, Choonghyun Ahn, Byoung Gie Kim, Yong Man Kim, Jae Weon Kim, Sokbom Kang, Jaehoon Kim, Tae Jin Kim, Keun Young Yoo, Daehee Kang, Suekyung Park

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.

Original languageEnglish
Pages (from-to)349-366
Number of pages18
JournalJournal of Preventive Medicine and Public Health
Volume49
Issue number6
DOIs
Publication statusPublished - 2016 Nov

Fingerprint

Parity
Breast Feeding
Meta-Analysis
Confidence Intervals
Parturition
Birth Order
Ovarian epithelial cancer
PubMed

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Sung, Ho Kyung ; Ma, Seung Hyun ; Choi, Ji Yeob ; Hwang, Yunji ; Ahn, Choonghyun ; Kim, Byoung Gie ; Kim, Yong Man ; Kim, Jae Weon ; Kang, Sokbom ; Kim, Jaehoon ; Kim, Tae Jin ; Yoo, Keun Young ; Kang, Daehee ; Park, Suekyung. / The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer : A systematic review and meta-analysis. In: Journal of Preventive Medicine and Public Health. 2016 ; Vol. 49, No. 6. pp. 349-366.
@article{b608f29cd7ff49aeb97232aa2644693b,
title = "The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer: A systematic review and meta-analysis",
abstract = "Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95{\%} confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95{\%} CI, 0.65 to 0.79), 0.57 (95{\%} CI, 0.49 to 0.65), and 0.46 (95{\%} CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9{\%}). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95{\%} CI, 0.72 to 0.87), 0.72 (95{\%} CI, 0.64 to 0.81), and 0.67 (95{\%} CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5{\%}). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.",
author = "Sung, {Ho Kyung} and Ma, {Seung Hyun} and Choi, {Ji Yeob} and Yunji Hwang and Choonghyun Ahn and Kim, {Byoung Gie} and Kim, {Yong Man} and Kim, {Jae Weon} and Sokbom Kang and Jaehoon Kim and Kim, {Tae Jin} and Yoo, {Keun Young} and Daehee Kang and Suekyung Park",
year = "2016",
month = "11",
doi = "10.3961/jpmph.16.066",
language = "English",
volume = "49",
pages = "349--366",
journal = "Journal of Preventive Medicine and Public Health",
issn = "1975-8375",
publisher = "Korean Society for Preventive Medicine",
number = "6",

}

Sung, HK, Ma, SH, Choi, JY, Hwang, Y, Ahn, C, Kim, BG, Kim, YM, Kim, JW, Kang, S, Kim, J, Kim, TJ, Yoo, KY, Kang, D & Park, S 2016, 'The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer: A systematic review and meta-analysis', Journal of Preventive Medicine and Public Health, vol. 49, no. 6, pp. 349-366. https://doi.org/10.3961/jpmph.16.066

The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer : A systematic review and meta-analysis. / Sung, Ho Kyung; Ma, Seung Hyun; Choi, Ji Yeob; Hwang, Yunji; Ahn, Choonghyun; Kim, Byoung Gie; Kim, Yong Man; Kim, Jae Weon; Kang, Sokbom; Kim, Jaehoon; Kim, Tae Jin; Yoo, Keun Young; Kang, Daehee; Park, Suekyung.

In: Journal of Preventive Medicine and Public Health, Vol. 49, No. 6, 11.2016, p. 349-366.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer

T2 - A systematic review and meta-analysis

AU - Sung, Ho Kyung

AU - Ma, Seung Hyun

AU - Choi, Ji Yeob

AU - Hwang, Yunji

AU - Ahn, Choonghyun

AU - Kim, Byoung Gie

AU - Kim, Yong Man

AU - Kim, Jae Weon

AU - Kang, Sokbom

AU - Kim, Jaehoon

AU - Kim, Tae Jin

AU - Yoo, Keun Young

AU - Kang, Daehee

AU - Park, Suekyung

PY - 2016/11

Y1 - 2016/11

N2 - Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.

AB - Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.

UR - http://www.scopus.com/inward/record.url?scp=85012878287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012878287&partnerID=8YFLogxK

U2 - 10.3961/jpmph.16.066

DO - 10.3961/jpmph.16.066

M3 - Review article

C2 - 27951628

AN - SCOPUS:85012878287

VL - 49

SP - 349

EP - 366

JO - Journal of Preventive Medicine and Public Health

JF - Journal of Preventive Medicine and Public Health

SN - 1975-8375

IS - 6

ER -