The effect of interferon-free regimens on health-related quality of life in East Asian patients with chronic hepatitis C

Zobair M. Younossi, Maria Stepanova, Linda Henry, Kwang Hyub Han, Sang Hoon Ahn, Young Suk Lim, Wan Long Chuang, Jia Horng Kao, Nguyen Kinh, Ching Lung Lai, Man Fung Yuen, Henry Lik Yuen Chan, Wei Lai

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Abstract

Background: Interferon (IFN)-based regimens cause significant impairment of health-related quality of life (HRQL). Hepatitis C virus (HCV) cure with IFN-free regimens improves HRQL. The effect of these regimens on HRQL in East Asian HCV patients is unclear due to lack of published evidence. Aim: To assess HRQL in East Asian HCV patients treated with an IFN-free regimen with sofosbuvir+ribavirin. Methods: Patients completed Short Form-36 (SF-36) before, during and after treatment. Results: 686 subjects were included (China: 56.7%; S. Korea: 18.8%; Taiwan: 12.7%; genotype 2: 40.8%; genotype 1: 29.6%; genotype 3: 18.4%; genotype 6: 11.2%; cirrhosis: 13.4%; treatment-naïve: 66.5%). Patients received either pegylated-IFN, sofosbuvir, and ribavirin (IFN+SOF+RBV) for 12 weeks (n = 155, genotypes 1 and 6) or SOF+RBV for 12-24 weeks (n = 531, all genotypes). The SVR-12 rates were 95.5% and 96.0%; respectively (P =.76). Baseline HRQL scores were similar between treatment groups (all P >.05). By the end of treatment, the IFN-treated group experienced significant declines in most HRQL scores (on average, by up to −13.3 points on a 0-100 scale from the baseline level, P <.02) while subjects on SOF/RBV had milder impairments (up to −5.4 points). Achieving SVR-12 was associated with HRQL improvement regardless of regimen (up to +2.9 points, P <.05). The use of IFN-free treatment was a consistent independent predictor of higher HRQL scores during treatment (β: +2.1 to +10.7 points, P <.02). Conclusions: East Asian HCV patients treated with an IFN-free regimen had better on-treatment HRQL scores. These data should inform policymakers about the comprehensive benefits of IFN-free regimens in East Asian patients with HCV.

Original languageEnglish
Pages (from-to)1179-1187
Number of pages9
JournalLiver International
Volume38
Issue number7
DOIs
Publication statusPublished - 2018 Jul

All Science Journal Classification (ASJC) codes

  • Hepatology

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    Younossi, Z. M., Stepanova, M., Henry, L., Han, K. H., Ahn, S. H., Lim, Y. S., Chuang, W. L., Kao, J. H., Kinh, N., Lai, C. L., Yuen, M. F., Chan, H. L. Y., & Lai, W. (2018). The effect of interferon-free regimens on health-related quality of life in East Asian patients with chronic hepatitis C. Liver International, 38(7), 1179-1187. https://doi.org/10.1111/liv.13650