Finding a way to strengthen human cognitive functions, such as learning and memory, has been of great concern since the moment people realized that these functions can be affected and even altered by certain chemicals. Since then, plenty of endeavors have been made to look for safe ways of improving cognitive performances without adverse side-effects. Unfortunately, most of these efforts have turned out to be unsuccessful until now. In this study, we examine the effect of a natural compound, idesolide, on hippocampus-dependent recognition memory. We demonstrate that idesolide is effective in the enhancement of recognition memory, as measured by a novel object recognition task. Thus, idesolide might serve as a novel therapeutic medication for the treatment of memory-related brain anomalies such as mild cognitive impairment (MCI) and Alzheimer's disease.
Bibliographical noteFunding Information:
This work was supported by the Korea Ministry of Science and Technology under the Brain Research Center-Frontier Program (M103KV010008-06K2201-00810) and Hye-Ryeon Lee was supported by Seoul Science Fellowship.
All Science Journal Classification (ASJC) codes
- Animal Science and Zoology
- Biochemistry, Genetics and Molecular Biology(all)