The effect of growth hormone treatment on craniofacial growth in short stature children

Sung Ho Chung, Jin Wook Kim, Yong Hoon Park, ChungJu Hwang, Hee Kyung Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: The purpose of this study was to analyze the effect of growth hormone treatment (GHT) on craniofacial growth in children of short stature. Methods: Nineteen untreated children of short stature were referred from the Pediatric Department, Yeungnam University Hospital as a subject group. All subjects had lateral cephalograms taken before, after 1 year and after 2 years of growth hormone treatment. As a reference group, we selected 19 normal children with paired sampling who matched the subjects' age and sex, from the Department of Orthodontics, Kyungpook National University Hospital. Results: Before GHT, anterior cranial base length and upper posterior facial height, posterior total facial height, mandibular ramus length, and mandibular corpus length were significantly smaller in the reference group. In angular craniofacial measurements, saddle angle and mandibular plane angle were larger. SNA and SNB were smaller in the reference group. After two years of GHT, growth hormone accelerated growth in several craniofacial components. The posterior total facial height, the anterior, posterior cranial base length, and the mandibular ramus length were increased. And the difference in mandibular plane angle and ANB values compared with the reference group was decreased. Conclusions: GHT over 2 years leads to a craniofacial catch-up growth tendency, which is pronounced in interstitial cartilage and condylar cartilage.

Original languageEnglish
Pages (from-to)227-238
Number of pages12
JournalKorean Journal of Orthodontics
Volume40
Issue number4
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Growth Hormone
Growth
Skull Base
Cartilage
Therapeutics
Orthodontics
Pediatrics

All Science Journal Classification (ASJC) codes

  • Orthodontics

Cite this

Chung, Sung Ho ; Kim, Jin Wook ; Park, Yong Hoon ; Hwang, ChungJu ; Lee, Hee Kyung. / The effect of growth hormone treatment on craniofacial growth in short stature children. In: Korean Journal of Orthodontics. 2010 ; Vol. 40, No. 4. pp. 227-238.
@article{6e51137ab4a94373839f727df0f15d1b,
title = "The effect of growth hormone treatment on craniofacial growth in short stature children",
abstract = "Objective: The purpose of this study was to analyze the effect of growth hormone treatment (GHT) on craniofacial growth in children of short stature. Methods: Nineteen untreated children of short stature were referred from the Pediatric Department, Yeungnam University Hospital as a subject group. All subjects had lateral cephalograms taken before, after 1 year and after 2 years of growth hormone treatment. As a reference group, we selected 19 normal children with paired sampling who matched the subjects' age and sex, from the Department of Orthodontics, Kyungpook National University Hospital. Results: Before GHT, anterior cranial base length and upper posterior facial height, posterior total facial height, mandibular ramus length, and mandibular corpus length were significantly smaller in the reference group. In angular craniofacial measurements, saddle angle and mandibular plane angle were larger. SNA and SNB were smaller in the reference group. After two years of GHT, growth hormone accelerated growth in several craniofacial components. The posterior total facial height, the anterior, posterior cranial base length, and the mandibular ramus length were increased. And the difference in mandibular plane angle and ANB values compared with the reference group was decreased. Conclusions: GHT over 2 years leads to a craniofacial catch-up growth tendency, which is pronounced in interstitial cartilage and condylar cartilage.",
author = "Chung, {Sung Ho} and Kim, {Jin Wook} and Park, {Yong Hoon} and ChungJu Hwang and Lee, {Hee Kyung}",
year = "2010",
month = "8",
day = "1",
doi = "10.4041/kjod.2010.40.4.227",
language = "English",
volume = "40",
pages = "227--238",
journal = "Korean Journal of Orthodontics",
issn = "2234-7518",
publisher = "Korean Association of Orthodontists",
number = "4",

}

The effect of growth hormone treatment on craniofacial growth in short stature children. / Chung, Sung Ho; Kim, Jin Wook; Park, Yong Hoon; Hwang, ChungJu; Lee, Hee Kyung.

In: Korean Journal of Orthodontics, Vol. 40, No. 4, 01.08.2010, p. 227-238.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of growth hormone treatment on craniofacial growth in short stature children

AU - Chung, Sung Ho

AU - Kim, Jin Wook

AU - Park, Yong Hoon

AU - Hwang, ChungJu

AU - Lee, Hee Kyung

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Objective: The purpose of this study was to analyze the effect of growth hormone treatment (GHT) on craniofacial growth in children of short stature. Methods: Nineteen untreated children of short stature were referred from the Pediatric Department, Yeungnam University Hospital as a subject group. All subjects had lateral cephalograms taken before, after 1 year and after 2 years of growth hormone treatment. As a reference group, we selected 19 normal children with paired sampling who matched the subjects' age and sex, from the Department of Orthodontics, Kyungpook National University Hospital. Results: Before GHT, anterior cranial base length and upper posterior facial height, posterior total facial height, mandibular ramus length, and mandibular corpus length were significantly smaller in the reference group. In angular craniofacial measurements, saddle angle and mandibular plane angle were larger. SNA and SNB were smaller in the reference group. After two years of GHT, growth hormone accelerated growth in several craniofacial components. The posterior total facial height, the anterior, posterior cranial base length, and the mandibular ramus length were increased. And the difference in mandibular plane angle and ANB values compared with the reference group was decreased. Conclusions: GHT over 2 years leads to a craniofacial catch-up growth tendency, which is pronounced in interstitial cartilage and condylar cartilage.

AB - Objective: The purpose of this study was to analyze the effect of growth hormone treatment (GHT) on craniofacial growth in children of short stature. Methods: Nineteen untreated children of short stature were referred from the Pediatric Department, Yeungnam University Hospital as a subject group. All subjects had lateral cephalograms taken before, after 1 year and after 2 years of growth hormone treatment. As a reference group, we selected 19 normal children with paired sampling who matched the subjects' age and sex, from the Department of Orthodontics, Kyungpook National University Hospital. Results: Before GHT, anterior cranial base length and upper posterior facial height, posterior total facial height, mandibular ramus length, and mandibular corpus length were significantly smaller in the reference group. In angular craniofacial measurements, saddle angle and mandibular plane angle were larger. SNA and SNB were smaller in the reference group. After two years of GHT, growth hormone accelerated growth in several craniofacial components. The posterior total facial height, the anterior, posterior cranial base length, and the mandibular ramus length were increased. And the difference in mandibular plane angle and ANB values compared with the reference group was decreased. Conclusions: GHT over 2 years leads to a craniofacial catch-up growth tendency, which is pronounced in interstitial cartilage and condylar cartilage.

UR - http://www.scopus.com/inward/record.url?scp=77956629501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956629501&partnerID=8YFLogxK

U2 - 10.4041/kjod.2010.40.4.227

DO - 10.4041/kjod.2010.40.4.227

M3 - Article

VL - 40

SP - 227

EP - 238

JO - Korean Journal of Orthodontics

JF - Korean Journal of Orthodontics

SN - 2234-7518

IS - 4

ER -