The effect of neonatal hypothyroidism and low family income on intellectual disability: A population-based cohort study

Jin Young Nam, Young Choi, Mo Kyung Jung, Jaeyong Shin, Kyoung Hee Cho, Woorim Kim, Euncheol Park

Research output: Contribution to journalArticle

Abstract

Background To investigate relationships among neonatal hypothyroidism, family income, and intellectual disability, as well as the combined effects of neonatal hypothyroidism and low family income on intellectual disability. Methods Data were extracted from the National Health Insurance Service-National Sample Cohort from 2002 to 2011. This retrospective study included 91,247 infants. The presence of intellectual disability was based on the disability evaluation system in Korea. Newborn hypothyroidism was identified from diagnosis and prescription codes. Family income was determined from average monthly insurance premiums. Cox proportional hazards models were used to calculate adjusted hazard ratios. Results Of the 91,247 infants, 208 were considered to have intellectual disability (29.18 cases per 100,000 person-year). The risk of intellectual disability was higher in infants with hypothyroidism than in those without hypothyroidism (hazard ratio = 5.28, P: < .0001). The risk of intellectual disability was higher in infants with low family income than in those with high family income (hazard ratio = 2.32, P: < .0001). The risk of intellectual disability was higher in infants with hypothyroidism and low family income than in those without hypothyroidism and with high family income (hazard ratio = 36.05, P: < .0001). Conclusions Neonatal hypothyroidism and low family income were associated with the risk of intellectual disability in Korea. Additionally, neonatal hypothyroidism and low family income significantly increased the risk of intellectual disability. Public health policymakers should consider providing additional resources for alleviating neonatal hypothyroidism among low-income families.

Original languageEnglish
Article numbere0205955
JournalPloS one
Volume13
Issue number11
DOIs
Publication statusPublished - 2018 Nov 1

Fingerprint

low income households
hypothyroidism
Hypothyroidism
cohort studies
Intellectual Disability
Hazards
Cohort Studies
Population
household income
Health insurance
National Health Programs
Insurance
Public health
Korea
Korean Peninsula
Disability Evaluation
health insurance
insurance
Proportional Hazards Models
retrospective studies

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Nam, Jin Young ; Choi, Young ; Jung, Mo Kyung ; Shin, Jaeyong ; Cho, Kyoung Hee ; Kim, Woorim ; Park, Euncheol. / The effect of neonatal hypothyroidism and low family income on intellectual disability : A population-based cohort study. In: PloS one. 2018 ; Vol. 13, No. 11.
@article{3ec8bffe08584b1abaddb566864cf515,
title = "The effect of neonatal hypothyroidism and low family income on intellectual disability: A population-based cohort study",
abstract = "Background To investigate relationships among neonatal hypothyroidism, family income, and intellectual disability, as well as the combined effects of neonatal hypothyroidism and low family income on intellectual disability. Methods Data were extracted from the National Health Insurance Service-National Sample Cohort from 2002 to 2011. This retrospective study included 91,247 infants. The presence of intellectual disability was based on the disability evaluation system in Korea. Newborn hypothyroidism was identified from diagnosis and prescription codes. Family income was determined from average monthly insurance premiums. Cox proportional hazards models were used to calculate adjusted hazard ratios. Results Of the 91,247 infants, 208 were considered to have intellectual disability (29.18 cases per 100,000 person-year). The risk of intellectual disability was higher in infants with hypothyroidism than in those without hypothyroidism (hazard ratio = 5.28, P: < .0001). The risk of intellectual disability was higher in infants with low family income than in those with high family income (hazard ratio = 2.32, P: < .0001). The risk of intellectual disability was higher in infants with hypothyroidism and low family income than in those without hypothyroidism and with high family income (hazard ratio = 36.05, P: < .0001). Conclusions Neonatal hypothyroidism and low family income were associated with the risk of intellectual disability in Korea. Additionally, neonatal hypothyroidism and low family income significantly increased the risk of intellectual disability. Public health policymakers should consider providing additional resources for alleviating neonatal hypothyroidism among low-income families.",
author = "Nam, {Jin Young} and Young Choi and Jung, {Mo Kyung} and Jaeyong Shin and Cho, {Kyoung Hee} and Woorim Kim and Euncheol Park",
year = "2018",
month = "11",
day = "1",
doi = "10.1371/journal.pone.0205955",
language = "English",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

The effect of neonatal hypothyroidism and low family income on intellectual disability : A population-based cohort study. / Nam, Jin Young; Choi, Young; Jung, Mo Kyung; Shin, Jaeyong; Cho, Kyoung Hee; Kim, Woorim; Park, Euncheol.

In: PloS one, Vol. 13, No. 11, e0205955, 01.11.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of neonatal hypothyroidism and low family income on intellectual disability

T2 - A population-based cohort study

AU - Nam, Jin Young

AU - Choi, Young

AU - Jung, Mo Kyung

AU - Shin, Jaeyong

AU - Cho, Kyoung Hee

AU - Kim, Woorim

AU - Park, Euncheol

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background To investigate relationships among neonatal hypothyroidism, family income, and intellectual disability, as well as the combined effects of neonatal hypothyroidism and low family income on intellectual disability. Methods Data were extracted from the National Health Insurance Service-National Sample Cohort from 2002 to 2011. This retrospective study included 91,247 infants. The presence of intellectual disability was based on the disability evaluation system in Korea. Newborn hypothyroidism was identified from diagnosis and prescription codes. Family income was determined from average monthly insurance premiums. Cox proportional hazards models were used to calculate adjusted hazard ratios. Results Of the 91,247 infants, 208 were considered to have intellectual disability (29.18 cases per 100,000 person-year). The risk of intellectual disability was higher in infants with hypothyroidism than in those without hypothyroidism (hazard ratio = 5.28, P: < .0001). The risk of intellectual disability was higher in infants with low family income than in those with high family income (hazard ratio = 2.32, P: < .0001). The risk of intellectual disability was higher in infants with hypothyroidism and low family income than in those without hypothyroidism and with high family income (hazard ratio = 36.05, P: < .0001). Conclusions Neonatal hypothyroidism and low family income were associated with the risk of intellectual disability in Korea. Additionally, neonatal hypothyroidism and low family income significantly increased the risk of intellectual disability. Public health policymakers should consider providing additional resources for alleviating neonatal hypothyroidism among low-income families.

AB - Background To investigate relationships among neonatal hypothyroidism, family income, and intellectual disability, as well as the combined effects of neonatal hypothyroidism and low family income on intellectual disability. Methods Data were extracted from the National Health Insurance Service-National Sample Cohort from 2002 to 2011. This retrospective study included 91,247 infants. The presence of intellectual disability was based on the disability evaluation system in Korea. Newborn hypothyroidism was identified from diagnosis and prescription codes. Family income was determined from average monthly insurance premiums. Cox proportional hazards models were used to calculate adjusted hazard ratios. Results Of the 91,247 infants, 208 were considered to have intellectual disability (29.18 cases per 100,000 person-year). The risk of intellectual disability was higher in infants with hypothyroidism than in those without hypothyroidism (hazard ratio = 5.28, P: < .0001). The risk of intellectual disability was higher in infants with low family income than in those with high family income (hazard ratio = 2.32, P: < .0001). The risk of intellectual disability was higher in infants with hypothyroidism and low family income than in those without hypothyroidism and with high family income (hazard ratio = 36.05, P: < .0001). Conclusions Neonatal hypothyroidism and low family income were associated with the risk of intellectual disability in Korea. Additionally, neonatal hypothyroidism and low family income significantly increased the risk of intellectual disability. Public health policymakers should consider providing additional resources for alleviating neonatal hypothyroidism among low-income families.

UR - http://www.scopus.com/inward/record.url?scp=85056361919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056361919&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0205955

DO - 10.1371/journal.pone.0205955

M3 - Article

C2 - 30403688

AN - SCOPUS:85056361919

VL - 13

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 11

M1 - e0205955

ER -