The effect of intracoronary nicorandil on coronary myocardial bridging

Jae Hun Jung, Pil Ki Min, Chong Won Sung, Sang Hak Lee, Seonghoon Choi, Jung Rae Cho, Namho Lee, Kyoung Ha Park, Min Kyu Kim, Woo Jung Park, Yangsoo Jang

Research output: Contribution to journalArticle

Abstract

Medical treatments of coronary myocardial bridging (CMB) generally include ?2-blockers and calcium channel blockers. Nitrates are avoided because symptoms may worsen. Nicorandil is a hybrid of a nitrate and a potassium channel opener. However, the effect of nicorandil on CMB is unknown. We analyzed nicorandil reactivity at the site with CMB in 51 patients. Maximal and minimal diameters of CMB were measured by quantitative angiography at baseline and at 60 seconds after intracoronary administration of 200 mg nicorandil. The maximal diameter during diastole increased from 2.15 + 0.42 mm to 2.34 + 0.44 mm after administration of nicorandil (P <.001), and the minimal diameter during systole increased from 1.24 + 0.63 mm to 1.67 + 0.64 mm (P <.001). Thus, nicorandil reduced the percentage vessel narrowing from 44.0 + 26.1% to 30.3 + 21.2% (P <.001). In 22 patients, we also evaluated the effect of nitroglycerin. The maximal diameter during diastole increased from 2.25 + 0.47 mm to 2.51 + 0.44 mm after administration of nitroglycerin (P <.019), and the minimal diameter during systole decreased from 1.28 + 0.64 mm to 1.14 + 0.60 mm (P =.276). Thus, nitroglycerin augmented the percentage vessel narrowing from 44.9% + 25.0% to 56.0% + 23.5% (P =.023). These results indicate that intracoronary administration of nicorandil could dilate coronary arteries during diastole as well as systole in patients with CMB during coronary angiography.

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume14
Issue number3
DOIs
Publication statusPublished - 2009 Sep 1

Fingerprint

Myocardial Bridging
Nicorandil
Diastole
Systole
Nitroglycerin
Nitrates
Potassium Channels
Calcium Channel Blockers
Coronary Angiography
Coronary Vessels
Angiography

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Jung, Jae Hun ; Min, Pil Ki ; Sung, Chong Won ; Lee, Sang Hak ; Choi, Seonghoon ; Cho, Jung Rae ; Lee, Namho ; Park, Kyoung Ha ; Kim, Min Kyu ; Park, Woo Jung ; Jang, Yangsoo. / The effect of intracoronary nicorandil on coronary myocardial bridging. In: Journal of Cardiovascular Pharmacology and Therapeutics. 2009 ; Vol. 14, No. 3. pp. 180-184.
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title = "The effect of intracoronary nicorandil on coronary myocardial bridging",
abstract = "Medical treatments of coronary myocardial bridging (CMB) generally include ?2-blockers and calcium channel blockers. Nitrates are avoided because symptoms may worsen. Nicorandil is a hybrid of a nitrate and a potassium channel opener. However, the effect of nicorandil on CMB is unknown. We analyzed nicorandil reactivity at the site with CMB in 51 patients. Maximal and minimal diameters of CMB were measured by quantitative angiography at baseline and at 60 seconds after intracoronary administration of 200 mg nicorandil. The maximal diameter during diastole increased from 2.15 + 0.42 mm to 2.34 + 0.44 mm after administration of nicorandil (P <.001), and the minimal diameter during systole increased from 1.24 + 0.63 mm to 1.67 + 0.64 mm (P <.001). Thus, nicorandil reduced the percentage vessel narrowing from 44.0 + 26.1{\%} to 30.3 + 21.2{\%} (P <.001). In 22 patients, we also evaluated the effect of nitroglycerin. The maximal diameter during diastole increased from 2.25 + 0.47 mm to 2.51 + 0.44 mm after administration of nitroglycerin (P <.019), and the minimal diameter during systole decreased from 1.28 + 0.64 mm to 1.14 + 0.60 mm (P =.276). Thus, nitroglycerin augmented the percentage vessel narrowing from 44.9{\%} + 25.0{\%} to 56.0{\%} + 23.5{\%} (P =.023). These results indicate that intracoronary administration of nicorandil could dilate coronary arteries during diastole as well as systole in patients with CMB during coronary angiography.",
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Jung, JH, Min, PK, Sung, CW, Lee, SH, Choi, S, Cho, JR, Lee, N, Park, KH, Kim, MK, Park, WJ & Jang, Y 2009, 'The effect of intracoronary nicorandil on coronary myocardial bridging', Journal of Cardiovascular Pharmacology and Therapeutics, vol. 14, no. 3, pp. 180-184. https://doi.org/10.1177/1074248409338930

The effect of intracoronary nicorandil on coronary myocardial bridging. / Jung, Jae Hun; Min, Pil Ki; Sung, Chong Won; Lee, Sang Hak; Choi, Seonghoon; Cho, Jung Rae; Lee, Namho; Park, Kyoung Ha; Kim, Min Kyu; Park, Woo Jung; Jang, Yangsoo.

In: Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 14, No. 3, 01.09.2009, p. 180-184.

Research output: Contribution to journalArticle

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T1 - The effect of intracoronary nicorandil on coronary myocardial bridging

AU - Jung, Jae Hun

AU - Min, Pil Ki

AU - Sung, Chong Won

AU - Lee, Sang Hak

AU - Choi, Seonghoon

AU - Cho, Jung Rae

AU - Lee, Namho

AU - Park, Kyoung Ha

AU - Kim, Min Kyu

AU - Park, Woo Jung

AU - Jang, Yangsoo

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Y1 - 2009/9/1

N2 - Medical treatments of coronary myocardial bridging (CMB) generally include ?2-blockers and calcium channel blockers. Nitrates are avoided because symptoms may worsen. Nicorandil is a hybrid of a nitrate and a potassium channel opener. However, the effect of nicorandil on CMB is unknown. We analyzed nicorandil reactivity at the site with CMB in 51 patients. Maximal and minimal diameters of CMB were measured by quantitative angiography at baseline and at 60 seconds after intracoronary administration of 200 mg nicorandil. The maximal diameter during diastole increased from 2.15 + 0.42 mm to 2.34 + 0.44 mm after administration of nicorandil (P <.001), and the minimal diameter during systole increased from 1.24 + 0.63 mm to 1.67 + 0.64 mm (P <.001). Thus, nicorandil reduced the percentage vessel narrowing from 44.0 + 26.1% to 30.3 + 21.2% (P <.001). In 22 patients, we also evaluated the effect of nitroglycerin. The maximal diameter during diastole increased from 2.25 + 0.47 mm to 2.51 + 0.44 mm after administration of nitroglycerin (P <.019), and the minimal diameter during systole decreased from 1.28 + 0.64 mm to 1.14 + 0.60 mm (P =.276). Thus, nitroglycerin augmented the percentage vessel narrowing from 44.9% + 25.0% to 56.0% + 23.5% (P =.023). These results indicate that intracoronary administration of nicorandil could dilate coronary arteries during diastole as well as systole in patients with CMB during coronary angiography.

AB - Medical treatments of coronary myocardial bridging (CMB) generally include ?2-blockers and calcium channel blockers. Nitrates are avoided because symptoms may worsen. Nicorandil is a hybrid of a nitrate and a potassium channel opener. However, the effect of nicorandil on CMB is unknown. We analyzed nicorandil reactivity at the site with CMB in 51 patients. Maximal and minimal diameters of CMB were measured by quantitative angiography at baseline and at 60 seconds after intracoronary administration of 200 mg nicorandil. The maximal diameter during diastole increased from 2.15 + 0.42 mm to 2.34 + 0.44 mm after administration of nicorandil (P <.001), and the minimal diameter during systole increased from 1.24 + 0.63 mm to 1.67 + 0.64 mm (P <.001). Thus, nicorandil reduced the percentage vessel narrowing from 44.0 + 26.1% to 30.3 + 21.2% (P <.001). In 22 patients, we also evaluated the effect of nitroglycerin. The maximal diameter during diastole increased from 2.25 + 0.47 mm to 2.51 + 0.44 mm after administration of nitroglycerin (P <.019), and the minimal diameter during systole decreased from 1.28 + 0.64 mm to 1.14 + 0.60 mm (P =.276). Thus, nitroglycerin augmented the percentage vessel narrowing from 44.9% + 25.0% to 56.0% + 23.5% (P =.023). These results indicate that intracoronary administration of nicorandil could dilate coronary arteries during diastole as well as systole in patients with CMB during coronary angiography.

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