The effect of Rhus verniciflua stokes extracts on photo-Aged mouse skin

Hannah Hong, Minyoung Jung, Sung Jay Choe, Jung Bae Kim, Eung Ho Choi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Rhus verniciflua Stokes (RV) has traditionally been used in Korea as an indigenous food (Rhus chicken soup) and as an herbal medicinal plant. While the anticancer, antimicrobial, and anti-inflammatory properties of RV have been actively studied in the medical field, its antioxidant effects in the skin that resist the reactive oxygen species in keratinocytes and fibroblasts is less understood. Objective: We designed to evaluate the effects of R. verniciflua Stokes extract (RVE) on the photo-Aged skin by an in vitro experiment using human fibroblasts and an in vivo experiment using a photo-Aged murine model. Methods: For the in vitro experiments, human fibroblasts irradiated with ultraviolet (UV) B were treated with RVE or vehicle, and the growth levels and the expression level of type 1 procollagen were compared. For the in vivo experiment, photo-Aged mice irradiated with UVB and UVA were administered drinking water with or without RVE, and histological changes and the expression level of type 1 procollagen and matrix metalloprotease (MMP)-13 were compared. Results: In vitro experiments using fibroblasts irradiated with UVB showed that RVE promoted growth and significantly increased the expression of type 1 procollagen as compared to the control group. In the photo-Aged mice, RVE increased collagen content in the dermis and promoted the synthesis of type 1 procollagen without any visible decrease in MMP-13 as compared to control group. Conclusion: In addition to the previously reported antioxidant effects of RVE, oral intake of RVE effectively inhibited photo-Aging in hairless mice by enhancing collagen synthesis.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalAnnals of Dermatology
Volume29
Issue number3
DOIs
Publication statusPublished - 2017 Jun

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Rhus
Collagen Type I
Fibroblasts
Skin
Metalloproteases
Collagen
Antioxidants
Hairless Mouse
Control Groups
Dermis
Medicinal Plants
Korea
Growth
Keratinocytes
Drinking Water
Chickens
Reactive Oxygen Species
Anti-Inflammatory Agents
Food
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Hong, Hannah ; Jung, Minyoung ; Choe, Sung Jay ; Kim, Jung Bae ; Choi, Eung Ho. / The effect of Rhus verniciflua stokes extracts on photo-Aged mouse skin. In: Annals of Dermatology. 2017 ; Vol. 29, No. 3. pp. 295-301.
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abstract = "Background: Rhus verniciflua Stokes (RV) has traditionally been used in Korea as an indigenous food (Rhus chicken soup) and as an herbal medicinal plant. While the anticancer, antimicrobial, and anti-inflammatory properties of RV have been actively studied in the medical field, its antioxidant effects in the skin that resist the reactive oxygen species in keratinocytes and fibroblasts is less understood. Objective: We designed to evaluate the effects of R. verniciflua Stokes extract (RVE) on the photo-Aged skin by an in vitro experiment using human fibroblasts and an in vivo experiment using a photo-Aged murine model. Methods: For the in vitro experiments, human fibroblasts irradiated with ultraviolet (UV) B were treated with RVE or vehicle, and the growth levels and the expression level of type 1 procollagen were compared. For the in vivo experiment, photo-Aged mice irradiated with UVB and UVA were administered drinking water with or without RVE, and histological changes and the expression level of type 1 procollagen and matrix metalloprotease (MMP)-13 were compared. Results: In vitro experiments using fibroblasts irradiated with UVB showed that RVE promoted growth and significantly increased the expression of type 1 procollagen as compared to the control group. In the photo-Aged mice, RVE increased collagen content in the dermis and promoted the synthesis of type 1 procollagen without any visible decrease in MMP-13 as compared to control group. Conclusion: In addition to the previously reported antioxidant effects of RVE, oral intake of RVE effectively inhibited photo-Aging in hairless mice by enhancing collagen synthesis.",
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The effect of Rhus verniciflua stokes extracts on photo-Aged mouse skin. / Hong, Hannah; Jung, Minyoung; Choe, Sung Jay; Kim, Jung Bae; Choi, Eung Ho.

In: Annals of Dermatology, Vol. 29, No. 3, 06.2017, p. 295-301.

Research output: Contribution to journalArticle

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T1 - The effect of Rhus verniciflua stokes extracts on photo-Aged mouse skin

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AU - Jung, Minyoung

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N2 - Background: Rhus verniciflua Stokes (RV) has traditionally been used in Korea as an indigenous food (Rhus chicken soup) and as an herbal medicinal plant. While the anticancer, antimicrobial, and anti-inflammatory properties of RV have been actively studied in the medical field, its antioxidant effects in the skin that resist the reactive oxygen species in keratinocytes and fibroblasts is less understood. Objective: We designed to evaluate the effects of R. verniciflua Stokes extract (RVE) on the photo-Aged skin by an in vitro experiment using human fibroblasts and an in vivo experiment using a photo-Aged murine model. Methods: For the in vitro experiments, human fibroblasts irradiated with ultraviolet (UV) B were treated with RVE or vehicle, and the growth levels and the expression level of type 1 procollagen were compared. For the in vivo experiment, photo-Aged mice irradiated with UVB and UVA were administered drinking water with or without RVE, and histological changes and the expression level of type 1 procollagen and matrix metalloprotease (MMP)-13 were compared. Results: In vitro experiments using fibroblasts irradiated with UVB showed that RVE promoted growth and significantly increased the expression of type 1 procollagen as compared to the control group. In the photo-Aged mice, RVE increased collagen content in the dermis and promoted the synthesis of type 1 procollagen without any visible decrease in MMP-13 as compared to control group. Conclusion: In addition to the previously reported antioxidant effects of RVE, oral intake of RVE effectively inhibited photo-Aging in hairless mice by enhancing collagen synthesis.

AB - Background: Rhus verniciflua Stokes (RV) has traditionally been used in Korea as an indigenous food (Rhus chicken soup) and as an herbal medicinal plant. While the anticancer, antimicrobial, and anti-inflammatory properties of RV have been actively studied in the medical field, its antioxidant effects in the skin that resist the reactive oxygen species in keratinocytes and fibroblasts is less understood. Objective: We designed to evaluate the effects of R. verniciflua Stokes extract (RVE) on the photo-Aged skin by an in vitro experiment using human fibroblasts and an in vivo experiment using a photo-Aged murine model. Methods: For the in vitro experiments, human fibroblasts irradiated with ultraviolet (UV) B were treated with RVE or vehicle, and the growth levels and the expression level of type 1 procollagen were compared. For the in vivo experiment, photo-Aged mice irradiated with UVB and UVA were administered drinking water with or without RVE, and histological changes and the expression level of type 1 procollagen and matrix metalloprotease (MMP)-13 were compared. Results: In vitro experiments using fibroblasts irradiated with UVB showed that RVE promoted growth and significantly increased the expression of type 1 procollagen as compared to the control group. In the photo-Aged mice, RVE increased collagen content in the dermis and promoted the synthesis of type 1 procollagen without any visible decrease in MMP-13 as compared to control group. Conclusion: In addition to the previously reported antioxidant effects of RVE, oral intake of RVE effectively inhibited photo-Aging in hairless mice by enhancing collagen synthesis.

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