The effect of dexmedetomidine on intraocular pressure increase in patients during robot-Assisted laparoscopic radical prostatectomy in the steep trendelenburg position

Na Young Kim, Young Chul Yoo, Heejoon Park, Young Deuk Choi, Chan Yun Kim, Sun Joon Bai

Research output: Contribution to journalArticle

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Abstract

Purpose: This study was to evaluate the effect of intraoperative continuous infusion of dexmedetomidine on intraocular pressure (IOP) in patients undergoing robot-Assisted laparoscopic radical prostatectomy (RALRP) in the steep Trendelenburg (ST). Materials and Methods: Sixty-eight patients were randomly divided into two groups. The dexmedetomidine group (Group D, n=34) received a continuous infusion of dexmedetomidine at a rate of 0.4μg kg-1 hour-1 from the induction of anesthesia until the end of the ST position, while the control group (Group C, n=34) received an equal volume of physiologic saline at the same rate under conventional general anesthesia with sevoflurane and remifentanil. IOP was measured at 11 predefined time points for all patients. Results: Significant differences in IOP were detected between the two groups by a linear mixed model analysis (p<0.001). The highest mean IOP was 19.9±5.0mm Hg in Group D and 25.7±5.0mm Hg in Group C; both were measured 60 minutes after the patients had been placed in the ST position. No significant between-group differences in ocular perfusion pressure, mean blood pressure, or heart rate were observed between the two groups. No ocular or other complications were noted. Conclusion: Intraoperative continuous infusion of dexmedetomidine may help alleviate IOP increase in patients undergoing RALRP in the ST position.

Original languageEnglish
Pages (from-to)310-316
Number of pages7
JournalJournal of Endourology
Volume29
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

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Dexmedetomidine
Prostatectomy
Intraocular Pressure
General Anesthesia
Linear Models
Anesthesia
Perfusion
Heart Rate
Blood Pressure
Pressure
Control Groups

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

@article{d9d2f0f5f11a4b4c966d9f25ea6e9f70,
title = "The effect of dexmedetomidine on intraocular pressure increase in patients during robot-Assisted laparoscopic radical prostatectomy in the steep trendelenburg position",
abstract = "Purpose: This study was to evaluate the effect of intraoperative continuous infusion of dexmedetomidine on intraocular pressure (IOP) in patients undergoing robot-Assisted laparoscopic radical prostatectomy (RALRP) in the steep Trendelenburg (ST). Materials and Methods: Sixty-eight patients were randomly divided into two groups. The dexmedetomidine group (Group D, n=34) received a continuous infusion of dexmedetomidine at a rate of 0.4μg kg-1 hour-1 from the induction of anesthesia until the end of the ST position, while the control group (Group C, n=34) received an equal volume of physiologic saline at the same rate under conventional general anesthesia with sevoflurane and remifentanil. IOP was measured at 11 predefined time points for all patients. Results: Significant differences in IOP were detected between the two groups by a linear mixed model analysis (p<0.001). The highest mean IOP was 19.9±5.0mm Hg in Group D and 25.7±5.0mm Hg in Group C; both were measured 60 minutes after the patients had been placed in the ST position. No significant between-group differences in ocular perfusion pressure, mean blood pressure, or heart rate were observed between the two groups. No ocular or other complications were noted. Conclusion: Intraoperative continuous infusion of dexmedetomidine may help alleviate IOP increase in patients undergoing RALRP in the ST position.",
author = "Kim, {Na Young} and Yoo, {Young Chul} and Heejoon Park and Choi, {Young Deuk} and Kim, {Chan Yun} and Bai, {Sun Joon}",
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The effect of dexmedetomidine on intraocular pressure increase in patients during robot-Assisted laparoscopic radical prostatectomy in the steep trendelenburg position. / Kim, Na Young; Yoo, Young Chul; Park, Heejoon; Choi, Young Deuk; Kim, Chan Yun; Bai, Sun Joon.

In: Journal of Endourology, Vol. 29, No. 3, 01.03.2015, p. 310-316.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of dexmedetomidine on intraocular pressure increase in patients during robot-Assisted laparoscopic radical prostatectomy in the steep trendelenburg position

AU - Kim, Na Young

AU - Yoo, Young Chul

AU - Park, Heejoon

AU - Choi, Young Deuk

AU - Kim, Chan Yun

AU - Bai, Sun Joon

PY - 2015/3/1

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N2 - Purpose: This study was to evaluate the effect of intraoperative continuous infusion of dexmedetomidine on intraocular pressure (IOP) in patients undergoing robot-Assisted laparoscopic radical prostatectomy (RALRP) in the steep Trendelenburg (ST). Materials and Methods: Sixty-eight patients were randomly divided into two groups. The dexmedetomidine group (Group D, n=34) received a continuous infusion of dexmedetomidine at a rate of 0.4μg kg-1 hour-1 from the induction of anesthesia until the end of the ST position, while the control group (Group C, n=34) received an equal volume of physiologic saline at the same rate under conventional general anesthesia with sevoflurane and remifentanil. IOP was measured at 11 predefined time points for all patients. Results: Significant differences in IOP were detected between the two groups by a linear mixed model analysis (p<0.001). The highest mean IOP was 19.9±5.0mm Hg in Group D and 25.7±5.0mm Hg in Group C; both were measured 60 minutes after the patients had been placed in the ST position. No significant between-group differences in ocular perfusion pressure, mean blood pressure, or heart rate were observed between the two groups. No ocular or other complications were noted. Conclusion: Intraoperative continuous infusion of dexmedetomidine may help alleviate IOP increase in patients undergoing RALRP in the ST position.

AB - Purpose: This study was to evaluate the effect of intraoperative continuous infusion of dexmedetomidine on intraocular pressure (IOP) in patients undergoing robot-Assisted laparoscopic radical prostatectomy (RALRP) in the steep Trendelenburg (ST). Materials and Methods: Sixty-eight patients were randomly divided into two groups. The dexmedetomidine group (Group D, n=34) received a continuous infusion of dexmedetomidine at a rate of 0.4μg kg-1 hour-1 from the induction of anesthesia until the end of the ST position, while the control group (Group C, n=34) received an equal volume of physiologic saline at the same rate under conventional general anesthesia with sevoflurane and remifentanil. IOP was measured at 11 predefined time points for all patients. Results: Significant differences in IOP were detected between the two groups by a linear mixed model analysis (p<0.001). The highest mean IOP was 19.9±5.0mm Hg in Group D and 25.7±5.0mm Hg in Group C; both were measured 60 minutes after the patients had been placed in the ST position. No significant between-group differences in ocular perfusion pressure, mean blood pressure, or heart rate were observed between the two groups. No ocular or other complications were noted. Conclusion: Intraoperative continuous infusion of dexmedetomidine may help alleviate IOP increase in patients undergoing RALRP in the ST position.

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