The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease: Serial transcranial Doppler studies

Seok Woo Yong, Kyung Yul Lee, philhyu Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Levodopa treatment in patients with Parkinson's disease (PD) is known to cause elevation in serum homocysteine levels. We investigated whether this increase in homocysteine level influences cerebral vascular flow velocity and resistance using transcranial Doppler (TCD). This study included 17 patients with de novo PD. Homocysteine levels and TCD parameters at middle cerebral artery were investigated before and after 3 months of levodopa treatment. Correlation analyses were done between changes in homocysteine levels and TCD parameters. After 3 months of levodopa treatment, homocysteine level increased significantly from 13.3mg/dL to 17.0 mg/dL (p < 0.001), but there were no meaningful changes in mean velocity (MV) and pulsatility index (PI). Correlation analysis revealed that the changes in homocysteine level had negative correlation with MV (r = -0.53, p = 0.027) and positive correlation with PI (r = 0.55, p = 0.028). Our study infer that although short-term treatment of levodopa itself does not cause overall alteration of cerebral blood flow velocities and resistances, patients who has greater degree of increased homocysteine level may still be at a risk of developing cerebral vascular stiffness.

Original languageEnglish
Pages (from-to)225-227
Number of pages3
JournalParkinsonism and Related Disorders
Volume16
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

Fingerprint

Levodopa
Homocysteine
Parkinson Disease
Hemodynamics
Therapeutics
Cerebrovascular Circulation
Vascular Stiffness
Blood Flow Velocity
Middle Cerebral Artery
Vascular Resistance
Serum

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

@article{e0cffec6166345e48de37a6000b6fcc6,
title = "The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease: Serial transcranial Doppler studies",
abstract = "Levodopa treatment in patients with Parkinson's disease (PD) is known to cause elevation in serum homocysteine levels. We investigated whether this increase in homocysteine level influences cerebral vascular flow velocity and resistance using transcranial Doppler (TCD). This study included 17 patients with de novo PD. Homocysteine levels and TCD parameters at middle cerebral artery were investigated before and after 3 months of levodopa treatment. Correlation analyses were done between changes in homocysteine levels and TCD parameters. After 3 months of levodopa treatment, homocysteine level increased significantly from 13.3mg/dL to 17.0 mg/dL (p < 0.001), but there were no meaningful changes in mean velocity (MV) and pulsatility index (PI). Correlation analysis revealed that the changes in homocysteine level had negative correlation with MV (r = -0.53, p = 0.027) and positive correlation with PI (r = 0.55, p = 0.028). Our study infer that although short-term treatment of levodopa itself does not cause overall alteration of cerebral blood flow velocities and resistances, patients who has greater degree of increased homocysteine level may still be at a risk of developing cerebral vascular stiffness.",
author = "Yong, {Seok Woo} and Lee, {Kyung Yul} and philhyu Lee",
year = "2010",
month = "3",
day = "1",
doi = "10.1016/j.parkreldis.2009.09.003",
language = "English",
volume = "16",
pages = "225--227",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "3",

}

The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease : Serial transcranial Doppler studies. / Yong, Seok Woo; Lee, Kyung Yul; Lee, philhyu.

In: Parkinsonism and Related Disorders, Vol. 16, No. 3, 01.03.2010, p. 225-227.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease

T2 - Serial transcranial Doppler studies

AU - Yong, Seok Woo

AU - Lee, Kyung Yul

AU - Lee, philhyu

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Levodopa treatment in patients with Parkinson's disease (PD) is known to cause elevation in serum homocysteine levels. We investigated whether this increase in homocysteine level influences cerebral vascular flow velocity and resistance using transcranial Doppler (TCD). This study included 17 patients with de novo PD. Homocysteine levels and TCD parameters at middle cerebral artery were investigated before and after 3 months of levodopa treatment. Correlation analyses were done between changes in homocysteine levels and TCD parameters. After 3 months of levodopa treatment, homocysteine level increased significantly from 13.3mg/dL to 17.0 mg/dL (p < 0.001), but there were no meaningful changes in mean velocity (MV) and pulsatility index (PI). Correlation analysis revealed that the changes in homocysteine level had negative correlation with MV (r = -0.53, p = 0.027) and positive correlation with PI (r = 0.55, p = 0.028). Our study infer that although short-term treatment of levodopa itself does not cause overall alteration of cerebral blood flow velocities and resistances, patients who has greater degree of increased homocysteine level may still be at a risk of developing cerebral vascular stiffness.

AB - Levodopa treatment in patients with Parkinson's disease (PD) is known to cause elevation in serum homocysteine levels. We investigated whether this increase in homocysteine level influences cerebral vascular flow velocity and resistance using transcranial Doppler (TCD). This study included 17 patients with de novo PD. Homocysteine levels and TCD parameters at middle cerebral artery were investigated before and after 3 months of levodopa treatment. Correlation analyses were done between changes in homocysteine levels and TCD parameters. After 3 months of levodopa treatment, homocysteine level increased significantly from 13.3mg/dL to 17.0 mg/dL (p < 0.001), but there were no meaningful changes in mean velocity (MV) and pulsatility index (PI). Correlation analysis revealed that the changes in homocysteine level had negative correlation with MV (r = -0.53, p = 0.027) and positive correlation with PI (r = 0.55, p = 0.028). Our study infer that although short-term treatment of levodopa itself does not cause overall alteration of cerebral blood flow velocities and resistances, patients who has greater degree of increased homocysteine level may still be at a risk of developing cerebral vascular stiffness.

UR - http://www.scopus.com/inward/record.url?scp=76849116783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76849116783&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2009.09.003

DO - 10.1016/j.parkreldis.2009.09.003

M3 - Article

C2 - 19815447

AN - SCOPUS:76849116783

VL - 16

SP - 225

EP - 227

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

IS - 3

ER -