The effect of sodium alginate on physical and dissolution properties of Surelease®-matrix pellets prepared by a novel pelletizer

Min Soo Kim; Jeong Soo Kim; Sung Joo Hwang

doi:10.1248/cpb.55.1631

The effect of sodium alginate on physical and dissolution properties of Surelease®-matrix pellets prepared by a novel pelletizer

Min Soo Kim, Jeong Soo Kim, Sung Joo Hwang

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The aim of this study was to investigate the effect of sodium alginate on the physical and dissolution properties of Surelease®-matrix pellets prepared by a novel pelletizer-equipped piston extruder and double-arm counter-rotating rollers. The mean values of the shape factor (e_R) and the aspect ratio of Surelease®-matrix pellets were 0.615-0.625 and 1.06-1.070, respectively, indicating good sphericity of the pellets. The drug release rate increased as the amount of sodium alginate increased due to hydration, swelling, and erosion within the Surelease®-matrix pellets. In addition, the porosity of pellets also increased with increasing sodium alginate content. The results of this study show that sodium alginate has a greater effect on the drug release rate than the drug release mechanism within the Surelease®-matrix for sparingly water-soluble drug, such as tamsulosin hydrochloride.

Original language	English
Pages (from-to)	1631-1634
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	55
Issue number	11
DOIs	https://doi.org/10.1248/cpb.55.1631
Publication status	Published - 2007 Nov

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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title = "The effect of sodium alginate on physical and dissolution properties of Surelease{\textregistered}-matrix pellets prepared by a novel pelletizer",

abstract = "The aim of this study was to investigate the effect of sodium alginate on the physical and dissolution properties of Surelease{\textregistered}-matrix pellets prepared by a novel pelletizer-equipped piston extruder and double-arm counter-rotating rollers. The mean values of the shape factor (eR) and the aspect ratio of Surelease{\textregistered}-matrix pellets were 0.615-0.625 and 1.06-1.070, respectively, indicating good sphericity of the pellets. The drug release rate increased as the amount of sodium alginate increased due to hydration, swelling, and erosion within the Surelease{\textregistered}-matrix pellets. In addition, the porosity of pellets also increased with increasing sodium alginate content. The results of this study show that sodium alginate has a greater effect on the drug release rate than the drug release mechanism within the Surelease{\textregistered}-matrix for sparingly water-soluble drug, such as tamsulosin hydrochloride.",

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The effect of sodium alginate on physical and dissolution properties of Surelease®-matrix pellets prepared by a novel pelletizer

Abstract

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