The effect of Micro-current electrical stimulation on muscle atrophy caused by sciatic nerve compression

Seohyun Kim, Donghyun Hwang, Hana Lee, Han Sung Kim, Seungkwan Cho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of the present study was to evaluate the effect of micro-current stimulation on muscle atrophy caused by sciatic nerve compression. To investigate the effects of micro-current stimulation on muscle atrophy, thirty 5-week-old Sprague Dawley rat were used and assigned to three groups including the control group (CON, n=10), the Sciatic Nerve Injury group (SNI, n=10), the Sciatic Nerve Injury and treated with Micro-current Electrical stimulation group (SNI+MET, n=10). All of the animals in SNI+MET received 50uA of micro-current electrical stimulation for 4 weeks while animals in SNI received no stimulation. In order to measure the changes of the muscle volume and assess biological mechanism of muscle regeneration for 4 weeks, In-vivo Micro-CT and Western Blot data were analyzed. As a result, in the case of Micro-CT analysis, the SNI and SNI+MET groups compared to the CON group showed a significant decrease in the muscle volume after 2 weeks, confirming the atrophy caused by the sciatic nerve compression. However, there was no significant difference between SNI and SNI+MET group after applying 4 weeks of micro-current electrical stimulation. In conclusion, further research needs to consider the micro-current stimulation intensity of 50μ A revealed through the present study, and the biological mechanism of nerve regeneration should be also identified based on the relationship between nerve injury and muscle atrophy.

Original languageEnglish
Title of host publicationICEIC 2019 - International Conference on Electronics, Information, and Communication
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9788995004449
DOIs
Publication statusPublished - 2019 May 3
Event18th International Conference on Electronics, Information, and Communication, ICEIC 2019 - Auckland, New Zealand
Duration: 2019 Jan 222019 Jan 25

Publication series

NameICEIC 2019 - International Conference on Electronics, Information, and Communication

Conference

Conference18th International Conference on Electronics, Information, and Communication, ICEIC 2019
CountryNew Zealand
CityAuckland
Period19/1/2219/1/25

Bibliographical note

Funding Information:
This work was supported (in part) by Medium and large complex technology commercialization project supported by the Ministry of Science and Technology, Ministry of Information and Communication and the Korea Research Foundation

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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