The effect of sodium alginate on physical and dissolution properties of Surelease®-matrix pellets prepared by a novel pelletizer

Min Soo Kim, Jeong Soo Kim, Sung Joo Hwang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of this study was to investigate the effect of sodium alginate on the physical and dissolution properties of Surelease®-matrix pellets prepared by a novel pelletizer-equipped piston extruder and double-arm counter-rotating rollers. The mean values of the shape factor (eR) and the aspect ratio of Surelease®-matrix pellets were 0.615-0.625 and 1.06-1.070, respectively, indicating good sphericity of the pellets. The drug release rate increased as the amount of sodium alginate increased due to hydration, swelling, and erosion within the Surelease®-matrix pellets. In addition, the porosity of pellets also increased with increasing sodium alginate content. The results of this study show that sodium alginate has a greater effect on the drug release rate than the drug release mechanism within the Surelease®-matrix for sparingly water-soluble drug, such as tamsulosin hydrochloride.

Original languageEnglish
Pages (from-to)1631-1634
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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