The effect of nucleus basalis magnocellularis deep brain stimulation on memory function in a rat model of dementia

Ji Eun Lee, Da Un Jeong, Jihyeon Lee, Won Seok Chang, Jin Woo Chang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Deep brain stimulation has recently been considered a potential therapy in improving memory function. It has been shown that a change of neurotransmitters has an effect on memory function. However, much about the exact underlying neural mechanism is not yet completely understood. We therefore examined changes in neurotransmitter systems and spatial memory caused by stimulation of nucleus basalis magnocellularis in a rat model of dementia. Methods: We divided rats into four groups: Normal, Lesion, Implantation, and Stimulation. We used 192 IgG-saporin for degeneration of basal forebrain cholinergic neuron related with learning and memory and it was injected into all rats except for the normal group. An electrode was ipsilaterally inserted in the nucleus basalis magnocellularis of all rats of the implantation and stimulation group, and the stimulation group received the electrical stimulation. Features were verified by the Morris water maze, immunochemistry and western blotting. Results: All groups showed similar performances during Morris water maze training. During the probe trial, performance of the lesion and implantation group decreased. However, the stimulation group showed an equivalent performance to the normal group. In the lesion and implantation group, expression of glutamate acid decarboxylase65&67 decreased in the medial prefrontal cortex and expression of glutamate transporters increased in the medial prefrontal cortex and hippocampus. However, expression of the stimulation group showed similar levels as the normal group. Conclusion: The results suggest that nucleus basalis magnocellularis stimulation enhances consolidation and retrieval of visuospatial memory related to changes of glutamate acid decarboxylase65&67 and glutamate transporter.

Original languageEnglish
Article number6
JournalBMC neurology
Volume16
Issue number1
DOIs
Publication statusPublished - 2016 Jan 12

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Basal Nucleus of Meynert
Deep Brain Stimulation
Dementia
Amino Acid Transport System X-AG
Prefrontal Cortex
Neurotransmitter Agents
Glutamic Acid
Immunochemistry
Cholinergic Neurons
Acids
Water
Electric Stimulation
Hippocampus
Electrodes
Western Blotting
Learning

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

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abstract = "Background: Deep brain stimulation has recently been considered a potential therapy in improving memory function. It has been shown that a change of neurotransmitters has an effect on memory function. However, much about the exact underlying neural mechanism is not yet completely understood. We therefore examined changes in neurotransmitter systems and spatial memory caused by stimulation of nucleus basalis magnocellularis in a rat model of dementia. Methods: We divided rats into four groups: Normal, Lesion, Implantation, and Stimulation. We used 192 IgG-saporin for degeneration of basal forebrain cholinergic neuron related with learning and memory and it was injected into all rats except for the normal group. An electrode was ipsilaterally inserted in the nucleus basalis magnocellularis of all rats of the implantation and stimulation group, and the stimulation group received the electrical stimulation. Features were verified by the Morris water maze, immunochemistry and western blotting. Results: All groups showed similar performances during Morris water maze training. During the probe trial, performance of the lesion and implantation group decreased. However, the stimulation group showed an equivalent performance to the normal group. In the lesion and implantation group, expression of glutamate acid decarboxylase65&67 decreased in the medial prefrontal cortex and expression of glutamate transporters increased in the medial prefrontal cortex and hippocampus. However, expression of the stimulation group showed similar levels as the normal group. Conclusion: The results suggest that nucleus basalis magnocellularis stimulation enhances consolidation and retrieval of visuospatial memory related to changes of glutamate acid decarboxylase65&67 and glutamate transporter.",
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The effect of nucleus basalis magnocellularis deep brain stimulation on memory function in a rat model of dementia. / Lee, Ji Eun; Jeong, Da Un; Lee, Jihyeon; Chang, Won Seok; Chang, Jin Woo.

In: BMC neurology, Vol. 16, No. 1, 6, 12.01.2016.

Research output: Contribution to journalArticle

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