The effect of platelet-enriched fibrin glue on bone regeneration in autogenous bone grafts

Jin Young Huh, Byung Ho Choi, Shi Jiang Zhu, Jae Hyung Jung, Byung Yong Kim, Seoung Ho Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective. The aim of this study was to examine the ability of platelet-enriched fibrin glue to enhance bone formation in critically sized defects in the dog mandible. Study design. Seven adult female mongrel dogs underwent continuity resections on both sides of the mandible; 1 defect was reconstructed with the original particulate bone mixed with platelet-enriched fibrin glue, and as a control the contralateral defect was reconstructed with the original particulate bone alone. Results. Biopsies after 6 weeks showed that the addition of platelet-enriched fibrin glue enhanced new bone formation in the autogenous bone grafts. Conclusion. Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in platelet-enriched fibrin glue, might effectively promote bone healing at bone graft sites.

Original languageEnglish
Pages (from-to)426-431
Number of pages6
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Volume101
Issue number4
DOIs
Publication statusPublished - 2006 Apr 1

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Fibrin Tissue Adhesive
Bone Regeneration
Blood Platelets
Transplants
Bone and Bones
Mandible
Osteogenesis
Dogs
Fibrin
Fibrinogen
Intercellular Signaling Peptides and Proteins
Biopsy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Huh, Jin Young ; Choi, Byung Ho ; Zhu, Shi Jiang ; Jung, Jae Hyung ; Kim, Byung Yong ; Lee, Seoung Ho. / The effect of platelet-enriched fibrin glue on bone regeneration in autogenous bone grafts. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2006 ; Vol. 101, No. 4. pp. 426-431.
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The effect of platelet-enriched fibrin glue on bone regeneration in autogenous bone grafts. / Huh, Jin Young; Choi, Byung Ho; Zhu, Shi Jiang; Jung, Jae Hyung; Kim, Byung Yong; Lee, Seoung Ho.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, Vol. 101, No. 4, 01.04.2006, p. 426-431.

Research output: Contribution to journalArticle

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AB - Objective. The aim of this study was to examine the ability of platelet-enriched fibrin glue to enhance bone formation in critically sized defects in the dog mandible. Study design. Seven adult female mongrel dogs underwent continuity resections on both sides of the mandible; 1 defect was reconstructed with the original particulate bone mixed with platelet-enriched fibrin glue, and as a control the contralateral defect was reconstructed with the original particulate bone alone. Results. Biopsies after 6 weeks showed that the addition of platelet-enriched fibrin glue enhanced new bone formation in the autogenous bone grafts. Conclusion. Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in platelet-enriched fibrin glue, might effectively promote bone healing at bone graft sites.

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