The Effect of Omega,3 Enriched Oral Nutrition Supplement on Nutritional Indices and Quality of Life in Gastrointestinal Cancer Patients: A Randomized Clinical Trial

Eunbo Sim, Jin Min Kim, Seung Min Lee, Moon Jae Chung, Si Young Song, Eun Sun Kim, Hoon Jai Chun, Mi Kyung Sung

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1 Citation (Scopus)


Objective: Gastrointestinal (GI) cancer patients often experience severe malnutrition during cancer therapies due to gastrointestinal dysfunctions including poor digestion and absorption as well as tumor-associated anorexia. In this study, we performed a randomized clinical trial to determine the efficacy of oral nutrition supplement (ONS) enriched with omega-3 fatty acids on nutritional status, quality of life (QOL), and pro-inflammatory indices. Methods: Patients diagnosed with GI cancers were recruited and screened for eligibility. A total of 58 patients were randomly allocated to either the control group (n=27) or the experimental group (n=31). The intervention group received 200 ml ONS twice a day while the control group received routine care. Anthropometrics, Patient-Generated Subjective Global Assessment (PG,SGA) score, QOL score and nutrient intake data were collected at baseline, week 4 and week 8. Blood was drawn for biochemical assessments. Nine patients from each group dropped out of the study Forty patients (18 control patients and 22 intervention patients) completed the study. Results: This study showed that ONS intervention improved PG-SGA scores in the intervention group (p<0.01). Scores of physical functioning score and role functioning were declined only in the control group and the difference between week 8 and baseline for role functioning was significant (p<0.001). Fatigue score was steadily decreased in the experiment group, and the differences between week 8 and baseline was significant between two groups (p<0.02). However, no statistically significant improvement in biochemical markers of nutritional status and pro-inflammatory cytokine concentrations were found. These results suggests that ONS intervention for 8 weeks improves PG,SGA scores and QOL scores in patients undergoing cancer therapy.

Original languageEnglish
Pages (from-to)485-494
Number of pages10
JournalAsian Pacific Journal of Cancer Prevention
Issue number2
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This study was supported by the Medical Research Center Program (No. 2011-0030074) through National Research Foundation (NRF) grant funded by the Korean government (MSIP). We would like to thank to Ji-In Yoon (Sookmyung Women’s University, Seoul, Republic of Korea) for providing technical assistance in manuscript preparation. This work is a part of the Master’s degree thesis for Eunbo Sim at Yonsei University.

Publisher Copyright:
© 2022, Asian Pacific Journal of Cancer Prevention. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research


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