Abstract
This study was performed to assess the influence of the cryoinjury on the dynamics of wavefronts and to determine whether they can convert ventricular fibrillation (VF) to ventricular tachycardia (VT) in fibrillating right ventricular (RV) of swines using an optical mapping system. A cryoinjury with a diameter of 12 mm was created on the epicardium of perfused RV of swines (n=6) and optical mapping were taken from baseline until 10 minutes after the cryoinjury. Out of 35 cryoinjuries, the images were possible to be interpreted in 32. The optical action potential could not be observed in either the cryoinjury or peri-injury sites at 1 and 3 minutes, was observed in only the cryoinjury site at 5 minutes, and recovered in both sites at 10 minutes. The cycle length of the tachycardia was 135.9 ± 23.6 msec at baseline, 176.2 ± 79.3 msec at 1 minute, 187.6 ± 97.9 msec at 3 minutes, 185.5 ± 19.2 msec at 5 minutes, and 152.1 ± 64.1 msec at 10 minutes. The cycle lengths at 1, 3, and 5 minutes after the cryoinjury were significantly more prolonged than that at baseline (p = 0.001, p=0.006, p=0.016). After the cryoinjury, the VF changed to VT in 9 (28.0%), and terminated in 2 (6,3%). These changes were observed mainly within 5 minutes after cryoinjury. The cryoinjury had anti-fibrillatory effects on the issue with VF This phenomenon was related to a decreasing mass and stabilizing wavefronts.
| Original language | English |
|---|---|
| Pages (from-to) | 672-679 |
| Number of pages | 8 |
| Journal | Yonsei medical journal |
| Volume | 47 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2006 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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The effect of cryoinjury on ventricular tachycardia in the swine right ventricle. / Joung, Boyoung; Xu, Zhengzhe; Kim, Ilkwon; Lee, Moon Hyoung; Kim, Sungsoon.
In: Yonsei medical journal, Vol. 47, No. 5, 01.10.2006, p. 672-679.Research output: Contribution to journal › Article
TY - JOUR
T1 - The effect of cryoinjury on ventricular tachycardia in the swine right ventricle
AU - Joung, Boyoung
AU - Xu, Zhengzhe
AU - Kim, Ilkwon
AU - Lee, Moon Hyoung
AU - Kim, Sungsoon
PY - 2006/10/1
Y1 - 2006/10/1
N2 - This study was performed to assess the influence of the cryoinjury on the dynamics of wavefronts and to determine whether they can convert ventricular fibrillation (VF) to ventricular tachycardia (VT) in fibrillating right ventricular (RV) of swines using an optical mapping system. A cryoinjury with a diameter of 12 mm was created on the epicardium of perfused RV of swines (n=6) and optical mapping were taken from baseline until 10 minutes after the cryoinjury. Out of 35 cryoinjuries, the images were possible to be interpreted in 32. The optical action potential could not be observed in either the cryoinjury or peri-injury sites at 1 and 3 minutes, was observed in only the cryoinjury site at 5 minutes, and recovered in both sites at 10 minutes. The cycle length of the tachycardia was 135.9 ± 23.6 msec at baseline, 176.2 ± 79.3 msec at 1 minute, 187.6 ± 97.9 msec at 3 minutes, 185.5 ± 19.2 msec at 5 minutes, and 152.1 ± 64.1 msec at 10 minutes. The cycle lengths at 1, 3, and 5 minutes after the cryoinjury were significantly more prolonged than that at baseline (p = 0.001, p=0.006, p=0.016). After the cryoinjury, the VF changed to VT in 9 (28.0%), and terminated in 2 (6,3%). These changes were observed mainly within 5 minutes after cryoinjury. The cryoinjury had anti-fibrillatory effects on the issue with VF This phenomenon was related to a decreasing mass and stabilizing wavefronts.
AB - This study was performed to assess the influence of the cryoinjury on the dynamics of wavefronts and to determine whether they can convert ventricular fibrillation (VF) to ventricular tachycardia (VT) in fibrillating right ventricular (RV) of swines using an optical mapping system. A cryoinjury with a diameter of 12 mm was created on the epicardium of perfused RV of swines (n=6) and optical mapping were taken from baseline until 10 minutes after the cryoinjury. Out of 35 cryoinjuries, the images were possible to be interpreted in 32. The optical action potential could not be observed in either the cryoinjury or peri-injury sites at 1 and 3 minutes, was observed in only the cryoinjury site at 5 minutes, and recovered in both sites at 10 minutes. The cycle length of the tachycardia was 135.9 ± 23.6 msec at baseline, 176.2 ± 79.3 msec at 1 minute, 187.6 ± 97.9 msec at 3 minutes, 185.5 ± 19.2 msec at 5 minutes, and 152.1 ± 64.1 msec at 10 minutes. The cycle lengths at 1, 3, and 5 minutes after the cryoinjury were significantly more prolonged than that at baseline (p = 0.001, p=0.006, p=0.016). After the cryoinjury, the VF changed to VT in 9 (28.0%), and terminated in 2 (6,3%). These changes were observed mainly within 5 minutes after cryoinjury. The cryoinjury had anti-fibrillatory effects on the issue with VF This phenomenon was related to a decreasing mass and stabilizing wavefronts.
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U2 - 10.3349/ymj.2006.47.5.672
DO - 10.3349/ymj.2006.47.5.672
M3 - Article
C2 - 17066511
AN - SCOPUS:33750683921
VL - 47
SP - 672
EP - 679
JO - Yonsei Medical Journal
JF - Yonsei Medical Journal
SN - 0513-5796
IS - 5
ER -