The effect of MMP-13, MMP-12, and AMBN on gingival enlargement and root deformation in a new type of gingival fibromatosis

Chung Min Kang, Jae Ho Lee, Mijeong Jeon, JeSeon Song, Seong Oh Kim

Research output: Contribution to journalArticle

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Abstract

This case compared gene-expression between a new type of idiopathic gingival fibromatosis (IGF) and normal gingiva, to clarify the nature of the gingival overgrowth and dental anomaly. A 6-year-old girl with generalized gingival overgrowth and root deformations was diagnosed with IGF. Gene expression profiles were compared between normal gingiva (N=9) and one IGF gingiva using cDNA microarray. Genes related to regulation of cell proliferation and proteolytic degradation were expressed strongly in IGF. MMP-13 and MMP-12 expression were 120 times and 96 times lower in IGF, respectively, whereas AMBN expression was 79 times higher. RT-PCR and immunohistochemical staining supported the microarray results. Reduced proteolytic activity due to low MMP-13 and MMP-12 expression appears to be a potential mechanism for gingival overgrowth. Genetic investigations, such as expression levels of MMP-13, MMP-12, and AMBN, may enable classification of a new syndrome characterized by gingival enlargement with abnormal root development.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalJournal of Clinical Pediatric Dentistry
Volume42
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Gingival Fibromatosis
Matrix Metalloproteinases
Gingival Overgrowth
Gingiva
Oligonucleotide Array Sequence Analysis
Transcriptome
Tooth
Cell Proliferation
Staining and Labeling
Gene Expression
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Dentistry(all)

Cite this

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abstract = "This case compared gene-expression between a new type of idiopathic gingival fibromatosis (IGF) and normal gingiva, to clarify the nature of the gingival overgrowth and dental anomaly. A 6-year-old girl with generalized gingival overgrowth and root deformations was diagnosed with IGF. Gene expression profiles were compared between normal gingiva (N=9) and one IGF gingiva using cDNA microarray. Genes related to regulation of cell proliferation and proteolytic degradation were expressed strongly in IGF. MMP-13 and MMP-12 expression were 120 times and 96 times lower in IGF, respectively, whereas AMBN expression was 79 times higher. RT-PCR and immunohistochemical staining supported the microarray results. Reduced proteolytic activity due to low MMP-13 and MMP-12 expression appears to be a potential mechanism for gingival overgrowth. Genetic investigations, such as expression levels of MMP-13, MMP-12, and AMBN, may enable classification of a new syndrome characterized by gingival enlargement with abnormal root development.",
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The effect of MMP-13, MMP-12, and AMBN on gingival enlargement and root deformation in a new type of gingival fibromatosis. / Kang, Chung Min; Lee, Jae Ho; Jeon, Mijeong; Song, JeSeon; Kim, Seong Oh.

In: Journal of Clinical Pediatric Dentistry, Vol. 42, No. 1, 01.01.2018, p. 50-54.

Research output: Contribution to journalArticle

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