The effect of microbubble concentration on thresholds for tissue damage produced by single bursts of high intensity ultrasound during continuous Optison® infusion

Binh C. Tran, Jongbum Seo, J. Brian Fowlkes, Charles A. Cain

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

The presence of ultrasound contrast agent (stabilized microbubbles) during high intensity focused ultrasound insonation can reduce both the exposure intensity and duration required for producing macroscopic tissue damage. In this paper, we evaluate the enhancement produced by Optison® infusion at concentrations of 0, 0.1, 0.3, 1, 3, and 10 μL/kg/min. Acute canine kidneys were surgically externalized and insonified with single ultrasound exposures. The probability of tissue damage production was determined with respect to exposure intensity and duration for each concentration. As microbubble concentration increased from 0 to 10 μL/kg/min, the requisite intensity and the requisite duration both gradually decreased. The results indicate that microbubble introduction up to 10 μL/kg/min is effective for aiding ultrasound therapy.

Original languageEnglish
Pages (from-to)1411-1414
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Volume2
Publication statusPublished - 2002 Dec 1
Event2002 IEEE Ultrasonics Symposium - Munich, Germany
Duration: 2002 Oct 82002 Oct 11

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bursts
Ultrasonics
Tissue
damage
thresholds
kidneys
therapy
augmentation

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

Cite this

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title = "The effect of microbubble concentration on thresholds for tissue damage produced by single bursts of high intensity ultrasound during continuous Optison{\circledR} infusion",
abstract = "The presence of ultrasound contrast agent (stabilized microbubbles) during high intensity focused ultrasound insonation can reduce both the exposure intensity and duration required for producing macroscopic tissue damage. In this paper, we evaluate the enhancement produced by Optison{\circledR} infusion at concentrations of 0, 0.1, 0.3, 1, 3, and 10 μL/kg/min. Acute canine kidneys were surgically externalized and insonified with single ultrasound exposures. The probability of tissue damage production was determined with respect to exposure intensity and duration for each concentration. As microbubble concentration increased from 0 to 10 μL/kg/min, the requisite intensity and the requisite duration both gradually decreased. The results indicate that microbubble introduction up to 10 μL/kg/min is effective for aiding ultrasound therapy.",
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The effect of microbubble concentration on thresholds for tissue damage produced by single bursts of high intensity ultrasound during continuous Optison® infusion. / Tran, Binh C.; Seo, Jongbum; Fowlkes, J. Brian; Cain, Charles A.

In: Proceedings of the IEEE Ultrasonics Symposium, Vol. 2, 01.12.2002, p. 1411-1414.

Research output: Contribution to journalConference article

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T1 - The effect of microbubble concentration on thresholds for tissue damage produced by single bursts of high intensity ultrasound during continuous Optison® infusion

AU - Tran, Binh C.

AU - Seo, Jongbum

AU - Fowlkes, J. Brian

AU - Cain, Charles A.

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N2 - The presence of ultrasound contrast agent (stabilized microbubbles) during high intensity focused ultrasound insonation can reduce both the exposure intensity and duration required for producing macroscopic tissue damage. In this paper, we evaluate the enhancement produced by Optison® infusion at concentrations of 0, 0.1, 0.3, 1, 3, and 10 μL/kg/min. Acute canine kidneys were surgically externalized and insonified with single ultrasound exposures. The probability of tissue damage production was determined with respect to exposure intensity and duration for each concentration. As microbubble concentration increased from 0 to 10 μL/kg/min, the requisite intensity and the requisite duration both gradually decreased. The results indicate that microbubble introduction up to 10 μL/kg/min is effective for aiding ultrasound therapy.

AB - The presence of ultrasound contrast agent (stabilized microbubbles) during high intensity focused ultrasound insonation can reduce both the exposure intensity and duration required for producing macroscopic tissue damage. In this paper, we evaluate the enhancement produced by Optison® infusion at concentrations of 0, 0.1, 0.3, 1, 3, and 10 μL/kg/min. Acute canine kidneys were surgically externalized and insonified with single ultrasound exposures. The probability of tissue damage production was determined with respect to exposure intensity and duration for each concentration. As microbubble concentration increased from 0 to 10 μL/kg/min, the requisite intensity and the requisite duration both gradually decreased. The results indicate that microbubble introduction up to 10 μL/kg/min is effective for aiding ultrasound therapy.

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