The purpose of the present study was to evaluate the effect of micro-current stimulation on muscle atrophy caused by sciatic nerve compression. To investigate the effects of micro-current stimulation on muscle atrophy, thirty 5-week-old Sprague Dawley rat were used and assigned to three groups including the control group (CON, n=10), the Sciatic Nerve Injury group (SNI, n=10), the Sciatic Nerve Injury and treated with Micro-current Electrical stimulation group (SNI+MET, n=10). All of the animals in SNI+MET received 50uA of micro-current electrical stimulation for 4 weeks while animals in SNI received no stimulation. In order to measure the changes of the muscle volume and assess biological mechanism of muscle regeneration for 4 weeks, In-vivo Micro-CT and Western Blot data were analyzed. As a result, in the case of Micro-CT analysis, the SNI and SNI+MET groups compared to the CON group showed a significant decrease in the muscle volume after 2 weeks, confirming the atrophy caused by the sciatic nerve compression. However, there was no significant difference between SNI and SNI+MET group after applying 4 weeks of micro-current electrical stimulation. In conclusion, further research needs to consider the micro-current stimulation intensity of 50μ A revealed through the present study, and the biological mechanism of nerve regeneration should be also identified based on the relationship between nerve injury and muscle atrophy.
|Title of host publication||ICEIC 2019 - International Conference on Electronics, Information, and Communication|
|Publisher||Institute of Electrical and Electronics Engineers Inc.|
|Publication status||Published - 2019 May 3|
|Event||18th International Conference on Electronics, Information, and Communication, ICEIC 2019 - Auckland, New Zealand|
Duration: 2019 Jan 22 → 2019 Jan 25
|Name||ICEIC 2019 - International Conference on Electronics, Information, and Communication|
|Conference||18th International Conference on Electronics, Information, and Communication, ICEIC 2019|
|Period||19/1/22 → 19/1/25|
Bibliographical noteFunding Information:
This work was supported (in part) by Medium and large complex technology commercialization project supported by the Ministry of Science and Technology, Ministry of Information and Communication and the Korea Research Foundation
© 2019 Institute of Electronics and Information Engineers (IEIE).
All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
- Electrical and Electronic Engineering